Results 81 to 90 of about 631,998 (390)

Downregulation of Akt1 Inhibits Anchorage-Independent Cell Growth and Induces Apoptosis in Cancer Cells

Neoplasia: An International Journal for Oncology Research, 2001
The serine/threonine kinases, Akti/PKBα, Akt2/PKBβ, and Akt3/PKBγ, play a critical role in preventing cancer cells from undergoing apoptosis. However, the function of individual Akt isoforms in the tumorigenicity of cancer cells is still not well defined.
Xuesong Liu, Yan Shi, Edward K.-H. Han, Zehan Chen, Saul H. Rosenberg, Vincent L. Giranda, Yan Luo, Shi-Chung Ng   +7 more
doaj   +1 more source

The Evolution of Antisense Oligonucleotide Chemistry—A Personal Journey

Biomedicines, 2021
Over the last four decades, tremendous progress has been made in use of synthetic oligonucleotides as therapeutics. This has been possible largely by introducing chemical modifications to provide drug like properties to oligonucleotides.
Sudhir Agrawal
doaj   +1 more source

Mechanisms of base selection by human single-stranded selective monofunctional uracil-DNA glycosylase [PDF]

, 2009
hSMUG1 (human single-stranded selective monofunctional uracil-DNA glyscosylase) is one of three glycosylases encoded within a small region of human chromosome 12. Those three glycosylases, UNG (uracil-DNA glycosylase), TDG (thymine-DNA glyscosylase), and
Agus Darwanto, Akbari, Alcantara, Barrett, Bennett, Bethod, Boorstein, Bryantsev, Cerny, Clough, Cui, Cybulski, Daniel K. Rogstad, Di Noia, Di Noia, Dunning, Fujimoto, Gait, Guerniou, Hansch, Haushalter, Hobza, Jacob A. Theruvathu, James L. Sowers, Jang, Kavli, Kelly, Kendall, Krokan, Krokan, La Francois, Lawrence C. Sowers, Liu, Marten, Masaoka, Matsubara, Matsubara, Matsudaira, Mendes, Morgan, Neddermann, Nilsen, Nilsen, Pearl, Perezjorda, Privat, Rao, Rogstad, SantaLucia, Sibghat-Ullah, Slupphaug, Sousa, Sowers, Sowers, Sugiyama, Tannor, Tod Pascal, Waters, Wibley, William Goddard, Zhao, Zhao, Zhao, Zielenkiewicz   +63 more
core   +3 more sources

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

i-Genome: A database to summarize oligonucleotide data in genomes

BMC Genomics, 2004
Background Information on the occurrence of sequence features in genomes is crucial to comparative genomics, evolutionary analysis, the analyses of regulatory sequences and the quantitative evaluation of sequences.
Chang Yu-Chung, Huang Hsien-Da, Lin Feng-Mao, Horng Jorng-Tzong   +3 more
doaj   +1 more source

Chemical Manipulation of the Endosome Trafficking Machinery: Implications for Oligonucleotide Delivery

Biomedicines, 2021
Antisense oligonucleotides (ASOs), siRNA and splice switching oligonucleotides (SSOs) all have immense potential as therapeutic agents, potential that is now being validated as oligonucleotides enter the clinic. However, progress in oligonucleotide-based
Rudolph L. Juliano
doaj   +1 more source

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

Molecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo, Yoshihiro Mezawa, Zixu Wang, Ahmet Acar, Yasuhiko Ito, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Yataro Daigo, Takuya Shirakihara, Akira Orimo   +11 more
wiley   +1 more source

Synthetic incorporation of Nile Blue into DNA using 2′-deoxyriboside substitutes: Representative comparison of (R)- and (S)-aminopropanediol as an acyclic linker

Beilstein Journal of Organic Chemistry, 2010
The Nile Blue chromophore was incorporated into oligonucleotides using “click” chemistry for the postsynthetic modification of oligonucleotides. These were synthesized using DNA building block 3 bearing an alkyne group and reacted with the azide 4. (R)-3-
Daniel Lachmann, Sina Berndl, Otto S. Wolfbeis, Hans-Achim Wagenknecht   +3 more
doaj   +1 more source

Twenty Years of Research on Cyclodextrin Conjugates with PAMAM Dendrimers

Pharmaceutics, 2021
Recently, the number of gene and oligonucleotide drugs are increasing. Of various drug delivery systems (DDSs) for gene and oligonucleotide drugs, few examples of the clinical application of polymer as drug carriers are known, despite development of the ...
Hidetoshi Arima
doaj   +1 more source

Antisense oligonucleotide therapy for spinocerebellar ataxia type 2

Nature, 2017
There are no disease-modifying treatments for adult human neurodegenerative diseases. Here we test RNA-targeted therapies in two mouse models of spinocerebellar ataxia type 2 (SCA2), an autosomal dominant polyglutamine disease.
Daniel R. Scoles, P. Meera, Matthew Schneider, S. Paul, W. Dansithong, K. Figueroa, G. Hung, F. Rigo, C. F. Bennett, Thomas S. Otis, Stefan M. Pulst   +10 more
semanticscholar   +1 more source