Results 161 to 170 of about 312,210 (300)

Optimization of SWCNT‐FET Biosensors by Aptamer Engineering and Toehold‐Mediated Strand Displacement

Advanced Science, EarlyView.
Aptamer‐based single‐walled carbon nanotube (SWCNT) field‐effect transistor (FET) biosensors are developed for label‐free, real‐time biomarker detection. Truncated DNA aptamers enhance sensitivity through improved conformational switching. A toehold‐mediated strand displacement (TMSD) strategy optimizes functionalization and simplifies fabrication. The
Haosen Miao, Tingting Zheng, Houlin Yu, Gririraj Manoharan, Gustavo Sant'Anna, Nicholas Bedfrod, Jorge L. Chávez, Chang‐Seuk Lee, Matteo Palma   +8 more
wiley   +1 more source

Editorial: Recent advancements in RNA-based and targeted therapeutics

Frontiers in Genetics
Yiming Meng, Viola Bianca Serio, Viola Bianca Serio, Yuquan Tong, Tao Huang, Elisa Frullanti, Elisa Frullanti, Maria Palmieri, Maria Palmieri   +8 more
doaj   +1 more source

OnApplying String Matching in Searching Unique

, 2008
In this paper we consider using string matching in finding unique, gene specific oligonucleotides, which can be used for example in genomic research involving polymerase chain reaction, gene cloning, microarray technology or antisense DNA studies ...
Oligonucleotides Heikki Hyyr, Heikki Hyyrö   +1 more
core  

A ligase-based toolbox for research and diagnostics in molecular medicine. [PDF]

Nucleic Acids Res
Landegren U.
europepmc   +1 more source

A Dual‐Channel Synergistic Ultrasensitive Biosensor for Tumor Liquid Biopsy

Advanced Science, EarlyView.
ABSTRACT Liquid biopsy technology, which detects circulating tumor DNA (ctDNA) in cerebrospinal fluid, plays a crucial role in the early diagnosis and precision treatment of gliomas. However, the intrinsically low abundance and rapid clearance of ctDNA pose substantial challenges for conventional analytical techniques, such as droplet digital PCR and ...
Yu Sun, Jing Zhang, Chenqing Liu, Jing Lou, Sihui Wang, Xiangtian Ji, Xiaofang Zhao, Shirui Xu, Jingyu Feng, Bin Liu, Chao Chang, Qinggang Ge, Jun Yang   +12 more
wiley   +1 more source

OligoN-Design: A Simple and Versatile Tool to Design Specific Probes and Primers From Large Heterogeneous Datasets. [PDF]

Mol Ecol Resour
Sandin MM, Walde M, Henry N, Forn I, Simon N, Berney C, Massana R, Richter DJ.   +7 more
europepmc   +1 more source

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

Chemically synthesized high-fidelity oligos ≤ 600 nt as building blocks to accelerate complex gene construction in synthetic biology. [PDF]

Synth Biol (Oxf)
Zhang M, Hu Y, Huang H, Shi Y.
europepmc   +1 more source

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

Advanced Science, EarlyView.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao, Xiaoyu Li, Hongwei Wang, Zongyi Li, Qun Wang, Yangyang Zhang, Xu Jing, Xia Qi, Qingjun Zhou, Shengqian Dou, Lixin Xie   +10 more
wiley   +1 more source

Modular RNA:DNA Nanostructures Enable Nanopore Profiling of rRNA Processing and rRNA Variants. [PDF]

ACS Nano
Boskovic F, Sandler SE, Brauburger S, Shui Y, Kumar B, Dias JP, Naydenova P, Zhu J, Baker S, Keyser UF.   +9 more
europepmc   +1 more source