Results 341 to 350 of about 449,240 (358)
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2003
Publisher Summary Oligonucleotides (oligos) are synthetic, short, ssDNA molecules used as probes, primers, or as the building blocks for longer DNA strands. The most popular type of chemistry for making oligonucleotides uses the phosphoramidite method, in which building of the nt chain starts on a column carrying the first 3' base.
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Publisher Summary Oligonucleotides (oligos) are synthetic, short, ssDNA molecules used as probes, primers, or as the building blocks for longer DNA strands. The most popular type of chemistry for making oligonucleotides uses the phosphoramidite method, in which building of the nt chain starts on a column carrying the first 3' base.
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Trends in Biotechnology, 1992
Recent studies have focused on the ability of oligonucleotides to affect the genetic processes of many organisms, including viruses. Hence, oligonucleotides may represent a future source of biotechnologically derived compounds of therapeutic importance for diseases such as cancer and AIDS.
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Recent studies have focused on the ability of oligonucleotides to affect the genetic processes of many organisms, including viruses. Hence, oligonucleotides may represent a future source of biotechnologically derived compounds of therapeutic importance for diseases such as cancer and AIDS.
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Titanocene binding to oligonucleotides
Journal of Inorganic Biochemistry, 2018The binding of titanocene to DNA and RNA was examined by means of electrospray mass spectrometry. Titanocene served as a model for its therapeutically active derivatives. The binding preferences were probed by competition experiments with oligonucleotides of varying nucleobase compositions and sequences.
Stefan Schürch, Rahel Patricia Eberle
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Current Opinion in Biotechnology, 1992
Rapid progress in oligonucleotide therapeutics has continued over the past year as major programs established in the past four years have grown and begun to be productive. Important advances were reported in the medicinal chemistry of oligonucleotides and in understanding their pharmacodynamic properties.
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Rapid progress in oligonucleotide therapeutics has continued over the past year as major programs established in the past four years have grown and begun to be productive. Important advances were reported in the medicinal chemistry of oligonucleotides and in understanding their pharmacodynamic properties.
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Oligonucleotide Microarrays: Immobilization of Phosphorylated Oligonucleotides on Epoxylated Surface
Bioconjugate Chemistry, 2006A facile and efficient method for direct immobilization of phosphorylated oligonucleotides on an epoxy-activated glass surface is described. The new immobilization strategy has been analyzed for its performance in DNA microarray under both microwave and thermal conditions.
Pradeep Kumar, Mahajan Sk, K.C. Gupta
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2011
A brief historical introduction describes early attempts to silence specific genes using the antisense oligonucleotides that flourished in the 1980s. Early aspirations for therapeutic applications were almost extinguished by the unexpected complexity of oligonucleotide pharmacology.
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A brief historical introduction describes early attempts to silence specific genes using the antisense oligonucleotides that flourished in the 1980s. Early aspirations for therapeutic applications were almost extinguished by the unexpected complexity of oligonucleotide pharmacology.
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Bromodeoxyuridine-Labeled Oligonucleotides as Tools for Oligonucleotide Uptake Studies
Antisense and Nucleic Acid Drug Development, 2002The mechanisms by which various oligonucleotides (ODNs) and their analogs enter cells are not fully understood. A common technique used in studies on cellular uptake of ODNs is their conjugation with fluorochromes. However, fluorescently labeled ODNs may vary from the parent compounds in charge and hydrophilicity, and they may interact differently with
Anna Kobylanska +3 more
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Pharmacokinetics of oligonucleotides.
Ciba Foundation symposium, 1997The effectiveness of antisense oligonucleotides as therapeutic agents depends on their pharmacokinetics, tissue disposition, stability, elimination and safety profile. Pharmacokinetic data allow one to determine the frequency of administration and any potential toxicity associated with chronic administration.
Sudhir Agrawal, Ruiwen Zhang
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Chromatography of oligonucleotides
Archives of Biochemistry and Biophysics, 1959Herbert A. Sober +2 more
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