Results 31 to 40 of about 111,965 (263)

Amygdala Neurodegeneration: A Key Driver of Visual Dysfunction in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Visual disability in Parkinson's disease (PD) is not fully explained by retinal neurodegeneration. We aimed to delineate the brain substrate of visual dysfunction in PD and its association with retinal thickness. Methods Forty‐two PD patients and 29 controls underwent 3‐Tesla MRI, retinal spectral‐domain optical coherence tomography,
Asier Erramuzpe, Ane Murueta‐Goyena, Antonio Jimenez‐Marin, Marian Acera, Sara Teijeira‐Portas, Rocío Del Pino, Tamara Fernández‐Valle, Ibai Diez, Unai Sainz‐Lugarezaresti, Naroa Ibarretxe‐Bilbao, Unai Ayala, Maitane Barrenechea, Alberto Cabrera‐Zubizarreta, Jesús Cortés, Juan Carlos Gómez‐Esteban, Iñigo Gabilondo   +15 more
wiley   +1 more source

Neuropeptide complexity in the crustacean central olfactory pathway: immunolocalization of A-type allatostatins and RFamide-like peptides in the brain of a terrestrial hermit crab

Molecular Brain, 2012
Background In the olfactory system of malacostracan crustaceans, axonal input from olfactory receptor neurons associated with aesthetascs on the animal’s first pair of antennae target primary processing centers in the median brain, the olfactory lobes ...
Polanska Marta A, Tuchina Oksana, Agricola Hans, Hansson Bill S, Harzsch Steffen   +4 more
doaj   +1 more source

Clinical Phenotyping of Long COVID Patients Evaluated in a Specialized Neuro‐COVID Clinic

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To report Long COVID characteristics and longitudinal courses of patients evaluated between 4/14/21–4/14/22 at the University of Pennsylvania Neurological COVID Clinic (PNCC), including clinical symptoms, neurological examination findings, and neurocognitive screening tests from a standardized PNCC neurological evaluation approach ...
Luana D. Yamashita, Neel Desai, Abigail R. Manning, Caitlin Pileggi, Sara Manning Peskin, Danielle K. Sandsmark, Dennis L. Kolson, Matthew K. Schindler   +7 more
wiley   +1 more source

Olfactory Evaluation in Alzheimer’s Disease Model Mice

Brain Sciences, 2022
Olfactory dysfunction is considered a pre-cognitive biomarker of Alzheimer’s disease (AD). Because the olfactory system is highly conserved across species, mouse models corresponding to various AD etiologies have been bred and used in numerous studies on
Jingjing Zhang, Zixuan Zhao, Siqi Sun, Jing Li, Yu Wang, Jingyin Dong, Su Yang, Yiyi Lou, Jing Yang, Weiyun Li, Shanshan Li   +10 more
doaj   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Development of a noninvasive olfactory stimulation fMRI system in marmosets

Scientific Reports
Olfactory dysfunction is associated with aging and the earliest stages of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases; it is thought to be an early biomarker of cognitive decline. In marmosets, a small non-human primate model
Terumi Yurimoto, Fumiko Seki, Akihiro Yamada, Junnosuke Okajima, Tomoyuki Yambe, Yoshiaki Takewa, Michiko Kamioka, Takashi Inoue, Yusuke Inoue, Erika Sasaki   +9 more
doaj   +1 more source

Circuit dynamics of the olfactory pathway during olfactory learning

Frontiers in Neural Circuits
The olfactory system plays crucial roles in perceiving and interacting with their surroundings. Previous studies have deciphered basic odor perceptions, but how information processing in the olfactory system is associated with learning and memory is ...
Yutian J. Zhang, Jason Y. Lee, Kei M. Igarashi, Kei M. Igarashi, Kei M. Igarashi, Kei M. Igarashi, Kei M. Igarashi   +6 more
doaj   +1 more source

Characterizing functional pathways of the human olfactory system

eLife, 2019
The central processing pathways of the human olfactory system are not fully understood. The olfactory bulb projects directly to a number of cortical brain structures, but the distinct networks formed by projections from each of these structures to the ...
Guangyu Zhou, Gregory Lane, Shiloh L Cooper, Thorsten Kahnt, Christina Zelano   +4 more
doaj   +1 more source

Nasal Administration of Cholera Toxin as a Mucosal Adjuvant Damages the Olfactory System in Mice. [PDF]

PLoS ONE, 2015
Cholera toxin (CT) induces severe diarrhea in humans but acts as an adjuvant to enhance immune responses to vaccines when administered orally. Nasally administered CT also acts as an adjuvant, but CT and CT derivatives, including the B subunit of CT (CTB)
Yoshiko Fukuyama, Kazunari Okada, Masahiro Yamaguchi, Hiroshi Kiyono, Kensaku Mori, Yoshikazu Yuki   +5 more
doaj   +1 more source

Bioresorbable and Wireless Rechargeable Implanted Na‐ion Battery for Temporary Medical Devices

Advanced Functional Materials, EarlyView.
An all‐solid‐state bioresorbable Na‐ion battery is developed, composed entirely of bio‐eliminable materials. In vivo and ex vivo tests confirmed harmless disintegration of this implanted battery. Lifetime of the implanted battery can be precisely controlled by adjusting the dissolvable encapsulation layer's thickness.
Vedi Kuyil Azhagan Muniraj, Bincy Lathakumary Vijayan, Hussien Hammoud, Roger Delattre, Marc Ramuz, Eve Djenizian, Eleonora Vandini, Daniela Giuliani, Thierry Djenizian   +8 more
wiley   +1 more source