Results 241 to 250 of about 635,743 (331)

Activation of enzymatic catalysis via nucleic acid hybridization affords synergistic coupling of specificity, potency, and signal amplification. [PDF]

Nat Commun
Montasell MC, Raeven LMV, Ravn Malm M, van Hest JCM, Zelikin AN.   +4 more
europepmc   +1 more source

Corrigendum to “Antisense Oligonucleotide Mediated Splice Correction of a Deep Intronic Mutation in OPA1”

, 2016

openalex   +1 more source

Oligonucleotide [PDF]

, 2020
openaire   +1 more source

ITM2B Truncation Promotes Migrasome Formation to Accelerate Renal Cell Carcinoma Growth

Advanced Science, EarlyView.
This study identifies truncated ITM2B as a regulator of migrasome formation in renal cell carcinoma (RCC) cells. The ITM2B truncation not only facilitates migrasome formation by recruiting TSPAN4, but also sorts active caspase‐7 into migrasomes. The internalization of active caspase‐7‐enriched migrasomes by macrophages stimulates IL‐6 secretion to ...
Qi‐tao Chen, Qiao‐ling Huang, Ming‐zhi Han, Xue‐hui Hong, De‐yi Feng, Lu‐ming Yao, Wen‐bin Hong, Yue Chen, Ya‐ying Huang, Hang‐zi Chen, Qiao Wu   +10 more
wiley   +1 more source

Use of a Dihydroxyacetone Derivative as Protecting Reagent to Phosphorylate Oligonucleotides. [PDF]

Curr Protoc
Lartia R.
europepmc   +1 more source

Modulating a Massive Set of Biomolecular Structures by Sono‐Mechanical Force

Advanced Science, EarlyView.
Using low‐power ultrasound exposure, picoNewton forces are generated to release loaded drugs after unfolding secondary structures in DNA nanoassemblies. This opens a door to reversibly manipulate a large set of biomolecular structures both inside and outside cells without the damages incurred by high‐power sonications currently used in the field ...
Pravin Pokhrel, Grinsun Sharma, Jaren Jenyk, Alyssa Lower, Jiahao Ji, Sajan Shakya, Joseph Haun, Hanbin Mao   +7 more
wiley   +1 more source

Separation of PS diastereomers in GalNAc-conjugated siRNA-a comparative study of chromatographic and ion mobility mass spectrometry approaches. [PDF]

Anal Bioanal Chem
Bill MK, Graglia M, Riley JA, Zugaj M, Demtschenko N, Fox J, Bethge L, Smink JJ, Manz C.   +8 more
europepmc   +1 more source

Soybean Auxin Transporter PIN3 Regulates Nitrate Acquisition to Improve Nitrogen Use and Seed Traits

Advanced Science, EarlyView.
Xu et al. discovers that switching off auxin transporters in soybean, PIN3a and PIN3b, disrupts auxin flow; this triggers ARF‐STF3/4 signal cascade to activate the nitrate importer NPF2.13 and soil nitrogen acquisition. Multi‐year field trials show edited soybeans maintain yield with higher oil content, offering a potential genetic route to improve ...
Huifang Xu, Shiyu Huang, Jie Wang, Tian Wang, Qingqing Han, Kexin Wu, Zhen Gao, Xiaolei Shi, Tianli Tu, Ming Wang, Laimei Huang, Jiaomei Chen, Yunqi Liu, Yumei Zhang, Guoqiang Lin, Zhichang Chen, Xu Chen   +16 more
wiley   +1 more source

Synthesis, Biological Activity, and Molecular Dynamics Simulations of LNA-Charge Neutral Linkages for Enhanced Splice-Switching Antisense Oligonucleotides. [PDF]

Angew Chem Int Ed Engl
Kennett A, Lie L, Flerin M, Kurt BZ, Baker YR, Hill AC, Ramesh A, Wood MJA, Dhara D, El-Sagheer AH, Duarte F, Brown T.   +11 more
europepmc   +1 more source