Results 261 to 270 of about 641,320 (378)
No Effect of Immunogenicity on Pharmacokinetics, Efficacy, and Safety of the Oligonucleotide Telomerase Inhibitor Imetelstat in Lower-Risk Myelodysplastic Syndromes. [PDF]
Clin Transl SciLennox AL +7 more
europepmc +1 more source
Therapeutic Potential of Splice-Switching Oligonucleotides
, 2009 John A. Bauman +2 more
openalex +1 more source
GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer
Advanced Science, EarlyView.Aberrant glycosylation drives cancer progression, yet its role in the tumor microenvironment remains unclear. We developed GlycoChat to map glycan–lectin circuits at single‐cell resolution. We discovered that cancer cells induce immunosuppressive macrophage differentiation and impair phagocytosis through interactions with CLEC10A and SIGLEC3 ...
Dinh Xuan Tuan Anh +8 more
wiley +1 more source
Local dystrophin restoration with antisense oligonucleotide PRO051.
New England Journal of Medicine, 2007 J. V. van Deutekom +15 more
semanticscholar +1 more source
Unveiling the potential of antisense oligonucleotides: Mechanisms, therapies, and safety insights [PDF]
Edanur Ersöz, Devrim Demir Dora
openalex +1 more source
Advanced Science, EarlyView.This study shows that Salmonella VNP20009 recruits pro‐tumor neutrophils that reduce its anticancer efficacy. Combining VNP with amodiaquine selectively eliminates these neutrophils by targeting glutathione reductase. A GR‐shRNA‐loaded VNP strain was further developed, demonstrating an innovative strategy integrating drug repurposing with synthetic ...
Wanfa Dong +13 more
wiley +1 more source
Sequence-specific fluorescence turn-on arises from base pairing-templated tautomerism in the tricyclic cytidine analogue <sup>DEA</sup>tC. [PDF]
RSC Chem BiolShalamberidze A +3 more
europepmc +1 more source
An expedient biocatalytic procedure for abasic site precursors useful in oligonucleotide synthesis
, 2011 Saúl Martínez‐Montero +4 more
openalex +2 more sources
Advanced Science, EarlyView.To distinguish how Salmonella invades cells vs how it survives long‐term, a parallel CRISPR screening platform is developed. This approach reveals the host proteins that the bacterium exploits at different stages of infection. The study identifies SORL1 as a novel host factor for invasion and demonstrates that blocking it with an antibody effectively ...
Sehee Yun +6 more
wiley +1 more source
Advanced Science, EarlyView.PURH is constructed by a five‐layer upconversion nanoparticle (UCNP) surface coated with mesoporous silica, which encapsulates rose bengal (RB) within the mesoporous channels. Additionally, CpG oligonucleotides (CpG ODN) is linked to the surface, followed by the surface functionalization of hyaluronic acid (HA). This spatiotemporally controllable smart
Fang Wang +9 more
wiley +1 more source