Results 251 to 260 of about 523,140 (287)

Chemical autoligation with phosphorothioate- and sulfonamide-terminated DNA via intramolecular cross-activation. [PDF]

Commun Chem
Yokoe H, Kokubo K, Yamaoka K, Oikawa R, Tomoike F, Abe N, Kimura Y, Abe H.   +7 more
europepmc   +1 more source

Machine Learning‐Enhanced Nanoparticle Design for Precision Cancer Drug Delivery

Advanced Science, EarlyView.
Machine Learning (ML) is revolutionizing cancer nanomedicine by optimizing nanoparticle (NP) design and drug delivery. This review summarizes ML applications across all stages of NP drug delivery, along with a discussion of ongoing challenges and future directions.
Qingquan Wang, Yujian Liu, Chenchen Li, Bin Xu, Shidang Xu, Bin Liu   +5 more
wiley   +1 more source

Oligo-seq protocol for mapping DNA motifs targeted by base editors. [PDF]

STAR Protoc
Ortega P, Sanchez A, Seldin M, Buisson R.   +3 more
europepmc   +1 more source

Sequence-specific intercalating agents: intercalation at specific sequences on duplex DNA via major groove recognition by oligonucleotide-intercalator conjugates.

, 1989
Jian‐Sheng Sun, Jean‐Christophe François, Thérèse Montenay-Garestier, Tula Saison‐Behmoaras, Véronique Roig, Nguyen T. Thuong, C. Hélène   +6 more
openalex   +1 more source

Splicing Shift of RAC1 Accelerates Tumorigenesis and Defines a Potent Therapeutic Target in Lung Cancer

Advanced Science, EarlyView.
Dysregulated RNA splicing is an underappreciated molecular feature of cancer. By integrating murine and cellular models with patient specimens of lung adenocarcinoma, this study demonstrates that RAC1B, rather than RAC1A isoform, promotes tumorigenesis and presents a potent therapeutic target for lung cancer. Mechanistically, RAC1B preferentially binds
Yueren Yan, Ning Wang, Bowen Xing, Min Yang, Jun Shang, Yufang Bao, Lixing Xiao, Ningxia Zhang, Yunpeng Ren, Chunnan Liu, Yuting Chen, Han Han, Yunjian Pan, Lei Lv, Wei‐Xing Zong, Hongbin Ji, Changyou Zhan, Zefeng Wang, Haiquan Chen, Yongbo Wang   +19 more
wiley   +1 more source

Nuclear Retention of mRNAs Through Paraspeckle Protein Binding to a Sequence Determinant in 3'UTR. [PDF]

Int J Mol Sci
Jacq A, Becquet D, Boyer B, Guillen S, Bello-Goutierrez MM, Blanchard MP, Villard C, Belghazi M, Torres M, Franc JL, François-Bellan AM.   +10 more
europepmc   +1 more source

Neutrophil Mobilization Triggers Microglial Functional Change to Exacerbate Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
These study underscores the pivotal role of neutrophil‐derived myeloid‐related protein 14 (MRP14) in the pathophysiology of acute ischemic stroke (AIS). MRP14 not only disrupts mitochondrial function, thereby inhibiting microglial phagocytosis of neutrophils, but also activates microglial pyroptosis, exacerbating neuroinflammation following AIS ...
Huijuan Jin, Zhifang Li, Senwei Tan, Qinghui Xiao, Qingcan Li, Jiao Ye, Yifan Zhou, Yan Wan, Qiang Liu, Bijoy K Menon, Bo Hu   +10 more
wiley   +1 more source

Antisense oligonucleotide therapies for monogenic disorders. [PDF]

Med Genet
Krey-Grauert I, Ferro I, Wagner M.
europepmc   +1 more source

STK25 Loss Augments Anti‐PD‐1 Therapy Efficacy by Regulating PD‐L1 Stability in Colorectal Cancer

Advanced Science, EarlyView.
This study demonstrates that STK25 depletion facilitates CRC immune escape through the inhibition of PD‐L1 Ser283 phosphorylation‐mediated ubiquitination, and promotes tumor growth. Furthermore, these findings identify STK25 as a potential therapeutic target to trigger antitumor immunity and promote immunotherapy efficacy. Abstract Tumor immune evasion
Xiaowen Qiao, Pu Xing, Hao Hao, Jiangbo Chen, Lin Song, Yifan Hou, Xinying Yang, Kai Weng, Jie Chen, Pin Gao, Tongkun Song, Hong Yang, Tianqi Liu, Yumeng Ran, Bo Chen, Wei Zhao, Jiabo Di, Zaozao Wang, Jun Zhang, Xiangqian Su, Beihai Jiang   +20 more
wiley   +1 more source