Results 141 to 150 of about 113,580 (306)
Noncoding RNAs in Host–Microbiota Interaction
Animal Research and One Health, EarlyView.The intricate interplay between gut microbiota and the host exerts a profound impact on host biological processes and disease development. This review highlights the pivotal role of noncoding RNAs (ncRNAs) in this interaction. Host ncRNAs regulate gene expression and microbiota composition, whereas microbial small RNAs (sRNAs) modulate host gene ...
Ziyi Zhao +7 more
wiley +1 more source
Long-Tail Feature of DNA Words Over- and Under-Representation in Coding Sequences [PDF]
Computational Methods in Science and Technology 6, 65-71 (2000), 2001 We have analyzed DNA sequences of known genes from 16 yeast chromosomes (Saccharomyces cerevisiae) in terms of oligonucleotides. We have noticed that the relative abundances of oligonucleotide usage in the genome follow a long-tail Levy-like distribution.
arxiv
Aptamers in oncology: a diagnostic perspective [PDF]
, 2008 Nucleic acid sequences can produce a wide variety of three-dimensional conformations. Some of these structural forms are able to interact with proteins and small molecules with high affinity and specificity.
Khan, Huma, Missailidis, Sotiris
core
X‐ray controlled release strategy in cancer therapy
BMEMat, EarlyView.A comprehensive review on the design principles and current strategies of X‐ray stimulated release systems in cancer therapy, focusing on the X‐ray responsive functional groups and materials as well as discussing the advantages and current challenges of X‐ray controlled release systems in cancer therapy.
Yiling Ruan +5 more
wiley +1 more source
A new formalism for calculation of the partition function of single stranded nucleic acids [PDF]
arXiv, 2005 A new formalism for calculation of the partition function of single stranded nucleic acids is presented. Secondary structures and the topology of structure elements are the level of resolution that is used. The folding model deals with matches, mismatches, symmetric and asymmetric interior loops, stacked pairs in loop and dangling end regions, multi ...
arxiv
Catheterization and Cardiovascular Interventions, EarlyView.ABSTRACT Background Lipoprotein(a) [Lp(a)] is associated with increased cardiovascular risk, but its influence on plaque characteristics at optical coherence tomography (OCT) evaluation is not fully understood. Aims This study seeks to explore the impact of Lp(a) levels on plaque morphology as assessed by OCT in a very high‐risk subset of patients ...
Francesca Maria Di Muro +13 more
wiley +1 more source
Hybridization to surface-bound oligonucleotide probes: Influence of point defects [PDF]
arXiv, 2006 Microarray-based genotyping is based on the high discrimination capability of oligonucleotide probes. For detection of Single Nucleotide Polymorphisms (SNPs) single-base discrimination is required. We investigate how various point-mutations, comprising single base mismatches (MMs), insertions and deletions, affect hybridization of DNA-DNA ...
arxiv
Hallmarks of Neuroblastoma—Pathophysiology, Diagnosis, and Therapeutic Interventions
Cancer Nexus, EarlyView.ABSTRACT Neuroblastoma, the most common extracranial solid tumor in childhood, continues to challenge clinicians and researchers because of its heterogeneous nature and complex pathophysiology. Recent breakthroughs in molecular profiling revealed intricate genetic alterations driving tumor progression, necessitating an updated perspective on the ...
Abhimanyu Thakur, Anne Dijkstra
wiley +1 more source
Molecular Therapy: Nucleic Acids, 2023 Trigger-activatable antisense oligonucleotides have been widely applied to regulate gene function. Among them, caged cyclic antisense oligonucleotides (cASOs) maintain a specific topology that temporarily inhibits their interaction with target genes.
Zhongyu Wang +6 more
doaj
Power-law Signatures and Patchiness in Genechip Oligonucleotide Microarrays [PDF]
arXiv, 2007 . Genechip oligonucleotide microarrays have been used widely for transcriptional profiling of a large number of genes in a given paradigm. Gene expression estimation precedes biological inference and is given as a complex combination of atomic entities on the array called probes.
arxiv