Results 261 to 270 of about 149,007 (299)

Allelic inactivation regulates olfactory receptor gene expression

Cell, 1994
We suggest a model in which a hierarchy of controls is exerted on the family of odorant receptor genes to assure that a sensory neuron expresses a single receptor from a family of 1000 genes. We propose that a cis-regulatory element directs the stochastic expression of only one gene from a large array of linked receptor genes.
Itamar Simon, Howard Cedar, Richard Axel
exaly   +3 more sources

Olfactory receptor gene expression

Seminars in Cell & Developmental Biology, 1997
Recognition and discrimination of odorous molecules are determined by heptahelical G-protein-coupled receptor proteins localized primarily in the ciliary membrane of olfactory sensory neurons. The discovery of a large multigene family encoding odorant receptors allows us to approach various facets concerning the molecular basis of olfactory ...
H, Breer, J, Strotmann
openaire   +2 more sources

Olfactory receptor gene expression in tiger salamander olfactory epithelium

Journal of Comparative Neurology, 2004
AbstractPhysiological studies of odor‐elicited responses from the olfactory epithelium and bulb in the tiger salamander, Ambystoma tigrinum, have elucidated a number of features of olfactory coding that appear to be conserved across several vertebrate species.
James E, Marchand, Xinhai, Yang, Dona, Chikaraishi, Jurgen, Krieger, Heinz, Breer, John S, Kauer   +5 more
openaire   +2 more sources

Olfactory receptor gene repertoires in mammals

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2007
In mammals, olfaction is mediated by two distinct organs that are located in the nasal cavity: the main olfactory epithelium (MOE) that binds volatile odorants is responsible for the conscious perception of odors, and the vomeronasal organ (VNO) that binds pheromones is responsible for various behavioral and neuroendocrine responses between individuals
Rouquier, Sylvie, Giorgi, D.
openaire   +2 more sources

Comparative gene expression profiling of olfactory ensheathing cells from olfactory bulb and olfactory mucosa

Glia, 2010
AbstractOlfactory ensheathing cells (OEC) have the ability to promote regeneration in the nervous system. Hence, they hold promise for cell therapy. Most of the experimental studies have investigated the role of OECs taken from olfactory bulb (OB). However, for a clinical human application, olfactory mucosa (OM) seems to be the only acceptable source ...
Guérout, Nicolas, Derambure, Céline, Drouot, Laurent, Bon-Mardion, Nicolas, Duclos, Célia, Boyer, Olivier, Marie, Jean-Paul   +6 more
openaire   +3 more sources

OS9: A novel olfactory gene of Drosophila expressed in two olfactory organs

Journal of Neurobiology, 1994
AbstractA novel olfactory gene, OS9, has been identified in Drosophila by subtractive hybridization. OS9 transcripts have been detected in the third antennal segment, the primary olfactory organ in Drosophila, and in the maxillary palp, which has recently been shown to have olfactory function.
D, Raha, J, Carlson
openaire   +2 more sources

Olfactory Receptor Gene Regulation

1998
The mammalian olfactory system recognizes and discriminates a vast array of odorant ligands . The number of odors that can be distinguished is on the order of tens of thousands. Recognition is accomplished, initially, by members of a family of 1000 odorant receptors. Thus the olfactory system rivals the immune system in its ability to recognize a large
openaire   +2 more sources

The olfactory receptor gene superfamily of the mouse

Nature Neuroscience, 2002
Olfactory receptor (OR) genes are the largest gene superfamily in vertebrates. We have identified the mouse OR genes from the nearly complete Celera mouse genome by a comprehensive data mining strategy. We found 1,296 mouse OR genes (including 20% pseudogenes), which can be classified into 228 families.
Xinmin, Zhang, Stuart, Firestein
openaire   +2 more sources

Polymorphisms in olfactory receptor genes: a cautionary note

Human Immunology, 2000
The hundreds of human olfactory receptor (OR) genes are organized into clusters occurring on nearly every chromosome. Although their sequences are not always closely related, they share stretches of considerable similarity, both at the amino acid and nucleotide levels.
A, Ziegler, A, Ehlers, S, Forbes, J, Trowsdale, A, Volz, R, Younger, S, Beck   +6 more
openaire   +2 more sources

Adenovirus-mediated gene transfer in olfactory neuronsin vivo

Journal of Neurobiology, 1996
We used recombinant adenoviruses as a means of expressing exogenous genes in olfactory neurons in vivo. A replication incompetent adenovirus (type 5, Ad5) carrying the reporter gene lacZ, which codes for the enzyme beta-galactosidase (beta-Gal), was applied in solution to the olfactory epithelia of rats.
H, Zhao, J M, Otaki, S, Firestein
openaire   +2 more sources