Results 111 to 120 of about 368,665 (261)

Fasting Metabolite Panel for OGTT-Free Diagnosis of Gestational Diabetes Mellitus: A Machine Learning Approach Validated in Dual Cohorts

Diabetes, Metabolic Syndrome and Obesity
Binbin Yin,1,* Yiyun Shen,1,* Qianwen Zhang,2,* Rongchang Chen,2,* Xue Zhang,2 Ziqing Kong,2,3 Yuning Zhu1,4– 6 1Department of Laboratory Medicine, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou ...
Yin B, Shen Y, Zhang Q, Chen R, Zhang X, Kong Z, Zhu Y   +6 more
doaj  

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source

Application of Omics and Systems Medicine in Bladder Cancer

, 2017
Bladder cancer (BC) is the ninth most common cancer in the world. Smoking remains the main disease risk factor which is responsible for about half of the diagnosed BC cases.
Frantzi M., Merseburger A.S., Akand, Murat, Latosinska A.   +3 more
core   +1 more source

Enhancing Super‐Resolution Spatial Transcriptomics Data by Transfer Learning

Advanced Science, EarlyView.
SpotZoomer employs a transfer‐learning‐based strategy to enhance the resolution of Visium data by leveraging available high‐resolution priors. The resulting super‐resolved maps enable sharper delineation of cell boundaries and more precise inference of cell–cell communication patterns that would otherwise remain obscured at native resolution.
Xiaoyu Li, Lihua Zhang, Wenwen Min
wiley   +1 more source

CA9‐Targeted PET Imaging for Noninvasive Discrimination of Clear Cell Renal Cell Carcinoma and Associated Tumor Biological Features

Advanced Science, EarlyView.
CA9‐targeted PET imaging could be a noninvasive approach to characterize clear cell renal cell carcinoma and associated tumor biology. PET uptake correlates with tumor CA9 expression and is linked to angiogenic activity, immune remodeling, and metabolic reprogramming.
Kailei Chen, Sixuan Cheng, Jian Shi, Ruijie Liu, Yilong Wu, Xin Zheng, Xinlun Song, Yunxuan Zhang, Lei Liu, Zhihao Wei, Qi Wang, Xinwei Li, Zirui Dong, Yuenan Liu, Hongmei Yang, Xiaoli Lan, Chunxia Qin, Dawei Jiang, Keshan Wang, Xiaoping Zhang   +19 more
wiley   +1 more source

Unraveling Plant Recombination Patterns: Insights From Genome k‐mers

Plant Direct
Crossover recombination is a pivotal event that takes place during meiosis of germinal cells, leading to the rearrangement of parental chromosomes and generating novel allele combinations, thereby enhancing genetic diversity.
Mauricio Peñuela, Camila Riccio‐Rengifo, Jorge Finke, Camilo Rocha   +3 more
doaj   +1 more source

PolyG Fibrils Coalesce Into Nuclear Ribbons That Engage Proteostasis Machinery in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
In NIID, expanded NOTCH2NLC repeats give rise to nuclear polyG inclusions. Tracer‐guided in situ cryo‐electron tomography enables cross‐scale structural analysis from mouse brain to native neuronal nuclei, revealing dense‐core/peripheral‐halo inclusions built from compact polyG ribbons.
Hui Dong, Yongcheng Pan, Zhiyao Tang, Yuxuan Yao, Guicong Zhang, Junpu Wang, Haonan Xiao, Yun Tian, Beisha Tang, Dan Li, Qiang Guo, Ruijun Tian, Qiong Liu, Cong Liu   +13 more
wiley   +1 more source

Development of a severe rat refeeding syndrome model and mathematical modeling of the associated hypophosphatemia

npj Systems Biology and Applications
Refeeding syndrome (RFS) is a life-threatening metabolic complication caused by refeeding in malnourished patients and is a barrier to early nutritional supplementation.
Hiroaki Kato, Ippei Yamaoka, Hiroyuki Kubota   +2 more
doaj   +1 more source

A Programmable Calcification Nanoplatform for Loco‐Regional Calcification‐Immune Hepatocellular Carcinoma Therapy

Advanced Science, EarlyView.
An in situ‐grown BP‐CaO2 nanoplatform supplies coordinated Ca2+, endogenous phosphate, and oxidative stress to convert tumor calcification from a passive endpoint into an active immune‐remodeling process. Widespread hydroxyapatite deposition is visualized by CT, while multi‐omics reveals MCOLN2 as a calcium‐responsive mediator linking biomineralization
Long Liu, Peng Li, Zhixiang Lu, Shuqin Xu, Juanjuan Wang, Kai Ma, Haodong Yu, Can Zhou, Hu Chen, Gang Liu, Yi Lyu, Shuang Bai   +11 more
wiley   +1 more source

Computational identification of multi-target natural compounds from Sesbania grandiflora as potential therapeutic agents against Klebsiella pneumoniae

Scientific Reports
Klebsiella pneumoniae (K. pneumoniae) is a Gram-negative bacterium that causes severe community- and hospital-acquired infections. Its rising multidrug resistance complicates therapy, highlighting the need for novel drugs with broad-spectrum, multi ...
Harshit Sajal, Aswin Mohan, Vishal Ravi, K. Anjali, Rajesh Raju, Niyas Rehman, Anuroopa G. Nadh   +6 more
doaj   +1 more source