Results 301 to 310 of about 73,909 (338)
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2010
Publisher Summary Omeprazole is a proton pump inhibitor that inhibits secretion of gastric acid by irreversibly blocking the enzyme system of hydrogen/potassium adenosine triphosphatase, the “proton pump” of the gastric parietal cell. The drug is used in conditions, where the inhibition of gastric acid secretion may be beneficial, including aspiration
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Publisher Summary Omeprazole is a proton pump inhibitor that inhibits secretion of gastric acid by irreversibly blocking the enzyme system of hydrogen/potassium adenosine triphosphatase, the “proton pump” of the gastric parietal cell. The drug is used in conditions, where the inhibition of gastric acid secretion may be beneficial, including aspiration
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Scandinavian Journal of Gastroenterology, 1995
Omeprazole causes irreversible inhibition of the hydrogen/potassium adenosine triphosphatase enzyme, leading to a marked reduction in both acid secretion and volume of gastric juice. Reported side-effects include nausea, vomiting, diarrhoea, constipation, and headache.
M. W. Whitehead +5 more
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Omeprazole causes irreversible inhibition of the hydrogen/potassium adenosine triphosphatase enzyme, leading to a marked reduction in both acid secretion and volume of gastric juice. Reported side-effects include nausea, vomiting, diarrhoea, constipation, and headache.
M. W. Whitehead +5 more
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Texicological studies on omeprazole
Scandinavian Journal of Gastroenterology, 1985As part of the safety evaluation of the gastric antisecretory drug, omeprazole, toxicological studies have been performed in several species of animals. The acute toxicity after oral administration to rodents was low. The oral LD50 value was above 4 g/kg. The general toxicity after repeated administration has been studied in rats and dogs.
C Lundberg +4 more
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Tautomeric polymorphism in omeprazole
Chemical Communications, 2007Crystalline omeprazole exists as solid solutions of two tautomers in a continuous composition range, and this raises questions pertaining to the definition of the term polymorph.
Prashant M. Bhatt, Gautam R. Desiraju
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2007
Omeprazole was the first of a new class of drugs, the proton pump inhibitors (PPIs), that control acid in the stomach, and elucidation of its mechanism of action was a major achievement. This article describes the background that led to my work on omeprazole, the subsequent search for esomeprazole, a PPI that would improve on omeprazole, and work on ...
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Omeprazole was the first of a new class of drugs, the proton pump inhibitors (PPIs), that control acid in the stomach, and elucidation of its mechanism of action was a major achievement. This article describes the background that led to my work on omeprazole, the subsequent search for esomeprazole, a PPI that would improve on omeprazole, and work on ...
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Mechanism of Action of Omeprazole
Scandinavian Journal of Gastroenterology, 1986The inhibitory effect of omeprazole on gastric acid secretion in vivo and in vitro is presented. In the gastric fistula dog omeprazole was found to be about 10 times more potent than cimetidine. When omeprazole was administered in vivo, the inhibition of acid secretory rates was found to correlate with the degree of inhibition of the gastric H+K+ATPase
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Gastroenterology Nursing, 1990
The treatment of patients with Zollinger-Ellison syndrome has represented a challenge in the past. Losec Delayed-Release Capsules may provide these patients with a well-tolerated alternative, allowing them a more natural lifestyle. In addition, Losec may also offer benefits to the patient suffering from severe gastroesophageal reflux disease in whom ...
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The treatment of patients with Zollinger-Ellison syndrome has represented a challenge in the past. Losec Delayed-Release Capsules may provide these patients with a well-tolerated alternative, allowing them a more natural lifestyle. In addition, Losec may also offer benefits to the patient suffering from severe gastroesophageal reflux disease in whom ...
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American Journal of Gastroenterology, 1999
TO THE EDITOR: I would like to commend Dr. Levin et al. for their article in the July issue titled "Omeprazole improves peak expiratory flow rate and quality of life in asthmatics with gastroesophageal reflux"(1). Increasingly, it is being recognized that the ability of asthmatics to carry on their normal activities at school, work, and play and to ...
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TO THE EDITOR: I would like to commend Dr. Levin et al. for their article in the July issue titled "Omeprazole improves peak expiratory flow rate and quality of life in asthmatics with gastroesophageal reflux"(1). Increasingly, it is being recognized that the ability of asthmatics to carry on their normal activities at school, work, and play and to ...
openaire +2 more sources