Results 41 to 50 of about 903,347 (269)
Morphodynamics of carbonate beaches in the Yucatán Peninsula
Ciencias Marinas, 2009 The concept of beach morphodynamics was used to classify the swash zone of carbonate sandy beaches in the central part of the state of Yucatán (Mexico).
A Cuevas-Jiménez, J Euán-Avila
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Markov uniqueness of degenerate elliptic operators [PDF]
, 2009 Let $\Omega$ be an open subset of $\Ri^d$ and $H_\Omega=-\sum^d_{i,j=1}\partial_i c_{ij} \partial_j$ a second-order partial differential operator on $L_2(\Omega)$ with domain $C_c^\infty(\Omega)$ where the coefficients $c_{ij}\in W^{1,\infty}(\Omega ...
Robinson, Derek W., Sikora, Adam
core
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
The Mosaic Floors of the Church at Hazor-Ashdod, Israel
Journal of Mosaic Research, 2020 A basilica has been found in Hazor-Ashdod, with a narthex in the west and a hall attached on the north side. The eastern part has not survived, but a capital of an altar table leg has been found, not in situ.
Lihi HABAS
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Inhomogeneous refinement equations with random affine maps
, 2015 Given a probability space $(\Omega,{\mathcal A},P)$, random variables $L,M\colon\Omega\to\mathbb R$ and $g\in L^1(\mathbb R)$ we obtain two characterizations of these $f\in L^1(\mathbb R)$ which are solutions of the inhomogeneous refinement equation with
Kapica, Rafał, Morawiec, Janusz
core +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Improvement of Semen Quality in Holstein Bulls during Heat Stress by Dietary Supplementation of Omega-3 Fatty Acids [PDF]
International Journal of Fertility and Sterility, 2011 Background Long-chain polyunsaturated fatty acids (PUFAs) of the omega-3 family are important for sperm membrane integrity, sperm motility and viability.
Hamid Gholami +3 more
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