Results 341 to 350 of about 584,539 (379)
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Boron Containing Oligonucleotides
Nucleosides, Nucleotides and Nucleic Acids, 1998Abstract Synthesis, physicochemical and biological properties of novel class of oligonucleotide analogues, bearing boron modifications are described. Dedicated to the memory of Professor Tsuijaki Hata.
R F, Schinazi, Z J, Lesnikowski
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Synthesis of Oligonucleotide—Peptide and Oligonucleotide—Protein Conjugates
ChemInform, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
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Carbohydrate‐Oligonucleotide Conjugates
Current Protocols in Nucleic Acid Chemistry, 2009AbstractThis unit describes a strategy for attaching two mannose and two galactose residues to an oligonucleotide. This conjugation can be performed at the 5′‐end of the oligonucleotide sequence, using modified phosphoramidites. First, the oligonucleotide scaffold is synthesized on solid support using a DNA synthesizer, with commercially available and ...
Gwladys, Pourceau +3 more
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Trichloroacetaldehyde modified oligonucleotides
Bioorganic & Medicinal Chemistry Letters, 2005Some commercial batches of dichloroacetic acid (DCA) contain traces of chloral (trichloroacetaldehyde). Using such DCA to effect detritylation during solid-phase oligonucleotide synthesis results in the formation of a family of process impurities in which the atoms of chloral (Cl3CCHO) are incorporated between the 5'-oxygen and phosphorus atoms of an ...
Hans, Gaus +7 more
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Targeting Therapeutic Oligonucleotides
New England Journal of Medicine, 2017Two recent studies test whether oligonucleotide drugs that are tailored to target different cell types — the hepatocyte and the myocyte and cardiomyocyte — actually target those cell types.
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Antisense oligonucleotides: the next frontier for treatment of neurological disorders
Nature Reviews Neurology, 2018C. Rinaldi, M. Wood
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CpG Oligonucleotides as Vaccine Adjuvants.
Methods in molecular biology, 2020Neslihan Kayraklıoğlu +2 more
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Diagnosis with oligonucleotides
Clinics in Dermatology, 1991Abstract Protein-based immunohistochemical techniques like immunoperoxidase methods are now routinely used in many diagnostic dermatopathology laboratories. This is possible because of the availability of antibodies that react with specific, diagnostically useful proteins and because there are simple but sensitive detection systems.
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Precise RNA editing by recruiting endogenous ADARs with antisense oligonucleotides
Nature Biotechnology, 2019Tobias Merkle +8 more
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Cellular uptake and trafficking of antisense oligonucleotides
Nature Biotechnology, 2017S. Crooke +4 more
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