Results 141 to 150 of about 25,062 (219)

EGFR: New Insights on Its Activation and Mutation in Tumor and Tumor Immunotherapy

Advanced Science, EarlyView.
This review provides new perspectives on EGFR's activation, mutations, and their impact on tumor immunotherapy. It summarizes how EGFR is activated and the current EGFR targeting strategy, evaluates their clinical outcomes in combination with immunotherapy, highlighting differential responses in tumors with EGFR wild‐type and different mutants.
Yuanzhuo Gu, Hongchao He, Shilei Qiao, Yifan Shao, Lurong Wang, Zhengkui Zhang, Long Zhang, Fangfang Zhou   +7 more
wiley   +1 more source

End-to-End Backbone Cyclization Enhances Passive Permeability of bRo5 Oligomeric Depsipeptides with Nonlinear Size Dependence. [PDF]

ACS Med Chem Lett
Thorpe MP, Hopkins CR, Johnston JN.
europepmc   +1 more source

Structurally Constrained Cyclic (Diacyloxyiodo)Arenes as an Enabling Platform for Hypervalent Iodine(III) Chemistry

Advanced Science, EarlyView.
We developed cyclic (diacyloxyiodo)arenes to overcome the reactivity/selectivity paradox in iodine chemistry. This new platform enables simple, one‐pot synthesis of diverse hypervalent iodine(III) reagents. The method is sustainable, catalytic, works for asymmetric reactions, and is biocompatible (e.g., modifying peptides).
Shengyu Zhong, Shaoyan Gan, Xin Zhang, Lijuan Song, Lei Shi   +4 more
wiley   +1 more source

A novel hybrid approach to overcome defects of CE-SELEX and cell-SELEX in developing aptamers against aspartate β-hydroxylase. [PDF]

Res Pharm Sci
Bakhtiari H, Naghoosi H, Sattari S, Vahidi M, Khomartash MS, Faridfar A, Rajaeinejad M, Nikandish M.   +7 more
europepmc   +1 more source

Synthesis of Poly(1,4‐anthraquinone) Using Catalytic Amounts of Nickel

Advanced Science, EarlyView.
P14AQ is an excellent battery electrode material, especially for multivalent battery cells. A new synthetic route is presented using stable and easy‐to‐handle dibromobis(triphenylphosphine)nickel(II) (NiBr2(PPh3)2) in catalytic amounts instead of stoichiometric amounts of air‐ and temperature‐sensitive bis(cyclooct‐1,5‐diene)nickel(0) (Ni(COD)2).
Florin Adler, Sebastián Pinto‐Bautista, Christoph Lorenz, Lars Hinrichs, Marcel Weil, Birgit Esser   +5 more
wiley   +1 more source

Isoaspartate formation and irreversible aggregation of collapsin response mediator protein 2: implications for the etiology of epilepsy and age-related cognitive decline. [PDF]

Amino Acids
Zhu JX, Aswad DW.
europepmc   +1 more source

Volumetric Engineered 3D Drug Reservoir Against Diabetic Implant Infection via Cuproptosis‐Like Bacterial Death and Hunger‐Triggered Maintenance of Mitochondrial Integrity

Advanced Science, EarlyView.
This study provides a volumetric engineered 3D drug reservoir to combat diabetic implant infection. Cu‐doped quantum dots induce cuproptosis‐like bacterial death via metabolic collapse, while glucose oxidase triggers hunger‐triggered mitochondrial protection in host cells.
Dize Li, Hongrui Qin, Min Jiang, Hongjiang Wei, Hongyong Zhao, Ping Tang, Guangyu Jian, Henny C van der Mei, Tao Chen   +8 more
wiley   +1 more source

Formation of multiple G-quadruplexes contributes toward BCR fragility associated with chronic myelogenous leukemia. [PDF]

Nucleic Acids Res
Sharma S, Thomas E, Dahal S, Das S, Kothari S, Roy U, Kumari N, Gopalakrishnan V, Raghavan SC.   +8 more
europepmc   +1 more source

Topological Vulcanization Strategy for Elastomeric Electrolytes with Enhanced Mechanical and Electrochemical Properties for Advanced Lithium Metal Batteries

Advanced Science, EarlyView.
Elastomeric electrolytes (EEs) have garnered significant attention in the realm of energy storage system, attributed to their distinctive mechanical properties. In this study, we propose an innovative topological vulcanization stategy to fabricate uniformly crosslinked EEs.
Na Yang, Haotian Meng, DeCai Guo, Yongyi Song, Yongzheng Shi, Jin Niu, Feng Wang   +6 more
wiley   +1 more source

Investigation of Fibrillar Aggregates Formed by Pathogenic Pre-pro-vasopressin Mutants that Cause ADNDI.

J Clin Endocrinol Metab
Vaizoglu RD, Erdem B, Gul M, Acar C, Ozdemirel HO, Saglar Ozer E, Mergen H.   +6 more
europepmc   +1 more source