Results 21 to 30 of about 27,576 (286)
Cell Reports, 2021 Summary: Epithelial-mesenchymal transition (EMT) of the retinal pigment epithelium (RPE) is associated with several blinding retinal diseases. Using proteomics and phosphoproteomics studies of human induced pluripotent stem cell-derived RPE monolayers ...
Joseph L. Mertz +6 more
doaj +1 more source
Proteogenomic characterization of cholangiocarcinoma
Hepatology, EarlyView., 2022 Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng +18 more
wiley +1 more source
Plants, 2023 Protein phosphatase 2A (PP2A) is a heterotrimeric conserved serine/threonine phosphatase complex that includes catalytic, scaffolding, and regulatory subunits.
Ahmed Elshobaky +3 more
doaj +1 more source
A data-independent acquisition-based global phosphoproteomics system enables deep profiling
Nature Communications, 2021 Phosphoproteomics can provide insights into cellular signaling dynamics. To achieve deep and robust quantitative phosphoproteomics profiling for minute amounts of sample, we here develop a global phosphoproteomics strategy based on data-independent ...
Reta Birhanu Kitata +8 more
semanticscholar +1 more source
Biomedicines, 2022 Small membrane-derived extracellular vesicles have been proposed as participating in several cancer diseases, including breast cancer (BC). We performed a phosphoproteomic analysis of breast cancer-derived small extracellular vesicles (sEVs) to provide ...
Zoran Minic +6 more
doaj +1 more source
A streamlined tandem tip-based workflow for sensitive nanoscale phosphoproteomics
bioRxiv, 2022 A streamlined tandem tip-based workflow for sensitive nanoscale phosphoproteomics is developed, reducing sample loss and processing time, allowing the phosphoproteome profiling of mass-limited samples at the low nanogram level.
Chia-Feng Tsai +16 more
semanticscholar +1 more source
Frontiers in Physiology, 2023 Human airway smooth muscle (HASM) is the primary target of ßAR agonists used to control airway hypercontractility in asthma and chronic obstructive pulmonary disease (COPD).
Isabella Cattani-Cavalieri +5 more
doaj +1 more source
Phosphoproteomics technologies and applications in plant biology research
Frontiers in Plant Science, 2015 Protein phosphorylation has long been recognized as an essential mechanism to regulate many important processes of plant life. However, studies on phosphorylation mediated signaling events in plants are challenged with low stoichiometry and dynamic ...
Jinna eLi +6 more
doaj +1 more source
Minimal Information About Sample Preparation for Phosphoproteomics [PDF]
, 2009 This guideline describes parameters and conditions involved in phosphopeptide sample preparation. It covers from the description and preparation of the cells and tissues to the fractionation and specific enrichment of phosphopeptides for MS analysis. The
David Ovelleiro +3 more
core +2 more sources
Quantitative plant phosphoproteomics [PDF]
Current Opinion in Plant Biology, 2011 Protein phosphorylation is a major post-translational modification in plants crucial for the regulation of diverse cellular functions. In the early stages of this field, efforts were focused on the qualitative detection, identification, and cataloging of in vivo protein phosphorylation sites.
Kelli G, Kline-Jonakin +2 more
openaire +2 more sources