Results 141 to 150 of about 641,320 (378)

Structure-Specific Cleavage of an RNA Repeat Expansion with a Dimeric Small Molecule Is Advantageous over Sequence-Specific Recognition by an Oligonucleotide

, 2020
Raphael I. Benhamou, Alicia J. Angelbello, Ryan J. Andrews, Eric T. Wang, Walter N. Moss, Matthew D. Disney   +5 more
openalex   +2 more sources

Serotonergic System‐Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy

Advanced Materials, EarlyView.
The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li, Xiaoqing Zhao, Kai Jiang, Haixia Kang, Shuo Liu, Linlin Jiang, Baoshuai Bai, Haonan Cui, Ziyang Zhang, Menglei Dong, Ruizhi Zhang, Chenbo Zou, Shenghui Shang, Chi Zhang, Xiangchuang Fan, Lijuan Zhu, Huiquan Duan, Chuan Zhang, Shiqing Feng, Hengxing Zhou   +19 more
wiley   +1 more source

Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays.

Proceedings of the National Academy of Sciences of the United States of America, 1999
U. Alon, N. Barkai, D. Notterman, K. Gish, S. Ybarra, D. Mach, A. Levine   +6 more
semanticscholar   +1 more source

Diversity and classification of cyclic-oligonucleotide-based anti-phage signalling systems

Nature Microbiology, 2020
A. Millman, S. Melamed, Gil Amitai, R. Sorek   +3 more
semanticscholar   +1 more source

DNA Triplex-Formation by a Covalent Conjugate of the Anticancer Drug Temozolomide

DNA
Background/Objectives: Temozolomide is an important drug used for the treatment of glioblastoma multiforme. Covalent conjugation of temozolomide to triplex-forming oligonucleotides could facilitate better sequence discrimination when targeted to DNA to ...
Andrew J. Walsh, William Fraser
doaj   +1 more source

Mesyl phosphoramidate antisense oligonucleotides as an alternative to phosphorothioates with improved biochemical and biological properties [PDF]

, 2019
С. К. Мирошниченко, Olga Patutina, Е. А. Буракова, Boris P. Chelobanov, А. А. Фокина, Valentin V. Vlassov, Sidney Altman, Marina A. Zenkova, Dmitry A. Stetsenko   +8 more
openalex   +1 more source

Cholesterol‐DNA Origami Nanostructures for Synthetic Lipid Rafts Induce Early T Cell Activation Signals

Advanced Materials Interfaces, EarlyView.
Here, we present a nanotechnology approach to construct synthetic lipid rafts on the live T cell membrane, leveraging a versatile DNA origami‐enabled platform named as the “cholesterol nano‐patch” (CNP). Our investigation highlights the effectiveness of DNA nanotechnology in exploring the impact of nanoscale arrangement of cholesterols on the ...
Yunmin Jung, Young‐Joo Kim, Kunwoo Noh, Sunmi Lee, Minsuk Kwak   +4 more
wiley   +1 more source

Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection.

Proceedings of the National Academy of Sciences of the United States of America, 2001
Cheng Li, W. Wong
semanticscholar   +1 more source

Systems Biology and the Development of Vaccines and Drugs for Malaria Treatments [PDF]

, 2006
The sequencing race has ended and the functional race has already begun. Microarray technology enables simultaneous gene expression analysis of thousands of genes, enabling a snapshot of an organisms’ transcriptome at an unprecedented resolution.
Adebiyi, E. F.
core   +1 more source

Inhibition of tumor growth and metastasis with antisense oligonucleotides (Cantide) targeting hTERT in an in situ human hepatocellular carcinoma model [PDF]

, 2005
Ruxian Lin, Chao-wei Tuo, Qiujun Lu, Wei Zhang, Shengqi Wang   +4 more
openalex   +1 more source