Results 271 to 280 of about 635,743 (331)

A Biosensor Platform for Detecting the Dissipation of Transmembrane Gradients in Single Liposomes. [PDF]

Anal Chem
Zhang C, Bowen ME.
europepmc   +1 more source

GLUL Confers Perivascular Cancer‐Associated Fibroblasts With Pro‐Angiogenic Capacity to Promote Glioma Progression

Advanced Science, EarlyView.
Schematic illustration of the proposed model. Primary CAFs are isolated from fresh human GBM specimens according to established protocols. GLUL is essential for pro‐angiogenic capacity of CAFs through its impact on the PI3K/AKT pathway. GLUL enhances the pro‐angiogenic capacity of CAFs, driving aberrant tumor vasculature that fuels tumor growth ...
Qing Zhang, Yida Liu, Zhi Zhang, Yang Wang, Fusheng Liu   +4 more
wiley   +1 more source

Multimodal glioma immunotherapy combining TLR9-targeted STAT3 antisense oligodeoxynucleotides with PD1 immune checkpoint blockade. [PDF]

Neuro Oncol
Hung CY, Kang EY, Jacek K, Yu C, Zhang X, Zhu Y, Aftabizadeh M, Wong RA, Badie B, Świderski P, Kamińska B, Alizadeh D, Heimberger AB, Brown CE, Kortylewski M.   +14 more
europepmc   +1 more source

DNA Origami and Its Applications in Synthetic Biology

Advanced Science, EarlyView.
This review provides a comprehensive summary of recent advancements in DNA origami for synthetic biology, emphasizing two key areas: the precise construction and dynamic regulation of extracellular‐to‐intracellular, and the synergistic integration with cell‐free systems.
Yaning Fang, Xuexin Chen, Qingsheng Qi, Min Lin, Quanfeng Liang   +4 more
wiley   +1 more source

An electrophoretic mobility shift assay with chemiluminescent readout to evaluate DNA-targeting oligonucleotide-based probes. [PDF]

PLoS One
Everly ME, Wieber PJ, Al Janabi I, Hrdlicka PJ.   +3 more
europepmc   +1 more source

NUSAP1 Recruits DAXX to Suppress HIF‐Driven Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
A double‐negative feedback loop is identified in TNBC where NUSAP1 bridges HIF and DAXX via its microtubule‐associated domain (MAD) to recruit SETDB1, repressing HIF transcriptional activity by depositing the H3K9me3 repressive mark on HIF target genes, while HIF itself suppresses NUSAP1.
Yating Du, Jingjing Wang, Min Wang, Yao Zhang, Miaomiao Zheng, Huiyan Li, Xuemeng Wang, Huanran Sun, Kexin Tang, Changliang Shan, Qiang Zhao, Xiaoqian Meng, Yijie Wang, Jun Zhou, Yan Chen   +14 more
wiley   +1 more source

Thiol-mediated uptake of phosphorothioate liposomes, visualized with fluorescent flippers. [PDF]

Chem Sci
Bouffard J, Bayard F, Sakai N, Matile S.
europepmc   +1 more source

Methodologies for Sample Multiplexing and Computational Deconvolution in Single‐Cell Sequencing

Advanced Science, EarlyView.
Sample multiplexing offers a critical solution for boosting throughput and minimizing batch effects in single‐cell sequencing. This review navigates the latest experimental methodologies and computational deconvolution algorithms, bridging the gap between wet‐lab design and analytical success.
Yufei Gao, Weiwei Yin, Wei Hu, Wei Chen
wiley   +1 more source

Increasing Oligonucleotide Sequencing Information and Throughput with Ion Mobility Spectrometry-Mass Spectrometry. [PDF]

J Am Soc Mass Spectrom
Ryan JP, Slysz GW, Rye P, Stow SM, Dodds JN, Sausen J, Baker ES.   +6 more
europepmc   +1 more source

Functional, Pharmacogenomic, and Immune Landscapes of Long Non‐Coding RNAs in Cancer

Advanced Science, EarlyView.
A systematic analysis of 33 cancer types reveals widespread associations between lncRNAs and cancer pathways, drug responses, immune features, and immunotherapy outcomes. The study identifies key lncRNAs linked to therapeutic response and adverse events and introduces PILNC, an interactive web portal for exploring the functional, pharmacogenomic, and ...
Runhao Wang, Mei Luo, Yuan Liu, Jingwen Yang, Yamei Chen, Chengxuan Chen, Lifei Ma, Stephanie Ding, James Wengler, Yong Zang, Bora Lim, Wenbo Li, Liuqing Yang, Chunru Lin, Lixia Diao, Leng Han   +15 more
wiley   +1 more source