Results 61 to 70 of about 7,995 (197)

Supplementary Data from Comprehensive Molecular Profiling of Olfactory Neuroblastoma Identifies Potentially Targetable FGFR3 Amplifications

, 2017
Figure S1. (A) Overexpression of p53 in olfactory neuroblastoma tumor harboring an inactivating TP53 mutation. (B) Representative example of p53 expression in olfactory neuroblastoma tumor lacking TP53 mutation.
Jonathan B. McHugh (9582084), Lorena Lazo de la Vega (15007548), Paul W. Harms (14925723), Dan Robinson (228751), Komal Kunder (15077037), Chia-Jen Liu (328474), Frances M. Walocko (15077040), Arul M. Chinnaiyan (59535), Daniel H. Hovelson (14919882), Andi K. Cani (14919885), Scott A. Tomlins (14875139)   +10 more
core   +1 more source

Frontal Sinus “Hump”: An Anatomical Risk Factor for Anterior Skull Base Injury in the Endoscopic Modified Lothrop Approach (Outside-In Frontal Drill-Out)

Case Reports in Otolaryngology, 2021
Skull base injuries caused by the outside-in frontal drill-out technique have not been reported. In this report, we chose an outside-in approach to open the frontal sinus for olfactory neuroblastoma resection.
Teppei Takeda, Kazuhiro Omura, Haw Torng, Teru Ebihara, Satoshi Aoki, Kosuke Tochigi, Hiromi Kojima, Nobuyoshi Otori   +7 more
doaj   +1 more source

Drafting the calmodulation playbook: Emerging structural insights into transient receptor potential channel regulation by calmodulin

The Journal of Physiology, EarlyView.
Abstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Aden M. Alemayhu, Candice E. Paulsen
wiley   +1 more source

The genomics and epigenetics of olfactory neuroblastoma: A systematic review

Laryngoscope Investigative Otolaryngology, 2021
Background Olfactory neuroblastoma (ONB) or esthesioneuroblastoma (ENB) is a rare malignancy of the nasal cavity believed to arise from the olfactory epithelium.
Raman Preet Kaur, Evgeny Izumchenko, Dukagjin M. Blakaj, Nikol Mladkova, Matt Lechner, Thomas L. Beaumont, Charalampos S. Floudas, Gary L. Gallia, Nyall R. London Jr   +8 more
doaj   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Bilateral Synchronous Ectopic Ethmoid Sinus Olfactory Neuroblastoma: A Case Report.

, 2016
Olfactory neuroblastoma (ONB), also known as esthesioneuroblastoma, is a rare malignant head and neck cancer thought to originate from the olfactory epithelium. It typically invades contiguous structures at presentation.
Alfonso, Carolina, Lassaletta, Luis, Yebenes, Laura, Garcia-Polo, Julio, Leon-Soriano, Elena, Gavilan, Javier   +5 more
core   +1 more source

The role of chemotherapy in the management of olfactory neuroblastoma: A 40‐year surveillance, epidemiology, and end results registry study

Health Science Reports, 2021
Background In this retrospective surveillance, epidemiology, and end results (SEER) registry analysis, we investigated the role of chemotherapy (CT) in the treatment of olfactory neuroblastoma (ON), an exceedingly rare sino‐nasal tumor typically treated ...
Ryan J. Brisson, Thomas J. Quinn, Rohan L. Deraniyagala   +2 more
doaj   +1 more source

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, Volume 15, Issue 21, 5 June 2026.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

Endonasal Endoscopic Resection and Radiotherapy in Olfactory Neuroblastoma: our experience. [PDF]

, 2007
Background. Our aim was to evaluate the efficacy of a bimodal method of treatment consisting in endoscopic resection followed by radiotherapy in patients with olfactory neuroblastoma (ON). Methods.
BIGNAMI, MAURIZIO, BATTAGLIA, PAOLO, IACOPO DALLAN, MARIO BIGNARDI, CASTELNUOVO, PAOLO GIOCONDO MARIA, GIOVANNI DEL   +5 more
core   +1 more source

Olfactory neuroblastoma: a pathological study

, 1976
Six cases of olfactory neuroblastoma are studied and a review of the literature on this subject is attempted. Four of these neoplasms are found among a total of 239 tumours of the masal fossae (1,6%).
Kyroudes-Voulgaris, Aspasia, Κυρούδη-Βούλγαρη, Ασπασία   +1 more
core   +1 more source