Results 201 to 210 of about 635,743 (331)

Targeting of the Transcription Factor STAT4 by Antisense Phosphorothioate Oligonucleotides Suppresses Collagen-Induced Arthritis [PDF]

, 2007
Kai Hildner, Peter Schirmacher, Imke Atreya, Maria Dittmayer, Brigitte Bartsch, Peter R. Galle, Stefan Wirtz, Markus F. Neurath   +7 more
openalex   +1 more source

Figure S3 from Radiotherapy Combined with Novel STING-Targeting Oligonucleotides Results in Regression of Established Tumors

, 2023
Jason R. Baird, David S. Friedman, Benjamin Cottam, Thomas W. Dubensky, David B. Kanne, Shelly Bambina, Keith S. Bahjat, Marka R. Crittenden, Michael J. Gough   +8 more
openalex   +1 more source

Clinofibrate Disrupts the SNORA80B/YTHDC1‐Driven M6A Modification to Suppress Cholesterol Metabolism and Cisplatin Resistance in ESCC

Advanced Science, EarlyView.
This study uncovers a non‐canonical role of SNORA80B in ESCC, showing it mediates AR‐driven metabolic reprogramming via N⁶‐methyladenosine (m6A) methylation. By binding YTHDC1, SNORA80B stabilizes cholesterol‐metabolic enzyme mRNAs and promotes tumor progression. The FDA‐approved drug clinofibrate inhibits SNORA80B by disrupting cholesterol homeostasis,
Hongyu Yuan, Ge Ge, LiQiu Liu, Sijun Hu, Miaomiao Tian, Yongzhan Nie, Zitong Zhao, Yongmei Song   +7 more
wiley   +1 more source

A Rapid, High-Throughput Method for the Construction of Mutagenesis Libraries. [PDF]

Biomolecules
Lu Y, Meng S, Guan X, He P, Zhao D.
europepmc   +1 more source

Organization of the AKR Qa region [PDF]

, 1989
Bevec, Dorian, Grosshaus, C., Messer, Gerald, Schmidt, Walter, Schwemmle, Sabine, Steinmetz, M., Weiss, Elisabeth H.   +6 more
core   +1 more source

Effect of terminal phosphate groups on collisional dissociation of RNA oligonucleotide anions [PDF]

Mei-Qing Zuo, Ge Song, Meng‐Qiu Dong, Rui-Xiang Sun   +3 more
openalex   +1 more source

Combining gene expression data from different generations of oligonucleotide arrays [PDF]

, 2004
Kyu‐Baek Hwang, Sek Won Kong, Steve A Greenberg, Peter J. Park   +3 more
openalex   +1 more source

DCAF12 Ubiquitin Ligase Promotes Lung Cancer Metastasis by Modulating the TRiC/CCT Chaperonin Complex

Advanced Science, EarlyView.
This study elucidates how DCAF12 facilitates non‐degradative ubiquitination to stabilize TRiC/CCT, thereby enhancing the folding capacity of chaperonins. This mechanism promotes the maturation of cytoskeletal proteins and activates key oncogenic drivers, including YAP, STAT3, and mTOR, ultimately driving metastatic progression in lung cancer.
Zhenyi Wang, Huanhuan Huang, Kaizong Huang, Xiaowen Cui, Leilei Wu, Renyu Lin, Zhe Zhao, Hua Chen, Cheng Zheng, Weilin Jin, Song Chen, Jiayan Chen, Yaping Xu, Dongping Wei   +13 more
wiley   +1 more source

Thymidine-Inosine Dimer Building Block for Reversible Modification of Synthetic Oligonucleotides. [PDF]

Molecules
Kolganova NA, Varizhuk IV, Stomakhin AA, Khisamov MM, Solyev PN, Surzhikov SA, Timofeev EN.   +6 more
europepmc   +1 more source

An Aptamer‐Based EXACT Anticoagulant as a Sustainable, Animal‐Free Alternative to Unfractionated Heparin

Advanced Science, EarlyView.
By simply conjugating thrombin's active‐site inhibitor, dabigatran, with an exosite inhibitor, aptamer HD1, the resulting EXosite‐ACTive site (EXACT) inhibitors show two orders of magnitude higher potency and selectivity via synergistic binding, while maintaining the aptamer's antidote‐reversible trait, yielding a potential substitute for the animal ...
Haixiang Yu, George Pitoc, Manqi Zhang, Jeffrey Clancy, James Frederiksen, Amy Yan, Samuel Francis, Rebecca Sullenger, Rachel Rempel, Susannah Gammell, Jillian Caiazzi, Bruce A. Sullenger   +11 more
wiley   +1 more source