Results 21 to 30 of about 458,544 (254)

Morphodynamics of carbonate beaches in the Yucatán Peninsula

Ciencias Marinas, 2009
The concept of beach morphodynamics was used to classify the swash zone of carbonate sandy beaches in the central part of the state of Yucatán (Mexico).
A Cuevas-Jiménez, J Euán-Avila
doaj   +1 more source

Ecclesia in Transitu, Di Antara Alfa dan Omega: GPI dan Notae Ecclesiae yang Baru

Gema Teologika, 2023
What are the pertinent indicators of the Church being lived by the GPI in the middle of a disruption related to its identity between oneness and independence, as well as the difficulties of the international context and nationality?
John Christianto Simon
doaj   +1 more source

De alfa a omega: Estimación de la confiabilidad ordinal. Una guía práctica

Revista Costarricense de Psicología, 2022
La presente investigación realiza un recorrido por el concepto de confiabilidad como una de las propiedades psicométricas fundamentales en la Teoría Clásica de los Test.
Nicolás Vizioli, Alejandro Pagano
doaj   +1 more source

Çok Boyutlu Test Yapılarında Alfa, Tabakalı Alfa ve Omega Güvenirlik Katsayılarının Karşılaştırılması

Necmettin Erbakan Üniversitesi Ahmet Keleşoğlu Eğitim Fakültesi Dergisi, 2023
Bu araştırmanın amacı, çok boyutlu test yapılarının güvenirliğinin incelenmesidir. Bu amaçla iki boyutlu bir test için örneklem büyüklüğü (100,200 ve 400), boyutlar arası korelasyon (0,00 ve 0,50), maddeler arası korelasyon (0,30-0,50 ve ≥0,65) , test ...
Sümeyra Soysal
doaj   +1 more source

A single centre, real world experience of T-DM1 in the treatment of HER2-positive metastatic breast cancer patients in India

Journal of Applied Pharmaceutical Research
Background: HER2 (Human Epidermal Growth Receptor 2) positive breast cancer is an aggressive subtype. Treatment for patients with HER2-positive breast cancer has advanced significantly over time with the introduction of targeted therapies like ...
Vindhya Vasini, Mohana Vamsy, Monal Dayal, Pawan Shinkar   +3 more
doaj   +1 more source

A new approach to building artificial neural networks and medicine

Annals of Mechnikov's Institute, 2021
Numerous attempts to use neural networks in medicine remain unsuccessful to this day because of an old mistake in the development of neural networks.
Boris Zlotin, Vladimir Proseanic, Boris Farber, Anatoly Guin, Ivan Nehrishnyi Sr, Ivan Nehrishnyi Jr, Vladimir Matsenko, Anton Belyakov, Gafur Zainiev   +8 more
doaj  

Programmable mRNA therapeutics for controlled epigenomic modulation of single and multiplexed gene expression in diverse diseases

Nature Communications
Pathogenic gene dysregulation can be attributed to chromatin state change that pre-transcriptionally regulates expression. Recent breakthroughs elucidating the rules governing this DNA control layer, an epigenetic code, unlock a modality in precision ...
Charles W. O’Donnell, Jeremiah D. Farelli, Houda Belaghzal, Justin Chen, Lauren Beech, James Sullivan, Chevaun Morrison-Smith, Stephen Siecinski, Adam Katz, Samuel Mildrum, Mayur Gurnani, Prachi Dhanania, Caitlyn R. Webb, Giuliana Castello Coatti, Pranjali Rumale, Daniel F. G. Costa, Marcus I. Gibson, Yaoyu E. Wang, Joseph V. Newman, Thomas G. McCauley   +19 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Targeted transcriptional downregulation of MYC using epigenomic controllers demonstrates antitumor activity in hepatocellular carcinoma models

Nature Communications
Dysregulation of master regulator c-MYC (MYC) plays a central role in hepatocellular carcinoma (HCC) and other cancers but remains an elusive target for therapeutic intervention.
William Senapedis, Kayleigh M. Gallagher, Elmer Figueroa, Jeremiah D. Farelli, Robert Lyng, J. Graeme Hodgson, Charles W. O’Donnell, Joseph V. Newman, Madison Pacaro, Stephen K. Siecinski, Justin Chen, Thomas G. McCauley   +11 more
doaj   +1 more source

Next-generation sequencing of drug resistant Mycobacterium tuberculosis clinical isolates in low-incidence countries

Инфекция и иммунитет, 2020
Drug resistant tuberculosis (TB), especially multidrug (MDR) and extensively drug-resistant (XDR) TB, is still a serious problem in global TB control.
E. Sodja, N. Toplak, S. Koren, M. Kovač, S. Truden, M. Žolni-Dovč   +5 more
doaj   +1 more source