Results 331 to 340 of about 449,240 (358)
Some of the next articles are maybe not open access.
Nephron Experimental Nephrology, 1998
Antisense technology was developed to inhibit gene expression by utilizing an oligonucleotide complementary to the mRNA which encodes the target gene. There are a few possible mechanisms for the inhibitory effects of antisense oligonucleotides. Among them, degradation of mRNA by RNase H is considered to be the major mechanism of action for antisense ...
N, Kashihara, Y, Maeshima, H, Makino
openaire +2 more sources
Antisense technology was developed to inhibit gene expression by utilizing an oligonucleotide complementary to the mRNA which encodes the target gene. There are a few possible mechanisms for the inhibitory effects of antisense oligonucleotides. Among them, degradation of mRNA by RNase H is considered to be the major mechanism of action for antisense ...
N, Kashihara, Y, Maeshima, H, Makino
openaire +2 more sources
Synthesis of Oligonucleotide—Peptide and Oligonucleotide—Protein Conjugates
ChemInform, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire +4 more sources
Expert Opinion on Drug Discovery, 2008
Numerous oligonucleotide-based biopharmaceuticals have been tested to suppress disease progression. These potent therapeutics include plasmids containing transgenes, antisense oligonucleotides, ribozymes, DNAzymes, decoys, aptamers and small interfering RNAs.
Yoshitaka, Isaka +3 more
openaire +2 more sources
Numerous oligonucleotide-based biopharmaceuticals have been tested to suppress disease progression. These potent therapeutics include plasmids containing transgenes, antisense oligonucleotides, ribozymes, DNAzymes, decoys, aptamers and small interfering RNAs.
Yoshitaka, Isaka +3 more
openaire +2 more sources
2017
Oligonucleotides (ONs), the focus of the chapter herein, are mostly known for their utility to selectively manipulate RNA processing by increasing or decreasing target gene levels, in particular by inducing enzymatic RNA degradation, blocking or mimicking miRNAs, inhibiting mRNA translation or modulating pre-mRNA splicing.
Covello, Giuseppina +1 more
openaire +2 more sources
Oligonucleotides (ONs), the focus of the chapter herein, are mostly known for their utility to selectively manipulate RNA processing by increasing or decreasing target gene levels, in particular by inducing enzymatic RNA degradation, blocking or mimicking miRNAs, inhibiting mRNA translation or modulating pre-mRNA splicing.
Covello, Giuseppina +1 more
openaire +2 more sources
Therapeutic Applications Of Oligonucleotides
Annual Review of Pharmacology and Toxicology, 1992This review focuses strictly on the pharmacodynamic considerations of the use of oligonucleotides designed to interact with nucleic acids as therapeutics. The objectives are to place oligonucleotide therapeutics in the context of modern drug discovery and development and to summarize recent progress.
openaire +4 more sources
Chemical Communications, 2020
Oligonucleotides containing dU, which are called booster oligonucleotides, are excised by uracil-DNA glycosylase in the nucleus and efficiently release complementary strands.
Lei Wang +3 more
openaire +3 more sources
Oligonucleotides containing dU, which are called booster oligonucleotides, are excised by uracil-DNA glycosylase in the nucleus and efficiently release complementary strands.
Lei Wang +3 more
openaire +3 more sources
ChemInform, 1993
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A. Suska +6 more
openaire +3 more sources
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A. Suska +6 more
openaire +3 more sources
Combinational synthesis of oligonucleotides and assembly fabrication of oligonucleotide array [PDF]
Colloids and Surfaces B: Biointerfaces, 2005 In this paper, a simple, reliable and flexible method, which integrated in situ synthesis with the spotting technique, was reported to fabricate oligonucleotide array. Different oligonucleotide sequences are synthesized on their relative code glass slides through combinational chemistry, thus the slides are broken into smaller pieces, in which the same
Huishi Guo +4 more
openaire +2 more sources
Synthesis of Oligonucleotides and Oligonucleotide Analogues
1989The aim of this review is to outline modern methods for synthesizing natural oligodeoxynucleotides and certain analogues that may be inhibitors of gene expression. As a consequence, several DNA chemical synthesis methodologies such as the phosphate diester and phosphate triester approaches, which are now primarily only of historical interest, will not ...
openaire +2 more sources
Immunostimulatory Oligonucleotides
Recent Patents on Inflammation & Allergy Drug Discovery, 2011RNA-protein interactions have been characterized often. Above all, the proteins which are associated with the studied RNA should be precisely identified. The pharmaceutical compositions containing nucleic acids and/or other compounds can be administered by any suitable route for administering medications. The immunostimulatory oligonucleotides play the
openaire +2 more sources