Results 301 to 310 of about 414,656 (346)
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Mass spectrometry reviews (Print), 2019
Oligonucleotides are an emerging class of drugs that are manufactured by solid-phase synthesis. As a chemical class, they have unique product-related impurities and degradants, characterization of which is an essential step in drug development.
Soheil Pourshahian
semanticscholar +1 more source
Oligonucleotides are an emerging class of drugs that are manufactured by solid-phase synthesis. As a chemical class, they have unique product-related impurities and degradants, characterization of which is an essential step in drug development.
Soheil Pourshahian
semanticscholar +1 more source
Circular Oligonucleotides: New Concepts in Oligonucleotide Design
Annual Review of Biophysics and Biomolecular Structure, 1996Recent progress in the synthesis and properties of circular oligonucleotides as ligands for DNA and RNA and as templates for polymerase enzymes is described. Small synthetic circular DNAs, RNAs, and chimeric analogues ranging from 28 to 74 nucleotides in size have been synthesized with the use of a nonenzymatic ligation strategy.
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Expert Opinion on Drug Discovery, 2008
Numerous oligonucleotide-based biopharmaceuticals have been tested to suppress disease progression. These potent therapeutics include plasmids containing transgenes, antisense oligonucleotides, ribozymes, DNAzymes, decoys, aptamers and small interfering RNAs.
Yoshitaka, Isaka +3 more
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Numerous oligonucleotide-based biopharmaceuticals have been tested to suppress disease progression. These potent therapeutics include plasmids containing transgenes, antisense oligonucleotides, ribozymes, DNAzymes, decoys, aptamers and small interfering RNAs.
Yoshitaka, Isaka +3 more
openaire +2 more sources
Synthesis of Oligonucleotide—Peptide and Oligonucleotide—Protein Conjugates
ChemInform, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
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Labeling of Oligonucleotides with Fluorescein
Molecular Biotechnology, 1997The labeling of oligonucleotide probes using a fluorescein-labeled nucleotide is described. The reaction is characterized by careful control of the nucleotide and probe molar ratio in order to produce a tail that gives good detection sensitivity without compromising hybridization stringency control of the probe sequence.
Patricia M. E. Chadwick, Ian Durrant
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2017
Oligonucleotides (ONs), the focus of the chapter herein, are mostly known for their utility to selectively manipulate RNA processing by increasing or decreasing target gene levels, in particular by inducing enzymatic RNA degradation, blocking or mimicking miRNAs, inhibiting mRNA translation or modulating pre-mRNA splicing.
Covello, Giuseppina +1 more
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Oligonucleotides (ONs), the focus of the chapter herein, are mostly known for their utility to selectively manipulate RNA processing by increasing or decreasing target gene levels, in particular by inducing enzymatic RNA degradation, blocking or mimicking miRNAs, inhibiting mRNA translation or modulating pre-mRNA splicing.
Covello, Giuseppina +1 more
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Freezing-directed Stretching and Alignment of DNA Oligonucleotides.
Angewandte Chemie, 2019Most single-stranded DNA oligonucleotides are random coils with a persistence length of below 1 nm. So far, no good methods are available to stretch oligonucleotides.
Biwu Liu +4 more
semanticscholar +1 more source
Therapeutic Applications Of Oligonucleotides
Annual Review of Pharmacology and Toxicology, 1992This review focuses strictly on the pharmacodynamic considerations of the use of oligonucleotides designed to interact with nucleic acids as therapeutics. The objectives are to place oligonucleotide therapeutics in the context of modern drug discovery and development and to summarize recent progress.
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Chemical Communications, 2020
Oligonucleotides containing dU, which are called booster oligonucleotides, are excised by uracil-DNA glycosylase in the nucleus and efficiently release complementary strands.
Lei Wang +3 more
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Oligonucleotides containing dU, which are called booster oligonucleotides, are excised by uracil-DNA glycosylase in the nucleus and efficiently release complementary strands.
Lei Wang +3 more
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Polyethylenimine-based formulations for delivery of oligonucleotides.
Current Medicinal Chemistry, 2019Polyethylenimine (PEI) is well-known as the non-viral gene delivery vector, especially for the oligonucleotides delivery. However, its clinical applications are significantly limited due to its high cationic charge, low cell recognition, and interaction ...
Fei Hao +8 more
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