Results 111 to 120 of about 629,663 (337)
Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Advanced Functional Materials, EarlyView.Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth +2 more
wiley +1 more source
Software and methods for oligonucleotide and cDNA array data analysis. [PDF]
, 2002 Two HTML-based programs were developed to analyze and filter gene-expression data: 'Bullfrog' for Affymetrix oligonucleotide arrays and 'Spot' for custom cDNA arrays. The programs provide intuitive data-filtering tools through an easy-to-use interface. A
Barlow, Carrolee +5 more
core +1 more source
Smart Nanogels as Enzyme‐Driven Nanomotors for Navigating Viscous Physiological Barriers
Advanced Functional Materials, EarlyView.Two families of urease‐powered nanomotors (NMs), with and without a p‐(2‐hydroxyethyl methacrylate) (p‐HEMA) shell, have been successfully prepared. Both types exhibit effective motion in highly viscous synovial fluid media at low urea concentrations (25 mM).
David Esporrín‐Ubieto +6 more
wiley +1 more source
An electrophoretic investigation of the mixture of oligonucleotides formed by the enzymic degradation of deoxyribonucleic acid by deoxyribonuclease [PDF]
, 1951 A. H. Gordon, Peter Reichard
openalex +1 more source
Advanced Functional Materials, EarlyView.A sequence‐encoded supramolecular construct containing two accessible toeholds is developed herein for enabling multiple editing operations. By introducing specific input strands, it is possible to selectively erase or rewrite digital content through parallel or series toehold‐mediated strand displacement (PTMSD or STMSD).
Jakub Ossowski +3 more
wiley +1 more source
Oligo-PROTAC strategy for cell-selective and targeted degradation of activated STAT3
Molecular Therapy: Nucleic AcidsDecoy oligodeoxynucleotides (ODNs) allow targeting undruggable transcription factors, such as STAT3, but their limited potency and lack of delivery methods hampered translation.
Jeremy Hall +10 more
doaj +1 more source
Improved Performance of Anti-miRNA Oligonucleotides Using a Novel Non-Nucleotide Modifier
Molecular Therapy: Nucleic Acids, 2013 Anti-microRNA oligonucleotides (AMOs) are steric blocking antisense reagents that inhibit microRNA (miRNA) function by hybridizing and repressing the activity of a mature miRNA.
Kim A Lennox +4 more
doaj +1 more source
Advanced Functional Materials, EarlyView.A miniaturized, label‐free, and enzyme‐free biosensor (miR‐TFT) enables direct electrical detection of microRNA (miRNA) with single‐nucleotide specificity and a detection limit of 0.6 fM. Built on a tri‐channel In2O3/ZnO heterojunction and functionalized with bespoke peptide nucleic acid (PNA) probes, the device is robust, reusable, and compatible with
Wejdan S. Al Ghamdi +5 more
wiley +1 more source
Reconfigurable Microenvironments Uncover Mechano‐Sensing Timescales and Direct Cell Polarity
Advanced Functional Materials, EarlyView.A synthetic DNA‐crosslinked cell culture matrix enables control over the mechanical microenvironment surrounding cells. Independent tuning of stiffness and stress relaxation uncovers distinct timescales of mechano‐sensing that regulate cell behavior.
Syuan‐Ku Hsiao +4 more
wiley +1 more source
Cancer Biology & Medicine, 2013 Objective:B-cell lymphoma 2 (Bcl-2) is an important member of the Bcl-2 family of proteins that regulate the induction of apoptosis. This study aims to investigate whether Bcl-2 small interfering RNA (siRNA) combined with miR-15a oligonucleotides (ODN ...
Li Ding +6 more
doaj +1 more source