Results 81 to 90 of about 51,216 (167)
Pharmacogenetics of follicle‐stimulating hormone action in the male
Andrology, EarlyView.Abstract Male factor infertility (MFI) is involved in half of the cases of couple infertility. The follicle‐stimulating hormone (FSH) therapy is considered efficient to improve semen parameters and pregnancy rate in patients with idiopathic MFI, following the lesson learned from hypogonadotropic hypogonadism.
Andrea Graziani +7 more
wiley +1 more source
Untangling nutrient co‐regulation of ombrotrophic peatland development
Boreas, EarlyView.Multi‐method (FTIR, FT‐NIR and TGA) approaches characterizing the organic peat constituents at Holcroft Moss reveal a record of switches that reflect broadly hydroclimate variability governing the decomposition patterns. There are periods, however, where hydroclimate does not fully explain the variability observed and instead changes appear linked to ...
Richard C. Chiverrell +6 more
wiley +1 more source
Cell Proliferation, EarlyView.Maternal TCF12 ensures the competence of fertilisation by controlling the expression of Astl and the proper location of cortical granules. Furthermore, maternal TCF12 maintains the phosphatase activity of PP2A by regulating the expression of Arpp19. Oocyte‐specific deletion of Tcf12 leads to fertilisation defects as well as ZGA failure at the 2‐cell ...
Lan‐Rui Cao +7 more
wiley +1 more source
Transcriptional regulation of human NMNAT2: insights from 3D genome sequencing and bioinformatics
The FEBS Journal, EarlyView.NMNAT2 is a valuable drug target, as low levels increase the risk of neurodegeneration. We employed 4C‐seq to identify NMNAT2 regulatory regions in the human genome, revealing distinct interactomes of the NMNAT2 promoter in undifferentiated and neuron‐like SH‐SY5Y cells. Additionally, we uncovered NMNAT2‐associated genes and transcription factors. This
Yu Chen Chang +5 more
wiley +1 more source
SARS‐CoV‐2 nucleocapsid protein variants have differential RNA chaperone activity
The FEBS Journal, EarlyView.The SARS‐CoV‐2 nucleocapsid (N) protein facilitates RNA annealing through its RBD–IDR2–CTD region, identifying it as a functional RNA chaperone. The Omicron BA.5 variant shows reduced chaperone activity compared to the Wuhan wild‐type protein. Although phosphorylation has no effect on wild‐type N, phosphomimetic modification of BA.5 N restores its RNA ...
Sabrina Babl +11 more
wiley +1 more source
Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1
The FEBS Journal, EarlyView.PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio +12 more
wiley +1 more source
Review of expansion microscopy combined with advanced imaging modalities
Journal of Microscopy, EarlyView.Abstract Expansion microscopy (ExM) is a powerful high‐resolution imaging technique that enhances the spatial resolution of conventional light microscopy by physically enlarging biological specimens by embedding and cross‐linking them in a swellable polymer network.
Natalie Woo, Claire M. Brown
wiley +1 more source
EBSn, a Robust Synthetic Reporter for Monitoring Ethylene Responses in Plants
Plant Biotechnology Journal, EarlyView.ABSTRACT Ethylene is a gaseous plant hormone that controls a wide array of physiologically relevant processes, including plant responses to biotic and abiotic stress, and induces ripening in climacteric fruits. To monitor ethylene in plants, analytical methods, phenotypic assays, gene expression analysis and transcriptional or translational reporters ...
Josefina‐Patricia Fernandez‐Moreno +17 more
wiley +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT Bacterial blight (BB) of rice, caused by Xanthomonas oryzae pv. oryzae (Xoo), is one of the major drivers of yield losses in Africa and Asia. Xoo secretes TAL‐effectors (TALe) that induce host SWEET sucrose uniporter by binding to the effector binding element (EBE) of SWEET promoters, likely required for Xoo reproduction and virulence.
Eliza P. I. Loo +18 more
wiley +1 more source
OsSTK‐Mediated Sakuranetin Biosynthesis and Carbon Flux Orchestrate Growth and Defence in Rice
Plant Biotechnology Journal, EarlyView.ABSTRACT Plants balance resource energy allocation between growth and immunity to ensure survival and reproduction under limited availability. This study reveals that rice cultivars with elevated sucrose levels boost resistance to the fungal pathogen Magnaporthe oryzae by accumulating the phytoalexin sakuranetin, regulated by the transcription factor ...
Jitao Hu +14 more
wiley +1 more source