Results 61 to 70 of about 479,175 (294)

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Olfactory nerve--a novel invasion route of Neisseria meningitidis to reach the meninges. [PDF]

PLoS ONE, 2010
Neisseria meningitidis is a human-specific pathogen with capacity to cause septic shock and meningitis. It has been hypothesized that invasion of the central nervous system (CNS) is a complication of a bacteremic condition.
Hong Sjölinder, Ann-Beth Jonsson
doaj   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Phagocytosis by Peripheral Glia: Importance for Nervous System Functions and Implications in Injury and Disease

Frontiers in Cell and Developmental Biology, 2021
The central nervous system (CNS) has very limited capacity to regenerate after traumatic injury or disease. In contrast, the peripheral nervous system (PNS) has far greater capacity for regeneration.
Lynn Nazareth, Lynn Nazareth, James St John, James St John, James St John, Mariyam Murtaza, Mariyam Murtaza, Mariyam Murtaza, Jenny Ekberg, Jenny Ekberg, Jenny Ekberg   +10 more
doaj   +1 more source

Histological markers in nasal mucosa of patients with Alzheimer's disease [PDF]

, 1998
Neuropathological changes such as dystrophic neurites and the presence of abnormal tau protein in the olfactory system, including primary sensory cells and nerve fibres have previously been demonstrated in nasal mucosa tissue of patients with Alzheimer's
Müller-Spahn, Franz, Mandelkow, Eva-Maria, Golombowski, Sidonie, Peschel, Oliver, Unger, Jürgen, Hock, Christoph, Probst, Alphonse, Riederer, Andreas, Unger J, Peschel O, Golombowski S, Müller-Spahn F, Mandelkow E, Hock C, Riederer A, Probst A   +15 more
core   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Axon fasciculation in the developing olfactory nerve [PDF]

Neural Development, 2010
AbstractOlfactory sensory neuron (OSN) axons exit the olfactory epithelium (OE) and extend toward the olfactory bulb (OB) where they coalesce into glomeruli. Each OSN expresses only 1 of approximately 1,200 odor receptors (ORs). OSNs expressing the same OR are distributed in restricted zones of the OE.
Miller Alexandra M, Maurer Lydia R, Zou Dong-Jing, Firestein Stuart, Greer Charles A   +4 more
openaire   +3 more sources

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

Primary Olfactory Ensheathing Cell Culture from Human Olfactory Mucosa Specimen

Bio-Protocol, 2017
The human olfactory mucosa is located in the middle and superior turbinates, and the septum of nasal cavity. Olfactory mucosa plays an important role in detection of odours and it is also the only nervous tissue that is exposed to the external ...
Mansoureh Hashemi, Mahmoudreza Hadjighassem   +1 more
doaj   +1 more source

Intercellular interactions in the mammalian olfactory nerve [PDF]

Journal of Comparative Neurology, 2003
AbstractThe small, unmyelinated axons of olfactory sensory neurons project to the olfactory bulb in densely packed fascicles, an arrangement conducive to axo‐axonal interactions. We recently demonstrated ephaptic interactions between these axons in the olfactory nerve layer, the layer of the olfactory bulb in which the axon fascicles interweave and ...
Karen J, Blinder, David W, Pumplin, D L, Paul, Asaf, Keller   +3 more
openaire   +2 more sources