Results 231 to 240 of about 641,320 (378)

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

Advanced Science, EarlyView.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao, Liqun Zhou, Minhua Zhou, Yu Fang, Haiying Mai, Lingbo Cao, Kun Xu, Yuan Sang, Minyi Chen, Jiewei Huang, Peiyi Huang, Zhipeng Yan, Chao Wang, Zhangshuai Dai, Dichun Huang, Ronghan He, Lijuan Pang, Yunmiao Guo, Ting Gang Chew, Junqi Huang   +19 more
wiley   +1 more source

Light-generated oligonucleotide arrays for rapid DNA sequence analysis.

Proceedings of the National Academy of Sciences of the United States of America, 1994
A. C. Pease, D. Solas, E. Sullivan, M. Cronin, C. Holmes, S. P. Fodor   +5 more
semanticscholar   +1 more source

Auto-luminescence study of thermal unfolding of DNA G-quadruplexes. [PDF]

RSC Adv
Kudrya VY, Dubey IY, Negrutska VV, Naumenko AP.   +3 more
europepmc   +1 more source

The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)–fold structure

, 2012
Cassandra Adams, A.C.W. Pike, Sandra Maniam, Timothy Sharpe, Amanda S. Coutts, Stefan Knapp, Nicholas B. La Thangue, Alex N. Bullock   +7 more
openalex   +2 more sources

Functional, Pharmacogenomic, and Immune Landscapes of Long Non‐Coding RNAs in Cancer

Advanced Science, EarlyView.
A systematic analysis of 33 cancer types reveals widespread associations between lncRNAs and cancer pathways, drug responses, immune features, and immunotherapy outcomes. The study identifies key lncRNAs linked to therapeutic response and adverse events and introduces PILNC, an interactive web portal for exploring the functional, pharmacogenomic, and ...
Runhao Wang, Mei Luo, Yuan Liu, Jingwen Yang, Yamei Chen, Chengxuan Chen, Lifei Ma, Stephanie Ding, James Wengler, Yong Zang, Bora Lim, Wenbo Li, Liuqing Yang, Chunru Lin, Lixia Diao, Leng Han   +15 more
wiley   +1 more source

Factor XI antisense oligonucleotide for prevention of venous thrombosis.

New England Journal of Medicine, 2014
H. Büller, C. Bethune, S. Bhanot, D. Gailani, B. Monia, G. Raskob, A. Segers, P. Verhamme, J. Weitz   +8 more
semanticscholar   +1 more source

Corrigendum: <i>Rhodococcus parequi</i> sp. nov., a new species isolated from equine farm soil closely related to the pathogen <i>Rhodococcus equi</i>. [PDF]

Int J Syst Evol Microbiol
Vázquez-Boland JA, Val-Calvo J, Duquesne F, Decorosi F, Viti C, Petry S, Scortti M.   +6 more
europepmc   +1 more source

Learned Conformational Space and Pharmacophore Into Molecular Foundational Model

Advanced Science, EarlyView.
The Ouroboros model introduces two orthogonal modules within a unified framework that independently learn molecular representations and generate chemical structures. This design enables flexible optimization strategies for each module and faithful structure reconstruction without prompts or noise.
Lin Wang, Yifan Wu, Hao Luo, Minglong Liang, Yihang Zhou, Cheng Chen, Chris Liu, Jun Zhang, Yang Zhang   +8 more
wiley   +1 more source

Single-molecule electrical protein fingerprinting in solid-state nanopores. [PDF]

Clin Transl Med
Soni N, Meller A.
europepmc   +1 more source

Anti-gene oligonucleotide clamps invade dsDNA and downregulate huntingtin expression

Tea Umek, Karin E. Lundin, Metoboroghene O. Mowoe, Yi Hao, Samantha Roudi, Lana Žura, Per T. Jørgensen, Chenguang Lou, Daniel W. Hagey, Jesper Wengel, Smith Rjh, Rula Zain   +11 more
openalex   +1 more source