Results 61 to 70 of about 1,458 (206)

Olopatadine attenuates the enhancement of capsaicin-evoked substance P release by bradykinin from cultured dorsal root ganglion neurons [PDF]

, 2006
Olopatadine, a second-generation antihistamine, has recently been suggested to have an inhibitory effect on the tachykinin release from guinea-pig tracheobronchial smooth muscle preparation. In the present study, using a highly sensitive radioimmunoassay
Tang, He-Bin, Nakata, Yoshihiro
core   +1 more source

A comparative study of efficacy and tolerability of bepotastine besilate (1.5%) and olopatadine hydrochloride (0.1%) eye drops in allergic conjunctivitis in a tertiary care hospital of the southern part of India

Asian Journal of Medical Sciences
Background: Allergic conjunctivitis is increasing with the rise in the levels of allergens. Drug therapy is usually needed in addition to avoidance of general allergens to treat this condition.
Sudipto Chatterjee , Vijendra R , Soumyadeep Mahapatra , Kiran Kumar L   +3 more
doaj   +1 more source

Observer-masked trial comparing efficacy of topical olopatadine (0.1%), bepotastine (1.5%), and alcaftadine (0.25%) in mild to moderate allergic conjunctivitis

Indian Journal of Ophthalmology, 2019
Purpose: With increasing environmental pollution, the incidence of allergic conjunctivitis is increasing. Newer anti-allergic medications with combined anti-histaminic and mast cell stabilization action can help reducing the use of topical steroids for ...
Lakshey Dudeja, Anuja Janakiraman, Ishani Dudeja, Kaustubh Sane, Manohar Babu   +4 more
doaj   +1 more source

UV-Spectrophotometric Estimation of Olopatadine hydrochloride in Bulk and Pharmaceutical Dosage Form by Zero, First and Second Order Derivative Methods [PDF]

, 2019
Simple and accurate UV spectrophotometric methods by Zero, First and Second order derivative method  have been developed and validated for the estimation of Olopatadine hydrochloride in bulk and its pharmaceutical dosage form.
Saudagar, Ravindranath B., Aher, Smita. S., Gawali, Jayshree S.   +2 more
core   +1 more source

Maternal and Pediatric Precision in Therapeutic Knowledge Portal (MPRINT‐KP): Landscape Analysis of Pharmacology Research in Maternal and Pediatric Patient Populations

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 3, March 2026.
ABSTRACT Pregnant women and children have been underrepresented in clinical studies due to ethical concerns and perceived vulnerabilities. This resulted in a significant gap in knowledge regarding the safety and efficacy of medications for these populations.
Xiaofu Liu, Aditi Shendre, Lei Wang, Aislinn O'Kane, Hanson Ma, Chien‐Wei Chiang, Syed S. Zaidi, Omar A. Aboshady, Gerald So, Emma M. Tillman, Lindsey M. Kirkpatrick, Maged Costantine, Shaun Grannis, Colin M. Rogerson, Christopher Bartlett, Saurabh Rahurkar, Lijun Cheng, Jiayi Ouyang, Ping Wei, Zhimo Zhu, Shangjia Li, Yirui Huang, Lingling Wang, Weidan Cao, Haoran Jiang, Jianing Liu, Samuel‐Richard Oteng, Andrew Goodwin, Jiezel Ann Faith Deypalubos, Shijun Zhang, Robert Bies, Sara K. Quinney, Lang Li   +32 more
wiley   +1 more source

EFFECTS OF OLOPATADINE, A NEW ANTIALLERGIC AGENT, ON HUMAN LIVER MICROSOMAL CYTOCHROME P450 ACTIVITIES

, 2020
This article is available online at http://dmd.aspetjournals.org ABSTRACT: Olopatadine, a new histamine H 1 receptor-selective antagonist, is a tricyclic drug containing an alkylamino moiety.
Keiko Inano, Eiichi Fuse, Takashi Kuwabara, Jiro Kajita, Hiroyuki Kobayashi   +4 more
core  

A Comparison of the Effects of Olopatadine and Ketotifen on Model Membranes [PDF]

Acta Ophthalmologica Scandinavica, 2000
ABSTRACT. Olopatadine is a human conjunctival mast cell stabilizer with anti‐histaminic activity. Ketotifen is an older molecule that possesses antihistaminic activity and is reported to have additional pharmacological properties. The interactions of these two compounds with model membranes (i.e., monolayers of 1‐stearoyl‐2‐oleoyl‐sn ...
H, Brockman, G, Graff, J, Spellman, J, Yanni   +3 more
openaire   +2 more sources

Current Insights Into Individualized Diagnosis and Treatment of Allergic Rhinitis Based on Phenotype and Endotype

World Journal of Otorhinolaryngology - Head and Neck Surgery, Volume 12, Issue 1, Page 124-135, February 2026.
ABSTRACT Allergic rhinitis (AR) is a chronic inflammatory disease of the nasal mucosa characterized by allergen sensitization and the involvement of multiple inflammatory mediators. Currently, the treatment of AR mainly includes symptomatic relief, anti‐inflammatory therapy, and nerve desensitization. However, these treatments have limitations in fully
Yue Gu, Long‐Lan Shu, Tao Lu, Da‐Yu Guan, Bo‐Wen Zheng, Pan‐Hui Xiong, Yang Shen, Yu‐Cheng Yang   +7 more
wiley   +1 more source

Safety and efficacy of olopatadine hydrochloride nasal spray for the treatment of seasonal allergic rhinitis [PDF]

, 2005
Background: A nasal spray containing the antiallergy agent olopatadine hydrochloride is being developed for the treatment of seasonal allergic rhinitis (SAR).
Brubaker, M J, Potts, S L, Meltzer, E O, Barnes, J R, Wall, G M, Larsen, L V, Roland, P S, Berger, W E, Marple, B F, Bernstein, D I, Hampel, F C, Silver, L H, Ratner, P H, Finn, A F, Dimas, C   +14 more
core  

Sustained Drug–Drug Interaction Between Cyclosporine and Apalutamide in a Patient With Metastatic Hormone‐Sensitive Prostate Cancer: A Case Report and Evaluation of CYP3A4 Induction via Pregnane X Receptor Activation by Apalutamide

Case Reports in Oncological Medicine, Volume 2026, Issue 1, 2026.
Background Apalutamide (Apa) is a key therapeutic agent for prostate cancer. Despite its efficacy, Apa is known to induce several drug‐metabolizing enzymes including cytochrome P450 3A4 (CYP3A4), raising concerns about drug–drug interactions (DDIs). This study reports a rare case of a sustained DDI between Apa and cyclosporine (CsA)—a CYP3A4 substrate ...
Yoshihisa Mimura, Takaomi Sanda, Rei Unno, Yuki Furukawa, Ryota Shizu, Kotona Motokatsu, Yuusuke Tashiro, Yoshihiko Tasaki, Yosuke Sugiyama, Tomoya Yasujima, Taku Naiki, Yasuhiro Horita, Yuji Hotta, Hiroaki Yuasa, Kouichi Yoshinari, Takahiro Yasui, Shinsuke Iida, Yoko Furukawa-Hibi, Jose I. Mayordomo   +18 more
wiley   +1 more source