Results 331 to 340 of about 584,539 (379)
Some of the next articles are maybe not open access.
2017
Oligonucleotides (ONs), the focus of the chapter herein, are mostly known for their utility to selectively manipulate RNA processing by increasing or decreasing target gene levels, in particular by inducing enzymatic RNA degradation, blocking or mimicking miRNAs, inhibiting mRNA translation or modulating pre-mRNA splicing.
Covello, Giuseppina +1 more
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Oligonucleotides (ONs), the focus of the chapter herein, are mostly known for their utility to selectively manipulate RNA processing by increasing or decreasing target gene levels, in particular by inducing enzymatic RNA degradation, blocking or mimicking miRNAs, inhibiting mRNA translation or modulating pre-mRNA splicing.
Covello, Giuseppina +1 more
openaire +2 more sources
Immunostimulatory Oligonucleotides
Recent Patents on Inflammation & Allergy Drug Discovery, 2011RNA-protein interactions have been characterized often. Above all, the proteins which are associated with the studied RNA should be precisely identified. The pharmaceutical compositions containing nucleic acids and/or other compounds can be administered by any suitable route for administering medications. The immunostimulatory oligonucleotides play the
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Trends in Biotechnology, 1992
Recent studies have focused on the ability of oligonucleotides to affect the genetic processes of many organisms, including viruses. Hence, oligonucleotides may represent a future source of biotechnologically derived compounds of therapeutic importance for diseases such as cancer and AIDS.
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Recent studies have focused on the ability of oligonucleotides to affect the genetic processes of many organisms, including viruses. Hence, oligonucleotides may represent a future source of biotechnologically derived compounds of therapeutic importance for diseases such as cancer and AIDS.
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Current Opinion in Biotechnology, 1992
Rapid progress in oligonucleotide therapeutics has continued over the past year as major programs established in the past four years have grown and begun to be productive. Important advances were reported in the medicinal chemistry of oligonucleotides and in understanding their pharmacodynamic properties.
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Rapid progress in oligonucleotide therapeutics has continued over the past year as major programs established in the past four years have grown and begun to be productive. Important advances were reported in the medicinal chemistry of oligonucleotides and in understanding their pharmacodynamic properties.
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Mass spectrometry reviews (Print), 2019
Oligonucleotides are an emerging class of drugs that are manufactured by solid-phase synthesis. As a chemical class, they have unique product-related impurities and degradants, characterization of which is an essential step in drug development.
Soheil Pourshahian
semanticscholar +1 more source
Oligonucleotides are an emerging class of drugs that are manufactured by solid-phase synthesis. As a chemical class, they have unique product-related impurities and degradants, characterization of which is an essential step in drug development.
Soheil Pourshahian
semanticscholar +1 more source
Circular Oligonucleotides: New Concepts in Oligonucleotide Design
Annual Review of Biophysics and Biomolecular Structure, 1996Recent progress in the synthesis and properties of circular oligonucleotides as ligands for DNA and RNA and as templates for polymerase enzymes is described. Small synthetic circular DNAs, RNAs, and chimeric analogues ranging from 28 to 74 nucleotides in size have been synthesized with the use of a nonenzymatic ligation strategy.
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Freezing-directed Stretching and Alignment of DNA Oligonucleotides.
Angewandte Chemie, 2019Most single-stranded DNA oligonucleotides are random coils with a persistence length of below 1 nm. So far, no good methods are available to stretch oligonucleotides.
Biwu Liu +4 more
semanticscholar +1 more source
2011
A brief historical introduction describes early attempts to silence specific genes using the antisense oligonucleotides that flourished in the 1980s. Early aspirations for therapeutic applications were almost extinguished by the unexpected complexity of oligonucleotide pharmacology.
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A brief historical introduction describes early attempts to silence specific genes using the antisense oligonucleotides that flourished in the 1980s. Early aspirations for therapeutic applications were almost extinguished by the unexpected complexity of oligonucleotide pharmacology.
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Polyethylenimine-based formulations for delivery of oligonucleotides.
Current Medicinal Chemistry, 2019Polyethylenimine (PEI) is well-known as the non-viral gene delivery vector, especially for the oligonucleotides delivery. However, its clinical applications are significantly limited due to its high cationic charge, low cell recognition, and interaction ...
Fei Hao +8 more
semanticscholar +1 more source
1993
Abstract 10.1 Single-crystal X-ray structure determination of oligonucleotides containing four or more bases Tables 10.1-10.5 list the principal references to structure determinations published between 1979 and mid-1989. There are three main families of double-helical oligonucleotide structures.
Olga Kennard +2 more
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Abstract 10.1 Single-crystal X-ray structure determination of oligonucleotides containing four or more bases Tables 10.1-10.5 list the principal references to structure determinations published between 1979 and mid-1989. There are three main families of double-helical oligonucleotide structures.
Olga Kennard +2 more
openaire +1 more source