Results 231 to 240 of about 92,881 (268)

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

"Surviving and Thriving": evidence for cortical GABA stabilization in cognitively-intact oldest-old adults. [PDF]

Transl Psychiatry
Britton MK, Jensen G, Edden RA, Puts NA, Nolin SA, Merritt SS, Rezaei RF, Forbes M, Johnson KJ, Bharadwaj PK, Franchetti MK, Raichlen DA, Jessup CJ, Hishaw GA, Van Etten EJ, Gudmundson AT, Murali-Manohar S, Cowart H, Trouard TP, Geldmacher DS, Wadley VG, Alperin N, Levin BE, Rundek T, Visscher KM, Woods AJ, Alexander GE, Cohen RA, Porges EC.   +28 more
europepmc   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Correction: Factors associated with pressure ulcers among middle-old and oldest-old inpatients in an acute care hospital. [PDF]

Sci Rep
Itoh S, Yokota S, Yotsu RR, Tanaka S, Abe K, Kodama K, Nakagawa R, Nabetani Y, Kobayashi K, Murata T, Takeda T, Matsumura Y, Kikuchi M.   +12 more
europepmc   +1 more source

Impact of Asymptomatic Intracranial Hemorrhage on Outcome After Endovascular Stroke Treatment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Endovascular treatment (EVT) achieves high rates of recanalization in acute large‐vessel occlusion (LVO) stroke, but functional recovery remains heterogeneous. While symptomatic intracranial hemorrhage (sICH) has been well studied, the prognostic impact of asymptomatic intracranial hemorrhage (aICH) after EVT is less certain ...
Shihai Yang, Chengsong Yue, Zhuang Li, Xiaolei Shi, Haoxuan Zhu, Jie Yang, Linyu Li, Jiaxing Song, Shitao Fan, Gaoming Li, Wenzhe Sun, Zhixian Ye, Jiacheng Huang, Dahong Yang, Jinfu Ma, Xu Xu, Zhixi Wang, Lilan Wang, Guojian Liu, Fengli Li, Changwei Guo, Li Qi, Wenjie Zi   +22 more
wiley   +1 more source

Brain amyloid-β deposition, severity of subjective cognitive decline and gait speed in cognitively unimpaired oldest-old. [PDF]

J Alzheimers Dis
Nadkarni NK, Perera S, Snitz BE, Lopresti BJ, Gogniat MA, Villemagne VL, Lopez OL.   +6 more
europepmc   +1 more source

The impact of physical and mind exercise on functional disability in activities of daily living among the oldest old. [PDF]

BMC Public Health
Wang S, Wu Z, Guo Z, Wang F, Liu B.
europepmc   +1 more source

Management and Outcomes of Pulmonary Embolism in the Oldest-Old. [PDF]

Int J Gen Med
Beotra E, Ngian VJJ, Tran F, Hsu K, O'Rourke F, Ong BS.   +5 more
europepmc   +1 more source