Results 81 to 90 of about 27,967 (201)

Late‐Stage Functionalization of Peptides on the Solid Phase

Angewandte Chemie International Edition, Volume 65, Issue 31, 27 July 2026.
Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source

Epitope mapping of Ebola virus dominant and subdominant glycoprotein epitopes facilitates construction of an epitope-based DNA vaccine able to focus the antibody response in mice

Human Vaccines & Immunotherapeutics, 2017
We performed epitope mapping studies on the major surface glycoprotein (GP) of Ebola virus (EBOV) using Chemically Linked Peptides on Scaffolds (CLIPS), which form linear and potential conformational epitopes.
Daniel A. J. Mitchell, Lesley C. Dupuy, Mariano Sanchez-Lockhart, Gustavo Palacios, Jaap W. Back, Katya Shimanovskaya, Sidhartha Chaudhury, Daniel R. Ripoll, Anders Wallqvist, Connie S. Schmaljohn   +9 more
doaj   +1 more source

The Role of Water in Protein–Ligand Binding: Decisive Factor, Annoying Feature, or Indispensable Control Element: In Any Case, a Major Challenge

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Water influences ligand binding to a protein. Replacing, picking up, or modulating water dynamics restructures the water arrangement and affects the enthalpic and entropic signatures of binding. Whether the two properties add up or cancel each other out determines the expected ligand affinity enhancement.
Gerhard Klebe
wiley   +1 more source

397 Sh-oligopeptide-72 ameliorates the proliferative defects of aging keratinocytes

Journal of Clinical and Translational Science
Objectives/Goals: Aged keratinocytes are less proliferative than adult, and aged skin heals more slowly. We examined the proliferation kinetics of aged and adult human keratinocytes.
Brook Abegaze, Richard Parenteau, Richard Kim, Giselle Vitcov, Victoire Gouirand, Merisa Piper, Ruby Ghadially   +6 more
doaj   +1 more source

Enhanced lymphatic transportation of SLN by mimicking oligopeptide transportation route

Asian Journal of Pharmaceutical Sciences
Solid lipid nanoparticles (SLN) could enhance the oral bioavailability of loaded protein and peptide drugs through lymphatic transport. Natural oligopeptides regulate nearly all vital processes and serve as a nitrogen source for nourishment.
Fuya Jia, Xiaoxing Fan, Licheng Wu, Yating Wang, Jisen Zhang, Zhou Zhou, Lian Li, Jingyuan Wen, Yuan Huang   +8 more
doaj   +1 more source

Potential nutritional strategies to prevent and reverse sarcopenia in aging process: Role of fish oil-derived ω-3 polyunsaturated fatty acids, wheat oligopeptide and their combined intervention

Journal of Advanced Research
Introduction: Nutritional support is potentially considered an essential step to prevent muscle loss and enhance physical function in older adults.
Da Pan, Ligang Yang, Xian Yang, Dengfeng Xu, Shaokang Wang, Han Gao, Hechun Liu, Hui Xia, Chao Yang, Yifei Lu, Jihan Sun, Yuanyuan Wang, Guiju Sun   +12 more
doaj   +1 more source

Enhanced oral drug delivery by mimicking natural amino acid and oligopeptide absorption route

Nano Research
Oral delivery of protein and peptide drugs presents considerable challenges due to their susceptibility to digestive enzymes in gastrointestinal (GI) tract and low efficiency of transepithelial transport.
Ruinan Wu, Xiaoxing Fan, Licheng Wu, Liyun Xing, Jinxia Kong, Zhou Zhou, Jingyuan Wen, Lian Li, Yuan Huang   +8 more
doaj   +1 more source

Biosynthesis of Cyclic Oligopeptide

Cold Spring Harbor Symposia on Quantitative Biology, 1969
K, Kurahashi, M, Yamada, K, Mori, K, Fujikawa, M, Kambe, Y, Imae, E, Sato, H, Takahashi, Y, Sakamoto   +8 more
openaire   +2 more sources

Distribution and biological role of the oligopeptide-binding protein (OppA) in Xanthomonas species

Genetics and Molecular Biology, 2010
In this study we investigated the prevalence of the oppA gene, encoding the oligopeptide binding protein (OppA) of the major bacterial oligopeptide uptake system (Opp), in different species of the genus Xanthomonas.
Elisa E. Oshiro, Milene B. Tavares, Celso F. Suzuki, Daniel C. Pimenta, Claudia B. Angeli, Julio C.F. de Oliveira, Maria I.T. Ferro, Luis C.S. Ferreira, Rita C.C. Ferreira   +8 more
doaj  

Intestinal oligopeptide transport [PDF]

Proceedings of the Nutrition Society, 1995
openaire   +2 more sources