Results 271 to 280 of about 523,140 (287)

Axonal tau reduction ameliorates tau and amyloid pathology in a mouse model of Alzheimer's disease. [PDF]

Transl Neurodegener
Zare A, Salehi S, Bader JM, Wiessler AL, Prokesch M, Albrecht V, Villmann C, Mann M, Briese M, Sendtner M.   +9 more
europepmc   +1 more source

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source

Engineering of Small Ribozymes Acting on RNA: What is Needed to Make a New Function Work with an Existing Catalyst? [PDF]

Chembiochem
Ebermann C, Müller S.
europepmc   +1 more source

Lysosome‐Featured Cell Aggregate‐Released Extracellular Vesicles Regulate Iron Homeostasis and Alleviate Post‐Irradiation Endothelial Ferroptosis for Mandibular Regeneration

Advanced Science, EarlyView.
Lysosomal redistribution occurs via extracellular vesicles in multi‐stem cell aggregates and controls iron homeostasis for safeguarding cell aggregation. These cell aggregate‐released extracellular vesicles (CA‐EVs) rescue lysosomal impairments and exert anti‐ferroptosis effects in recipient irradiated endothelial cells.
Yuan‐Yuan Li, Bo Ma, Jia‐Wei Lu, Kai‐Chao Zhang, Chao Ma, Sheng‐Feng Bai, Yan‐Jiao Li, Si‐Qi Ying, Wei‐Zong Weng, Kai Zhang, Xi‐Wang Hu, Rang Li, Chen‐Xi Zheng, Xiao‐Ru Xu, Ji Chen, Fang Jin, Hao‐Kun Xu, Jian‐Wei Xie, Yan Jin, Yi Shuai, Bing‐Dong Sui   +20 more
wiley   +1 more source

Development and validation of nanoplate-based RT-dPCR assay for canine respiratory coronavirus detection in various clinical samples. [PDF]

BMC Vet Res
Poonsin P, Wiwatvisawakorn V, Piewbang C, Techangamsuwan S.   +3 more
europepmc   +1 more source

Advancements in DNA‐Driven Precision Modulation of Cell Surface Receptor for Programmable Cellular Functions

Advanced Science, EarlyView.
DNA‐Based Genetic and Non‐Genetic Tools for Receptor Engineering. This review highlights recent advances in DNA‐based strategies for receptor engineering, including genetic approaches like domain fusion and site‐directed mutagenesis, as well as non‐genetic methods using functional nucleic acids, DNA nanostructures, and dynamic DNA reactions.
Hexin Nan, Ming Cai, Yiyu Wang, Hong‐Hui Wang, Zhou Nie   +4 more
wiley   +1 more source

Modified Bis-pyrimidine Clamps for Triplex Formation and Their Use in SARS-CoV‑2 Detection. [PDF]

ACS Omega
Domínguez A, Gargallo R, Cuestas-Ayllón C, Gomez-Pinto I, Fàbrega C, de la Fuente JM, Damha MJ, González C, Eritja R, Aviñó A.   +9 more
europepmc   +1 more source

Nonenzymatic Primer Extension Experiments in the Presence of Coacervates. [PDF]

Curr Protoc
Robinson JD, O'Flaherty DK.
europepmc   +1 more source

In Vitro Structure-Activity Relationship Stability Study of Antisense Oligonucleotide Therapeutics Using Biological Matrices and Nucleases. [PDF]

Pharmacol Res Perspect
Lovrić J, Yan J, Li X, Karlsborn T, Bood M, Dahlén A, Hilgendorf C, Bhatt DK.   +7 more
europepmc   +1 more source