Results 71 to 80 of about 26,087 (219)

Multivalent Protein Nanorings for Broad and Potent SARS‐CoV‐2 Neutralization

Advanced Healthcare Materials, EarlyView.
A protein‐only, modular multivalent nanoscaffold displaying 20 anchor points, decorated with two different binders (10 of each), targeting the SARS‐CoV‐2 receptor‐binding domain is presented. The construct self‐assembles into stable, biocompatible, homogeneous nanoparticles, exhibit synergistic binding with fM IC50 values. It also detects spike at 9 ng 
Molood Behbahanipour, Carla Goldin, Cecilia Arahi Prato, Ana Luz Paletta, Oriol Bárcenas, Susanna Navarro, Jordi Pujols, Daniel H. Murgida, María Virginia Tribulatti, Sebastián Esperante, Damian Alvarez‐Paggi, Salvador Ventura   +11 more
wiley   +1 more source

siRNA Delivery via Cross‐Linked Gelatin Microparticles Enables Targeted Modulation of Osteogenic‐Vascular Cross‐Talk: An Advanced Human 3D in Vitro Test System for Therapeutic siRNA

Advanced Healthcare Materials, EarlyView.
Osteogenic‐angiogenic cross‐talk is a vital prerequisite for vascularized bone regeneration. In this study, we investigated the effects of siRNA‐mediated silencing of two inhibitory proteins, Chordin and WWP‐1, via CaP‐NP‐loaded gelatin microparticles in osteogenically differentiated microtissues.
Franziska Mitrach, Jonas Kubat, Stefan Simm, Alexandra H. Springwald, Burak Demir, Anton Liebezeit, Michael C. Hacker, Michaela Schulz‐Siegmund   +7 more
wiley   +1 more source

The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands. [PDF]

, 1997
One hypothesis seeking to explain the signaling and biological properties of T cell receptor for antigen (TCR) partial agonists and antagonists is the coreceptor density/kinetic model, which proposes that the pharmacologic behavior of a TCR ligand is ...
Bluestone, JA, Chau, LA, Germain, RN, Madrenas, J, Smith, J   +4 more
core  

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

Sculpting the Future of Bone: The Evolution of Absorbable Materials in Orthopedics

Advanced Materials, EarlyView.
This review summarizes the current status of polymeric, ceramic, and metallic absorbable materials in orthopedic applications, and highlights several innovative strategies designed to enhance mechanical performance, control degradation, and promote bioactivity. We also discuss the progress and translational potential of absorbable materials in treating
Zhao Wang, Zehui Lv, Xuejie Cai, Yingjie Wang, Bo Peng, Haojing Xu, Hualuo Pang, Xingdong Yang, Jiawei Xu, Yixin Bian, Bin Feng, Peng Wen, Yufeng Zheng, Xisheng Weng   +13 more
wiley   +1 more source

Azaporphyrinoid‐Based Photo‐ and Electroactive Architectures for Advanced Functional Materials

Advanced Materials, EarlyView.
A long‐standing collaboration between the Torres and Guldi groups has yielded diverse azaporphyrinoid‐based donor‐acceptor nanohybrids with promising applications in solar energy conversion. This conspectus highlights key molecular platforms and structure‐function relationships that govern light and charge management, supporting the rational design of ...
Jorge Labella, Kobra Azizi, Dirk M. Guldi, Tomás Torres   +3 more
wiley   +1 more source

Construction and utilisation of a bidirectional reporter vector in the analysis of two nod-boxes in of Rhizobium loti : a thesis presented in partial fulfilment of the requirements for the Degree of Master of Science in Molecular Genetics at Massey University [PDF]

, 1993
The nod-box is a 47bp cis-acting regulatory region which has been conserved amongst every species of Rhizobium studied to date. In species such as R. meliloti and R.
Parry, Simon Keith
core  

Decoupling Dynamics and Crosslink Stability in Supramolecular Hydrogels Using Associative Exchange

Advanced Materials, EarlyView.
How does reorganization impact the stability of supramolecular hydrogels? In contrast to dissociative crosslink exchange, implementing associative exchange in macroscale DNA hydrogels enables decoupling of reorganization dynamics from thermal and mechanical stability.
Pierre Le Bourdonnec, Charafeddine Ferkous, Léo Comunale, Luca Cipelletti, Rémi Merindol   +4 more
wiley   +1 more source

A Biochar‐Based Composite Hydrogel Microenvironment for Enhanced Biocatalysis

Advanced Materials, EarlyView.
This work presents the synthesis of a polyacrylamide hydrogel wherein biomass‐derived biochar is co‐encapsulated with the enzyme horseradish peroxidase (HRP). The resulting composite hydrogel possesses balanced electron‐rich and electron‐deficient domains, creating an optimal microenvironment that concentrates both hydrogen peroxide and phenol ...
Shengzhe Wang, Jingling Zhu, Weiyang Xue, Yuting Wen, Zhongxing Zhang, Xia Song, Yuan Yu, Chenglin Sun, Huangzhao Wei, Jun Li   +9 more
wiley   +1 more source

Theory of excited state absorptions in phenylene-based $\pi$-conjugated polymers

, 2003
Within a rigid-band correlated electron model for oligomers of poly-(paraphenylene) (PPP) and poly-(paraphenylenevinylene) (PPV), we show that there exist two fundamentally different classes of two-photon A$_g$ states in these systems to which ...
A. Chakrabarti, A. Köhler, A. Mathy, A. Race, Alok Shukla, B. Kraabel, C. Gadermaier, C. Gadermaier, C. Silva, C. Zenz, C.J. Baker, C.W.M. Castleton, D. Beljonne, D. Comoretto, D. Moses, D. Yaron, D.L. Beveridge, E.E. Moore, E.K. Miller, F. Guo, F. Hide, H. Ghosh, Haranath Ghosh, J. Cornil, J.A. Pople, J.G. Müller, J.M. Leng, J.W.P. Hsu, K. Ohno, K. Tandon, M. Chandross, M. Chandross, M. Chandross, M. Chandross, M. Liess, M. Wohlgennant, M. Yan, M.G. Harrison, M.G. Harrison, M.J. Rice, M.Y. Lavrentiev, N. Tessler, P. Tavan, P.B. Miranda, P.C.M. McWilliams, R. Pariser, R. Österbacka, R.H. Friend, R.J. Buenker, S. Abe, S. Mazumdar, S.J. Martin, S.N. Dixit, S.V. Frolov, S.V. Frolov, S.V. Frolov, Sumit Mazumdar, U. Lemmer, V.I. Klimov, Y. Shimoi, Z.G. Soos, Z.G. Soos   +61 more
core   +1 more source