Results 241 to 250 of about 735,066 (303)

Advancing care: optimizing osteoporosis treatment in the older and oldest old population. [PDF]

Aging Clin Exp Res
Panait C, D'Amelio P.
europepmc   +1 more source

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Network segregation is associated with processing speed in the cognitively healthy oldest-old. [PDF]

Elife
Nolin SA, Faulkner ME, Stewart P, Fleming LL, Merritt S, Rezaei RF, Bharadwaj PK, Franchetti MK, Raichlen DA, Jessup CJ, Edwards L, Hishaw GA, Van Etten EJ, Trouard TP, Geldmacher D, Wadley VG, Alperin N, Porges ES, Woods AJ, Cohen RA, Levin BE, Rundek T, Alexander GE, Visscher KM.   +23 more
europepmc   +1 more source

Evidence of Iron Accumulation in Cerebral Adrenoleukodystrophy: A Potential Novel Disease Mechanism

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT In this first application of Quantitative Susceptibility Mapping Source Separation to cerebral adrenoleukodystrophy, we uncovered alterations in iron and myelin within lesions and normal appearing white matter. As validation, we demonstrate abnormal iron accumulation in those same compartments within primary brain tissue.
Christina L. Nemeth, Mert Sisman, Jinwei Zhang, Hyeong‐geol Shin, Xu Li, Bela Turk, Ali Fatemi, Thanh Nguyen, Eric Mallack   +8 more
wiley   +1 more source

Establishment of Reference Intervals for Serum Thyroid-related Hormones in the Chinese Oldest-old. [PDF]

Int J Med Sci
Liu D, Fang S, Gao D, Wang Z, Wang T, Tang L, Jiang M, Jiao J, Zhao H, Su H, Li R, Huang B, Lv Y, Pang G, Hu C, Yang Z, Yuan H.   +16 more
europepmc   +1 more source

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai   +11 more
wiley   +1 more source

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source

"Surviving and Thriving": evidence for cortical GABA stabilization in cognitively-intact oldest-old adults. [PDF]

Transl Psychiatry
Britton MK, Jensen G, Edden RA, Puts NA, Nolin SA, Merritt SS, Rezaei RF, Forbes M, Johnson KJ, Bharadwaj PK, Franchetti MK, Raichlen DA, Jessup CJ, Hishaw GA, Van Etten EJ, Gudmundson AT, Murali-Manohar S, Cowart H, Trouard TP, Geldmacher DS, Wadley VG, Alperin N, Levin BE, Rundek T, Visscher KM, Woods AJ, Alexander GE, Cohen RA, Porges EC.   +28 more
europepmc   +1 more source

Correction: Factors associated with pressure ulcers among middle-old and oldest-old inpatients in an acute care hospital. [PDF]

Sci Rep
Itoh S, Yokota S, Yotsu RR, Tanaka S, Abe K, Kodama K, Nakagawa R, Nabetani Y, Kobayashi K, Murata T, Takeda T, Matsumura Y, Kikuchi M.   +12 more
europepmc   +1 more source