Results 61 to 70 of about 72,368 (158)

Integrin Targeted Delivery of Gene Therapeutics

Theranostics, 2011
Integrins have become key targets for molecular imaging and for selective delivery of anti-cancer agents. Here we review recent work concerning the targeted delivery of antisense and siRNA oligonucleotides via integrins. A variety of approaches have been
Rudy L Juliano, Xin Ming, Osamu Nakagawa, Rongzuo Xu, Hoon Yoo
doaj  

Antisense oligonucleotides targeting IRF4 alleviate psoriasis

Acta Pharmaceutica Sinica B
Interferon regulatory factor 4 (IRF4) is a critical transcription factor that governs the differentiation of cluster of differentiation 4+ (CD4+) T cells.
Yanxia Yu, Yirui Wang, Weiwei Chen, Chang Zhang, Zhuo li, Jing Yu, Minhao Wang, Can Song, Sihao Yan, Jiayi Lu, Liangdan Sun   +10 more
doaj   +1 more source

Ultrasmall nanoparticles for co-delivery of antisense oligonucleotides targeting miR-21 and miR-210 to treat glioblastoma

Journal of Nanobiotechnology
Glioblastoma (GBM) is the most common and aggressive type of brain tumour, with less than 5% of patients surviving more than 5 years. Despite decades of research to understand the underlying pathophysiological causes, it has witnessed very slow progress ...
Ravi Raj Singh, Ritu Kulshreshtha, Amirali Popat   +2 more
doaj   +1 more source

Design of antisense oligonucleotides

Folia Pharmacologica Japonica, 2016
Satoshi, Obika, Yuuya, Kasahara
openaire   +3 more sources

RNA duplex formation and competing endogenous RNA, proposed as mechanisms in regulating expression of natural antisense transcripts- from hypotheses to potential therapeutic applications. [PDF]

Front Mol Biosci
Nakatake R, Okuyama T, Kimura T, Nishizawa M.   +3 more
europepmc   +1 more source

Antisense RNA controls the degradation of phycobilisomes in heterocyst-forming cyanobacteria by a transcriptional interference mechanism. [PDF]

Nucleic Acids Res
Álvarez-Escribano I, Brenes-Álvarez M, Georg J, Vioque A, Muro-Pastor AM.   +4 more
europepmc   +1 more source

Transient Cyclic Structured Oligonucleotide Designs for Therapeutic Applications. [PDF]

Curr Protoc
Agrawal S.
europepmc   +1 more source

Delivery and uptake of free and liposome-encapsulated cholesterol-conjugated antisense oligonucleotides in Atlantic salmon sperm: insights from high-resolution imaging. [PDF]

BMC Vet Res
Swain JK, Wolfson DL, Swain T, Flaten GE, Škalko-Basnet N, Ahluwalia BS, Tveiten H.   +6 more
europepmc   +1 more source

Investigating the <i>In Vivo</i> Performance of Tannic Acid-Modified siRNA in the Heart and Liver. [PDF]

Bioconjug Chem
Hayes OG, Rädler J, Filipiak E, Czapik T, Huang Y, Ojansivu M, Saher O, Bood M, Zain R, El Andaloussi S, Honcharenko M.   +10 more
europepmc   +1 more source

FACS-based dual fluorescence reporter assay demonstrates efficacy of antisense oligonucleotide therapy of novel <i>PRPF3</i> intronic splice variant. [PDF]

Mol Ther Nucleic Acids
Dolgin V, Eremenko E, Narkis G, Mazor-Oring M, Gradstein L, Birk OS.   +5 more
europepmc   +1 more source