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Phosphoproteomics technologies and applications in plant biology research [PDF]
Frontiers in Plant Science, 2015 Protein phosphorylation has long been recognized as an essential mechanism to regulate many important processes of plant life. However, studies on phosphorylation mediated signaling events in plants are challenged with low stoichiometry and dynamic ...
Sixue Chen +2 more
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Lighting Up T Lymphocyte Signaling with Quantitative Phosphoproteomics [PDF]
Frontiers in Immunology, 2017 Phosphorylation is the most abundant post-translational modification, regulating several aspects of protein and cell function. Quantitative phosphoproteomics approaches have expanded the scope of phosphorylation analysis enabling the quantification of ...
Raquel Castillo-González +1 more
exaly +7 more sources
Recent advances in phosphoproteomics based on mass spectrometry and its clinical application prospects [PDF]
Frontiers in PharmacologyProtein phosphorylation, a key post-translational modification, plays a crucial role in regulating cellular activities in eukaryotes. Dysregulation of phosphorylation is closely linked to the pathogenesis of various diseases Recent advancements in ...
Jiuyu Gao +5 more
doaj +2 more sources
Phosphoproteomics Sample Preparation Impacts Biological Interpretation of Phosphorylation Signaling Outcomes [PDF]
Cells, 2021 The influence of phosphoproteomics sample preparation methods on the biological interpretation of signaling outcome is unclear. Here, we demonstrate a strong bias in phosphorylation signaling targets uncovered by comparing the phosphoproteomes generated ...
Bharath Sampadi +2 more
doaj +3 more sources
Cell Reports, 2018 Summary: Despite its low cellular abundance, phosphotyrosine (pTyr) regulates numerous cell signaling pathways in health and disease. We applied comprehensive phosphoproteomics to unravel differential regulators of receptor tyrosine kinase (RTK ...
Anamarija Pfeiffer +2 more
exaly +3 more sources
Phosphoproteomics of Primary Cells Reveals Druggable Kinase Signatures in Ovarian Cancer
Cell Reports, 2017 Our understanding of the molecular determinants of cancer is still inadequate because of cancer heterogeneity. Here, using epithelial ovarian cancer (EOC) as a model system, we analyzed a minute amount of patient-derived epithelial cells from either ...
Stefano Confalonieri +2 more
exaly +3 more sources
Cell Reports, 2018 Summary: Multiple protein kinases regulate cell-cycle progression, of which the cyclin-dependent kinases (CDKs) are thought to act as upstream master regulators.
Helen R Flynn +2 more
exaly +3 more sources
A Decade of Pollen Phosphoproteomics [PDF]
International Journal of Molecular Sciences, 2021 Angiosperm mature pollen represents a quiescent stage with a desiccated cytoplasm surrounded by a tough cell wall, which is resistant to the suboptimal environmental conditions and carries the genetic information in an intact stage to the female gametophyte.
Božena Klodová, Jan Fíla
openaire +3 more sources
Phosphoproteomics for the Masses [PDF]
ACS Chemical Biology, 2010 Protein phosphorylation serves as a primary mechanism of signal transduction in the cells of biological organisms. Technical advancements over the last several years in mass spectrometry now allow for the large-scale identification and quantitation of in vivo phosphorylation at unprecedented levels.
Paul A, Grimsrud +4 more
openaire +2 more sources
Cell Reports, 2021 Summary: Epithelial-mesenchymal transition (EMT) of the retinal pigment epithelium (RPE) is associated with several blinding retinal diseases. Using proteomics and phosphoproteomics studies of human induced pluripotent stem cell-derived RPE monolayers ...
Joseph L. Mertz +6 more
doaj +1 more source