Results 291 to 300 of about 449,240 (358)

Synthesis of New Polyfluoro Oligonucleotides via Staudinger Reaction. [PDF]

Int J Mol Sci
Klabenkova K, Zakhryamina A, Burakova E, Bizyaev S, Fokina A, Stetsenko D.   +5 more
europepmc   +1 more source

Immunostimulatory DNA Tetrahedron‐Based Nanovaccine Combined With Immune Checkpoint PD‐1 Blockade for Boosting Systemic Immune Responses Against Oral Squamous Cell Carcinoma

Aggregate, EarlyView.
This study introduces an immunomodulatory DNA tetrahedral framework nucleic acid‐based nanovaccine tFNA‐CpG. The functionalized nanovaccine shows stable and well‐defined morphological characteristics and can be efficiently taken up by APCs. When combined with the immune checkpoint inhibitor anti‐PD‐1, it notably ameliorated the immunosuppressive ...
Xueting Yang, Yun Wang, Yan Yang, Sicheng Zhang, Dianri Wang, Yi Luo, Chunyan Shui, Yongcong Cai, Ruoyi Yang, Shuang Dong, Mu Yang, Yunfeng Lin, Chao Li   +12 more
wiley   +1 more source

Nonenzymatic RNA copying with a potentially primordial genetic alphabet. [PDF]

Proc Natl Acad Sci U S A
Fang Z, Jia X, Xing Y, Szostak JW.
europepmc   +1 more source

Lung‐Penetrating Biomimetic Extracellular Vesicle Spherical Nucleic Acids for Pulmonary Fibrosis Therapy Through ROS Scavenging and Anti‐Inflammatory Effects

Aggregate, EarlyView.
This work describes a biomimetic extracellular vesicle‐spherical nucleic acid (BEV‐SNA) platform for idiopathic pulmonary fibrosis (IPF) therapy. BEV‐SNA is composed of mechanically extruded BEVs from primary MSCs and cholesterol‐modified ssDNA that are assembled through hydrophobic interactions.
Saiyun Lou, Jiangpo Ma, Pan Fu, Lin Li, Jingyun Huang, Fangxue Jing, Yuhui Wang, Sihua Qian, Jianping Zheng, Jiang Li, Zhaoxing Dong, Kaizhe Wang   +11 more
wiley   +1 more source

Erratum: <i>In vivo</i> efficacy and safety of systemically administered serinol nucleic acid-modified antisense oligonucleotides in mouse kidney. [PDF]

Mol Ther Nucleic Acids
Tsuboi T, Hattori K, Ishimoto T, Imai K, Doke T, Hagita J, Ariyoshi J, Furuhashi K, Kato N, Ito Y, Kamiya Y, Asanuma H, Maruyama S.   +12 more
europepmc   +1 more source

Inhibition of replication and expression of human T-cell lymphotropic virus type III in cultured cells by exogenous synthetic oligonucleotides complementary to viral RNA.

, 1986
Paul C. Zamecnik, John Goodchild, Y‐h. Taguchi, Prem S. Sarin   +3 more
openalex   +1 more source

A Case of Prader‐Willi Syndrome With a Deletion Including MAGEL2, NDN, and MKRN3, but Excluding SNRPN and SNORD116

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Prader‐Willi syndrome (PWS) is a neurodevelopmental disorder typically caused by large deletions or imprinting defects on chromosome 15q11.2, encompassing multiple genes. While the contribution of individual genes to the PWS phenotype remains unclear, previous studies suggested that isolated deletions of MAGEL2, NDN, and MKRN3, excluding the ...
Jannis Buecking, Yu An, Weimin Bi, Katrin Hinderhofer, Susanne Theiß, Anne Slavotinek, Christian P. Schaaf   +6 more
wiley   +1 more source

Ion-DNA Interactions as a Key Determinant of Uracil DNA Glycosylase Activity. [PDF]

Biochemistry
Greenwood SN, Dispensa AN, Wang M, Bauer JR, Vaden TD, Liu Z, Weiser BP.   +6 more
europepmc   +1 more source

Tall Stature and Scoliosis Associated With a Novel Homozygous Loss‐of‐Function Missense Variant in NPR3

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT NPR3‐related tall stature is characterized by tall stature, elongated big toes, and additional epiphyses in hand and foot bones. The condition is caused by biallelic loss‐of‐function variants affecting natriuretic peptide receptor 3 (NPR3). Five individuals from four different families have been reported.
Pierre Moffatt, Chantal Janelle, Valancy Miranda, Ghalib Bardai, Frank Rauch   +4 more
wiley   +1 more source

Impacts of sequence and structure on pyrrolocytosine fluorescence in RNA. [PDF]

Nucleic Acids Res
Coulson TL, Widom JR.
europepmc   +1 more source