Results 231 to 240 of about 523,140 (287)

The chemistry of oligonucleotide phosphotriesters and phosphoramidates

, 1978
Robert L. Letsinger
openalex   +2 more sources

Progastrin Promotes Colorectal Cancer Stem Cell‐Like Properties via the Receptor PZR

Advanced Science, EarlyView.
The tumor microenvironment supports colorectal cancer (CRC) progression by maintaining cancer stem cells (CSCs) through progastrin (PG). This study identifies Protein Zero‐Related protein (PZR) as an essential receptor for PG activity, promoting CSC‐like signaling via SHP2/SRC/β‐catenin.
Julie Nguyen, Marie Lafitte, Maud Barbery, Kevin Espie, Maya Jeitany, Romain Larive, Jihane Vitre, Conception Paul, Yvan Boublik, Elise Fourgous, Valérie Simon, Audrey Sirvent, Madeline Neiveyans, Steeve Thirard, Lucile Bansard, Morgan Maillard, Nathalie Coutry, Jacques Colinge, Philippe Jay, Pierre Martineau, Michael Hahne, Julie Pannequin, Serge Roche   +22 more
wiley   +1 more source

Diffdigester.uni-jena.de: a tool for optimized selection of restriction enzymes for plasmid identification in cloning procedures. [PDF]

Nucleic Acids Res
Gühmann M, Reuter S, Mrowka R.
europepmc   +1 more source

Primer‐Disk‐Enabled DNA Data Storage System with Index and Record‐Many‐Read‐Many Features

Advanced Science, EarlyView.
A primer‐disk‐enabled DNA data storage system is introduced, which allows for append‐recording of DNA files on demand, retrieval via inkjet printed QR code, and multiple ramdom read of DNA information via solid‐phase PCR. The hiearchical system with index and record‐many‐read‐many features paves the way for the practical use of DNA data storage ...
Jiaxiang Ma, Yu Yang, Ben Pei, Shengli Mi, Zhuo Xiong, Liliang Ouyang   +5 more
wiley   +1 more source

Engineered Cas12j‐8 is a Versatile Platform for Multiplexed Genome Modulation in Mammalian Cells

Advanced Science, EarlyView.
Engineered through structure‐guided protein engineering, enCas12j‐8 significantly enhances the editing efficiency of compact Cas12j‐8 while maintaining high specificity. It enables efficient multiplexed genome editing and base editing using a single crRNA array, demonstrating broad applicability and therapeutic potential in genome engineering ...
Ru Meng, Jiayao Li, Wuke Wang, Dong Liang, Zhanwei Li, Cong Mao, Qingyang Li, Yu Zhang, Hao Chen, Jin Tang, Ping Hu, Qi Niu, Xingxu Huang, Bin Shen, Jun Zhang   +14 more
wiley   +1 more source

An Aqueous-Compatible On-Column Approach for the Conjugation of Nucleic Acids Using Amino Modifiers. [PDF]

Curr Protoc
Saraya JS, O'Flaherty DK.
europepmc   +1 more source

Intermolecular exon ligation of the rRNA precursor of tetrahymena: Oligonucleotides can function as 5′ exons

, 1985
Tan Inoue, Francis X. Sullivan, Thomas R. Cech   +2 more
openalex   +1 more source

Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment

Advanced Science, EarlyView.
KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma, Shenao Fu, Jun Tan, Ying Han, Yihong Chen, Xiangying Deng, Hong Shen, Shan Zeng, Yinghui Peng, Changjing Cai   +9 more
wiley   +1 more source