Results 281 to 290 of about 1,424,575 (357)

Modified Bis-pyrimidine Clamps for Triplex Formation and Their Use in SARS-CoV‑2 Detection. [PDF]

ACS Omega
Domínguez A, Gargallo R, Cuestas-Ayllón C, Gomez-Pinto I, Fàbrega C, de la Fuente JM, Damha MJ, González C, Eritja R, Aviñó A.   +9 more
europepmc   +1 more source

Engineering DNA Origami Captors for TGFβ1 Sequestration to Enhance Tumor Immune Modulation and Therapy

Advanced Science, EarlyView.
Programmable DNA framework captors effectively deplete circulatingtransforming growth factor‐β1 (TGFβ1) through fast systemic clearance and reshape the tumor immune microenvironment, alleviating immunosuppression to inhibit tumor progression. Abstract Efficient modulation of pivotal immune‐regulatory molecules to leverage the tumor microenvironment ...
Xiao Chen, Dunfang Liu, Jiahui Jin, Han Yao, Yao Sheng, Yarong Liu, Jingwei Sun, Yang Yang   +7 more
wiley   +1 more source

Rescue of the Stargardt Disease Phenotype in <i>Abca4</i> Knockout Mice Through Dietary Modulation of the Vitamin A Receptor RBPR2. [PDF]

FASEB Bioadv
Radhakrishnan R, Leung M, Yochim D, Roehrich H, McPherson SW, Lobo GP.   +5 more
europepmc   +1 more source

Engineered crRNA Drives RPA‐T7‐CRISPR/Cas14a Cascade for Ultrasensitive Detection of ctDNA PIK3CA H1047R

Advanced Science, EarlyView.
The TIDE‐Cas14a system, an integrated RPA‐T7‐CRISPR/Cas14a cascade platform incorporating engineered crRNA mismatches, enables ultrasensitive detection of the PIK3CA H1047R mutation in breast cancer circulating tumor DNA, with a limit of detection as low as 0.01%, surpassing the sensitivity of droplet digital PCR.
Yuanyuan Yu, Mengru Jin, Weiguang Yuan, Yajie Gong, Siwei Li, Xuquan Qin, Jianxun Hou, Jialin Liu, Siyu Liu, Hui Li, Yijun Chu, Yingjie Wang, Youxue Zhang, Fang Fang, Wenhui Hao, Yuling Gu, Qinchen Fan, Jing Lin, Da Pang, Xianyu Zhang   +19 more
wiley   +1 more source

The impact of biotic and abiotic interactions on Candidatus Kouleothrix bulking in a full-scale activated sludge anaerobic-anoxic-oxic plant in Japan. [PDF]

Sci Rep
Nittami T, Ishizuka N, Sakurai Y, Seviour RJ.   +3 more
europepmc   +1 more source

Precision‐Arranged DNA Origami Plasmonic Nanoantennas for Multidimensional Smart‐Warning of Weightlessness Induced Bone Loss

Advanced Science, EarlyView.
It is synthesized precision‐arranged DNA origami plasmonic nanoantennas for multiplexed and intelligent warning of bone loss induced by microgravity and radiation. The ordered nanoantennas simultaneously and accurately detected calcium ions, interleukin‐6, and microRNA‐214 in serum from mice exposed to microgravity and radiation, with performance ...
Yufan Ling, Xuan Qin, Weijia Sun, Fan Yue, Yiwei Wang, Di Fan, Haoyuan Xu, Ruao Xie, Jiawei Zhang, Jianwei Li, Bingyan Li, Yang Yang, Yingxian Li, Houyu Wang, Guangming Zhou   +14 more
wiley   +1 more source

Engineered Fusion Enzyme‐Mediated Non‐Consecutive Cyclization‐Glycosylation Enables Heterologous Synthesis of Antifungal Enfumafungin

Advanced Science, EarlyView.
The artificial biosynthetic pathway potentially involved in biosynthesis of enfumafungin is first reconstructed in an optimized Aspergillus oryzae chassis with the increased site‐specific integration efficiency and shortened time for marker recycling, which requires an artificial fusion enzyme EfuA(TC)FsoA(GT).
Yaohui Gao, Jianming Lv, Yue Zhong, Zhiqin Cao, Rui Luo, Yue Qi, Gaoqian Wang, Shaoyang Li, Guodong Chen, Dan Hu, Hao Gao, Xinsheng Yao   +11 more
wiley   +1 more source

Loss of Hepatic Angiotensinogen Attenuates Diastolic Dysfunction in Heart Failure with Preserved Ejection Fraction

Advanced Science, EarlyView.
Increased hepatic angiotensinogen (AGT) abundance leads to cardiac diastolic dysfunction via the AngII‐independent pathway. Liver‐derived AGT is internalized by LRP2 in cardiac endothelial cells, subsequently contributing to myocardial diastolic dysfunction by suppressing microvascular angiogenesis via inhibiting the GATA2/Pim3 pathway.
Zetao Heng, Min Hong, Zhaocai Zhang, Ximing Ye, Jianan Zhou, Wentao Wu, Jiabing Rong, Yinchuan Xu   +7 more
wiley   +1 more source

New Approach to Assembling Nucleic Acid Dendrons on a Solid Phase. [PDF]

Org Lett
Chik GJ, El-Sagheer AH, Brown T.
europepmc   +1 more source

Studies upon Fluorescent Modulation of Silver Nanoclusters Formed on Bifunctional DNA Template. [PDF]

Int J Mol Sci
Filipczuk P, Fedoruk-Wyszomirska A, Nowak-Karnowska J, Pietralik-Molińska Z, Banachowicz E, Kozak M, Dembska A.   +6 more
europepmc   +1 more source