Results 311 to 320 of about 449,240 (358)

Extracellular Vesicles in Calcium Oxalate Nephrolithiasis: Emerging Biomarkers and Therapeutic Potential

Advanced NanoBiomed Research, EarlyView.
Kidney stones cause significant pain and healthcare costs. Current prediction, diagnosis, and treatment options are limited. Extracellular vesicles (EVs), rich in proteins, lipids, and nucleic acids, offer a promising solution. This review explores the roles of EVs in kidney stone management, highlighting their potential as biomarkers and therapeutic ...
Wang Zhu, Xu Changzhi, Deng Qiong, Liang Hui   +3 more
wiley   +1 more source

Exploring RNA modifications in infectious non-coding circular RNAs. [PDF]

RNA Biol
Vopalensky P, Škríba A, Chiumenti M, Ďuričeková L, Šimonová A, Lukšan O, Di Serio F, Navarro B, Cahova H.   +8 more
europepmc   +1 more source

Remote Control of Eukaryotic Gene Expression by a Modular Ultrasound‐Responsive RNA Toolkit

Angewandte Chemie, EarlyView.
A modular RNA‐based sonogenetic toolkit enables remote control of gene expression in eukaryotes by releasing small molecule modulators from ultrasound‐responsive carriers. These modulators activate engineered mRNA elements such as riboswitches, leading to tunable protein expression.
Fahimeh Charbgoo, Aman Ishaqat, Junlin Chen, Fabian Wiertz, Adrian Kuzmanović, Matthias Bartneck, Fabian Kiessling, Andreas Herrmann   +7 more
wiley   +1 more source

SNA-modified antisense oligonucleotides: A new pathway for renal targeting? [PDF]

Mol Ther Nucleic Acids
Dumoulin B, Yamada K, Susztak K.
europepmc   +1 more source

Light‐Triggered CRISPR/Cas12a for Genomic Editing and Tumor Regression

Angewandte Chemie, EarlyView.
A photo‐triggered CRISPR/Cas12a machinery for gene editing is introduced. The machinery is applied for endogenous DNA methyltransferase 1 (DNMT1) gene editing and for in vitro disruption of the hepatocyte growth factor (HGF) gene. The machinery is used for in vivo knockout and disruption of the HGF gene in HepG2 tumors, resulting in effective apoptosis
Hong Liu, Jiantong Dong, Renzhi Wu, Jun Dai, Xiaoding Lou, Fan Xia, Itamar Willner, Fujian Huang   +7 more
wiley   +1 more source

Single-molecule detection of oligonucleotides using the fluorescent nucleobase analogue ABN. [PDF]

Chem Sci
Samaan GN, Jimenez Salinas A, Bailie AE, Grim J, Cizmic JM, Jones AC, Lee Y, Purse BW.   +7 more
europepmc   +1 more source

Synthesis of Versatile DNA‐Conjugated Aldehydes by Controlled Oxidation of Amines

Angewandte Chemie, EarlyView.
A controlled oxidation strategy enables efficient in situ generation of aldehyde‐functionalized DNAs from DNA‐conjugated amines using O2/laccase/TEMPO. This approach facilitates reversible amine–aldehyde transformations for DNA bioconjugation, and provides access to chemically diverse DNA‐encoded libraries, broadening the toolbox for chemical biology ...
Guixian Zhao, Mengping Zhu, Pengyang He, Qigui Nie, Yangfeng Li, Gong Zhang, Yizhou Li   +6 more
wiley   +1 more source

Autocatalytic assembly of a chimeric aminoacyl-RNA synthetase ribozyme. [PDF]

Sci Adv
Radakovic A, Todisco M, Mishra A, Szostak JW.   +3 more
europepmc   +1 more source

A Robust Strategy for Introducing Amino-Modifiers in Nucleic Acids: Enabling Novel Amino Tandem Oligonucleotide Synthesis in DNA and RNA. [PDF]

Chemistry
Saraya JS, Horton NG, Sammons SR, O Flaherty DK.   +3 more
europepmc   +1 more source

Assembly of catalytic complexes from randomized oligonucleotides. [PDF]

Sci Adv
Han X, Müller UF.
europepmc   +1 more source