Results 101 to 110 of about 52,366 (249)

Targeting hexokinase 2 to induce breast cancer cell senescence

British Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof, Katarina Cisarova, Sandra Burgstaller, Mia Schwerer, Markus Absenger‐Novak, Philipp J. Jost, Roland Malli, Wolfgang F. Graier, Robert Lukowski   +8 more
wiley   +1 more source

Association of Reduction in Continuity of Care During COVID‐19 Pandemic With Cardiovascular Diseases, Kidney Failure and All‐Cause Mortality for People With Diabetes: A Cohort Study in Hong Kong

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction Continuity of care, a critical component of high‐quality primary care, was interrupted in people with diabetes mellitus during the COVID‐19 pandemic in Hong Kong. Research on whether reduced continuity of care was associated with higher complications and mortality risks is lacking.
Yuk Kam Yau, Meijiao Li, Jianchao Quan, Karen Ann Grépin, Gary Kui Kai Lau, Ivy Lynn Mak, Chak Sing Lau, Ian Chi Kei Wong, David Vai Kiong Chao, Welchie Wai Kit Ko, Cindy Lo Kuen Lam, Eric Yuk Fai Wan   +11 more
wiley   +1 more source

Phenotypic characterization of Arabidopsis thaliana mutants that alleviate root growth defects in a vitamin B6 biosynthesis mutant

The FEBS Journal, EarlyView.
Vitamin B6 is a critical molecule for plant metabolism and development. Rsr4‐1, a loss‐of‐function mutant in a vitamin B6 biosynthesis gene, has a distinct short root phenotype. Here we describe five novel suppressor mutants with an rsr4‐1 background that have normalized root growth and distinct phenotypic and molecular characteristics, representing a ...
Marcelina Parra, Paige Henning, Clayton Bailes, Sanja Roje, Hanjo Hellmann   +4 more
wiley   +1 more source

The Practice of Nurse Managers, Their Support Needs and the Importance of Shared Leadership: A Multicentre International Qualitative Research

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To shed new light on the management practice and needs for support, mentoring and continuous education of nurse managers (head nurses and assistant head nurses) during and since the COVID‐19 pandemic to identify the innovative strategies they put in place to mobilise teams and foster a healthy work environment.
Johanne Déry, Maxime Paquet, Geneviève Lavigne, Sabrina Fournelle, Jolianne Bolduc, Héroldine Lucien, Nathalie Folch, Krystel Vasserot   +7 more
wiley   +1 more source

Association between obstructive sleep apnea (OSA) and COVID‐19 severity

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Obstructive sleep apnea and sleep‐related hypoxia have been associated with higher rates of hospitalization and mortality among patients with Coronavirus disease 2019 (COVID‐19). We further explored the association between obstructive sleep apnea, COVID‐19 severity and related mortality.
Oria Nassi‐Liberman, Bernice Oberman, Tamar Strahl, Noga Yosef, Dekel Shlomi   +4 more
wiley   +1 more source

[Advertisement: Omicron] [PDF]

IEEE Electrical Insulation Magazine, 2021
openaire   +1 more source

Persistent Sleep Disturbance Following Pandemic Lockdowns: Longitudinal Findings From the UK COVID‐19 Symptom Study Biobank

Journal of Sleep Research, EarlyView.
ABSTRACT Sleep disturbance and fatigue were highly prevalent during the COVID‐19 pandemic, in both infected and non‐infected individuals, though mostly assessed cross‐sectionally. To assess these symptoms after lockdown cessation, we conducted a prospective longitudinal study in a large UK cohort.
Barbara Toson, Nathan J. Cheetham, Julia R. B. Brown, Carole H. Sudre, Simon Proctor, Vicky Bowyer, Nicholas R. Harvey, Desaline Joseph, COVID Symptom Study Biobank Consortium, Adam Birdseye, Claire J. Steves, Sutapa Mukherjee, Emma L. Duncan   +12 more
wiley   +1 more source

Respiratory diphtheria in the time of Omicron

Communicable Diseases Intelligence
Diphtheria is a potentially fatal bacterial infection caused by toxin-producing strains of corynebacteria, most often Corynebacterium diphtheriae and less commonly Corynebacterium ulcerans. Incidence of the disease has fallen significantly since the introduction of vaccination programs; it is now rare in countries with high vaccination coverage such as
Annabeth, Simpson, Paul, Douglas, Jenny, Draper, Vitali, Sintchenko, Zoe, Cutcher, Daniel, Ashton   +5 more
openaire   +2 more sources

Too Much of a Good Thing? Telework Intensity and Workplace Experiences

Kyklos, EarlyView.
ABSTRACT At a time when numerous organisations are urging a return to the office while many employees prefer to continue teleworking, it is crucial to ascertain the optimal level of telework intensity. In the present study, we determine this ideal level with respect to self‐rated employee attitudes, behaviour, well‐being, social relations and ...
Eline Moens, Louis Lippens, Kathleen Vangronsvelt, Ans De Vos, Stijn Baert   +4 more
wiley   +1 more source

Omicron severity: milder but not mild [PDF]

The Lancet, 2022
Nealon, Joshua, Cowling, Benjamin J
openaire   +2 more sources