Results 131 to 140 of about 201,093 (287)

A Reliable Strategy to Unravel the Structure and Composition of Semiconducting Conjugated Donor‐Acceptor Block Copolymers

Advanced Science, EarlyView.
This work proposes a reliable strategy to elucidate the structure and composition of conjugated donor‐acceptor block copolymers. The method, based on NMR analysis, allows to extract key structural information such as the number of heterojunctions (NoH) and the number of blocks (NoB) of the copolymers.
Antoine Curé, Pierre‐Alain Bayle, Lucie Rivet, Yann Kervella, Renaud Demadrille, Cyril Aumaître   +5 more
wiley   +1 more source

Scalable Access to N‑Acylindole Linkages: Enabling the Synthesis of Antitrypanosomal Noncanonical Cyclic Peptides for Chagas Disease

Angewandte Chemie, EarlyView.
A gram‐scale supply of bulbiferamide A, which features a rare N‐acylindole linkage and possesses potent inhibitory activity against Trypanosoma cruzi epimastigotes (IC50 = 4.1 µM)—the causative parasite of Chagas disease—was successfully achieved. Moreover, the cyclization strategy developed in this study facilitated the synthesis of noncanonical ...
Jie Zhang, Hugh Nakamura
wiley   +2 more sources

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

Advanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao, Ling Huang, Wenjing Qin, Bin Zhang, Yang Yang, Xue Chen, Xiaoquan Wang, Weilin Zhou, Feiyang Chen, Zhenyu Li, Liyuan Le, Yiqiu Zhang, Zhen Xiang, Lu Zhang, Fei Wang, Dan Lei, Zi‐zhe Cai, Ying Gao, Yong Chen, Xuecen Wang, Junmin Quan, Shuixing Zhang, Xianzhang Bu, Xin Yue   +23 more
wiley   +1 more source

One‐ and Two‐Dimensional Polymorphism in a Hydrogen‐Bonding Bis‐Ureido‐Squaramide

Angewandte Chemie, EarlyView.
A bis‐ureido‐squaramide (USq) is reported to exhibit supramolecular polymorphism driven by hydrogen bonding and π‐stacking interactions. In chloroform solution, the compound exists as a folded monomer that converts into a 2D supramolecular polymer upon increasing concentration.
Inés Capilla, Rosa Gomila, Antoni Frontera, Luis Martínez‐Crespo, Bartolome Soberats   +4 more
wiley   +2 more sources

Specific Phenylpropanoid Oligomerization in a Neutral Environment by the Recombinant Alkaline Laccase from Paramyrothecium roridum VKM F-3565

Biomolecules
Fungal laccases oxidize a wide range of substrates with a diverse spectrum of subsequent non-specific free radical reactions, leading to the production of unwanted byproducts.
Zhanna V. Renfeld, Alexey M. Chernykh, Sofia Yu. Gorina, Boris P. Baskunov, Olga V. Moiseeva, Natalia V. Trachtmann, Shamil Z. Validov, Marina P. Kolomytseva   +7 more
doaj   +1 more source

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

Sequential Homo‐ and Hetero‐Coupling of Isocyanide and Carbon Monoxide Mediated by Acyclic Imino(silyl)Silylene

Angewandte Chemie, EarlyView.
We demonstrate the sequential reactions between an imino(hypersilyl)silylene and aryl isocyanide or carbon monoxide as a molecular‐level model of the Fischer–Tropsch process, providing systematic and detailed insight into C–C bond formation during the homologation of C1 building blocks.
Huaiyuan Zhu, Arseni Kostenko, Xufang Liu, Shigeyoshi Inoue   +3 more
wiley   +2 more sources

Membrane Heteroreceptor Complexes as Second-Order Protein Modulators: A Novel Integrative Mechanism through Allosteric Receptor–Receptor Interactions

Membranes
Bioluminescence and fluorescence resonance energy transfer (BRET and FRET) together with the proximity ligation method revealed the existence of G-protein-coupled receptors, Ionotropic and Receptor tyrosine kinase heterocomplexes, e.g., A2AR–D2R, GABAA ...
Marina Mirchandani-Duque, Malak Choucri, Juan C. Hernández-Mondragón, Minerva Crespo-Ramírez, Catalina Pérez-Olives, Luca Ferraro, Rafael Franco, Miguel Pérez de la Mora, Kjell Fuxe, Dasiel O. Borroto-Escuela   +9 more
doaj   +1 more source

Cell Cycle‐Specific Regulation of Centrosome Clustering Dynamics in Cancer Cells by the Multifunctional Kinesin HSET

Advanced Science, EarlyView.
CDK5RAP2 associates with the kinesin HSET and forms co‐condensates. HSET motors drive the directional transport of CDK5RAP2 condensates toward microtubule minus ends. During mitosis, HSET self‐assembly further stabilizes clustered centrosomes, thereby enabling pseudo‐bipolar spindle formation in cancer cells with supernumerary centrosomes. Upon mitotic
Po‐Pang Chen, Athira Saju, Chia‐Chou Wu, Tzu‐Han Weng, Su‐Yi Tsai, Tzu‐Lun Huang, Jia‐Ying Su, Chien‐Ling Lin, Yu‐Chun Lin, See‐Yeun Ting, Sheng‐hong Chen, Kuo‐Chiang Hsia   +11 more
wiley   +1 more source

Accelerating Biosensor Discovery: A Computationally‐Driven Pipeline for Microplastics Monitoring

Advanced Intelligent Discovery, EarlyView.
A computationally guided pipeline unites molecular simulation, synthetic biology, electrochemical engineering, and machine learning to accelerate biosensor discovery. A Bacillus anthracis carbohydrate‐binding module is used to develop a high‐performance micro‐ and nanoplastics sensor with greatly reduced error and variability.
Gabriel X. Pereira, Marcos de C. Leite, Pedro H. M. Zanineli, Juliana N. Y. Costa, Débora M. Cunha, Sophia P. Serra, Pedro H. Sophia, Flávio M. Shimizu, Yasmin W. Moura, Célio C. Oliveira, Gabriel R. Schleder, Gabriela F. Persinoti, Leandro Merces, Renato S. Lima   +13 more
wiley   +1 more source