Results 291 to 300 of about 584,539 (379)

Clinical Potential of Oligonucleotide Therapeutics against Pancreatic Cancer

, 2019
Kazuki Takakura, Atsushi Kawamura, Yuichi Torisu, Shigeo Koido, Naohisa Yahagi, Masayuki Saruta   +5 more
openalex   +2 more sources

Tumor Extracellular Vesicles lncOSLMT Drives Lung Inflammatory Premetastatic Niche Formation in Osteosarcoma via m6A‐Dependent hnRNPA2B1/COX‐2 Axis

Advanced Science, EarlyView.
Tumor‐derived extracellular vesicles program inflammatory lung premetastatic niches through selective delivery of long noncoding RNAs. This work reveals EVs‐associated lncOSLMT as a key driver of lung fibroblast activation via m6A‐dependent PTGS2 stabilization.
Hongbo Li, Zehao Guo, Yutong Zou, Jiongfeng Zhang, Jixiang Shi, Xihong Fu, Jian Tu, Hao Yao, Xuanxuan Lu, Lili Wen, Xianbiao Xie   +10 more
wiley   +1 more source

Differential stability and dynamics of DNA-based and RNA-based coacervates affect non-enzymatic RNA chemistry. [PDF]

Nat Commun
Nakashima KK, Mihoubi FZ, Saraya JS, Russell KO, Rahmatova F, Robinson JD, Maristany MJ, Huertas J, Rubio-Sánchez R, Collepardo-Guevara R, O'Flaherty DK, Bonfio C.   +11 more
europepmc   +1 more source

A Sirtuin‐1‐Targeted Gene‐Activating Tetrahedral DNA Attenuates Bladder Fibrosis by Restoring Mitophagy in Fibroblasts via the SIRT1‐FOXO3‐BNIP3 Axis

Advanced Science, EarlyView.
The SIRT1‐targeted saRNA‐delivering tetrahedral DNA (TSA) treatment effectively upregulates SIRT1 expression, which subsequently promotes FOXO3A deacetylation. This deacetylation event relieves FOXO3A's transcriptional repression on the BNIP3 gene, thereby initiating PINK1‐PARKIN‐dependent mitophagy.
Wei Wang, Ran Yan, Lede Lin, Lei Xiang, Xiaozhi Xia, Liao Peng, Xiaoshuai Gao, Jiawei Chen, Yang Xiong, Liang Zhou, Yunfeng Lin   +10 more
wiley   +1 more source

A modified X10-23 DNAzyme that can better access large, structured RNA targets. [PDF]

Nucleic Acids Res
Nurmi C, Barber HM, Kaur H, Brennan JD, Damha MJ, Li Y.   +5 more
europepmc   +1 more source

Immunoaffinity‐Mimetic Assembly of Peptide‐Aptamer Conjugates and Stem Cell‐Derived Exosomes into Hierarchical Microgels for Spinal Cord Injury Repair

Advanced Science, EarlyView.
Inspired by antibody‐antigen binding, this study develops an unprecedented immunoaffinity‐mimetic assembly strategy, with Peptide‐AptCD63 conjugates acting as antibody surrogates binding CD63 epitopes on mesenchymal stem cell‐derived exosomes. This creates a hierarchical microstructure intended to synergistically integrate antioxidative and anti ...
Dantong Zheng, Yuxin Bai, Zhibo Liu, Zinan Zhao, Yiming Kong, Yao Xu, Qi Jia, Rongrong Zhu, Yong Hu   +8 more
wiley   +1 more source

Posttranscriptional 3'-Terminal Modifications of <i>Escherichia coli</i> RNA Fragments Evolved for Diversity Boosting. [PDF]

Microorganisms
Kamoldinov NM, Panyukov VV, Kolzhetsov NP, Markelova NY, Shavkunov KS, Shvyreva US, Alikina OV, Glazunova OA, Praslova IA, Ozoline ON.   +9 more
europepmc   +1 more source

miR‐135a‐5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao, Haiyun Chen, Yanan Zhu, Zhiping Xia, Hangyuan He, Yutang Liu, Tianshu Yang, Hui Wang, Ying Ao   +8 more
wiley   +1 more source

Aggregation-induced emission of DNA fluorescence as a novel pan-marker of cell death, senescence and sepsis <i>in vitro</i> and <i>in vivo</i>. [PDF]

Theranostics
Hu Y, Wang X, Lu K, Cheang C, Liu Y, Zhu Y, Xie L, Li M, Zhou Q, Yan W, Hou Y, Zhang H, Zheng W, Xu C, Chen X, Shen HM, Huang ZJ, Chen YH, Zhou Y, Cai PL, Zhong H, Liu L, Wu XP, Liu X, Li X, Zeng N, Assaraf YG, Liu TM.   +27 more
europepmc   +1 more source