Results 1 to 10 of about 27,576 (286)
Cell Metabolism, 2022 Exercise induces signaling networks to improve muscle function and confer health benefits. To identify divergent and common signaling networks during and after different exercise modalities, we performed a phosphoproteomic analysis of human skeletal ...
Christian Strini Carl +2 more
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Spatiotemporally resolved subcellular phosphoproteomics [PDF]
Proceedings of the National Academy of Sciences, 2021 Significance As one of the most important post-translational modifications, phosphorylation is both highly abundant and dynamically regulated in cells.
Yanjun Liu +6 more
semanticscholar +3 more sources
Cell Reports, 2018 Summary: Despite its low cellular abundance, phosphotyrosine (pTyr) regulates numerous cell signaling pathways in health and disease. We applied comprehensive phosphoproteomics to unravel differential regulators of receptor tyrosine kinase (RTK ...
Anamarija Pfeiffer +2 more
exaly +3 more sources
Phosphoproteomics: a valuable tool for uncovering molecular signaling in cancer cells
Expert Review of Proteomics, 2021 Introduction Many pathologies, including cancer, have been associated with aberrant phosphorylation-mediated signaling networks that drive altered cell proliferation, migration, metabolic regulation, and can lead to systemic inflammation ...
Forest M White
exaly +2 more sources
Cell Reports, 2022 Summary Acute myeloid leukemia (AML) is a heterogeneous disease with variable patient responses to therapy. Selinexor, an inhibitor of nuclear export, has shown promising clinical activity for AML.
Kristina B Emdal +2 more
exaly +2 more sources
Cell Reports, 2018 Summary: Multiple protein kinases regulate cell-cycle progression, of which the cyclin-dependent kinases (CDKs) are thought to act as upstream master regulators.
Matthew P Swaffer +2 more
exaly +3 more sources
Phosphoproteomics-based systems analysis of signal transduction networks [PDF]
Frontiers in Physiology, 2012 Signal transduction systems coordinate complex cellular information to regulate biological events such as cell proliferation and differentiation. Although the accumulating evidence on widespread association of signaling molecules has revealed essential ...
Hiroko eKozuka-Hata +2 more
doaj +3 more sources
Phosphoproteomics of Primary Cells Reveals Druggable Kinase Signatures in Ovarian Cancer
Cell Reports, 2017 Our understanding of the molecular determinants of cancer is still inadequate because of cancer heterogeneity. Here, using epithelial ovarian cancer (EOC) as a model system, we analyzed a minute amount of patient-derived epithelial cells from either ...
Chiara Francavilla +2 more
exaly +3 more sources
Metformin inhibits the proliferation of hepatocellular carcinoma cells through inducing ferroptosis analyzed by phosphoproteomics [PDF]
Frontiers in OncologyIntroductionThis study aims to investigate the effects of Metformin on hepatocellular carcinoma cell lines, cell lines and explores the molecular mechanisms underlying.MethodsBel-7402 and HepG2 cells were treated with varying concentrations of Metformin ...
Jihan Sun +7 more
doaj +2 more sources