Results 21 to 30 of about 14,144 (239)

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Proteomic and phosphoproteomic analyses identify liver-related signaling in retinal pigment epithelial cells during EMT

Cell Reports, 2021
Summary: Epithelial-mesenchymal transition (EMT) of the retinal pigment epithelium (RPE) is associated with several blinding retinal diseases. Using proteomics and phosphoproteomics studies of human induced pluripotent stem cell-derived RPE monolayers ...
Joseph L. Mertz, Srinivasa R. Sripathi, Xue Yang, Lijun Chen, Noriko Esumi, Hui Zhang, Donald J. Zack   +6 more
doaj   +1 more source

Protein–Protein Interactions and Quantitative Phosphoproteomic Analysis Reveal Potential Mitochondrial Substrates of Protein Phosphatase 2A-B’ζ Holoenzyme

Plants, 2023
Protein phosphatase 2A (PP2A) is a heterotrimeric conserved serine/threonine phosphatase complex that includes catalytic, scaffolding, and regulatory subunits.
Ahmed Elshobaky, Cathrine Lillo, Kristian Persson Hodén, Amr R. A. Kataya   +3 more
doaj   +1 more source

Optimized Suspension Trapping Method for Phosphoproteomics Sample Preparation [PDF]

, 2023
A successful mass spectrometry-based phosphoproteomics analysis relies on effective sample preparation strategies. Suspension trapping (S-Trap) is a novel, rapid, and universal method of sample preparation that is increasingly applied in bottom-up ...
Fujia Wang (4753881), Tim Veth (16378611), Marije Kuipers, Kelly E. Stecker (16378617), Maarten Altelaar, Tim Veth, Kelly E. Stecker, Maarten Altelaar (6112361), Fujia Wang, Marije Kuipers (16378614)   +9 more
core   +2 more sources

Phosphoproteomic Analysis of Breast Cancer-Derived Small Extracellular Vesicles Reveals Disease-Specific Phosphorylated Enzymes

Biomedicines, 2022
Small membrane-derived extracellular vesicles have been proposed as participating in several cancer diseases, including breast cancer (BC). We performed a phosphoproteomic analysis of breast cancer-derived small extracellular vesicles (sEVs) to provide ...
Zoran Minic, Nico Hüttmann, Suttinee Poolsup, Yingxi Li, Vanessa Susevski, Emil Zaripov, Maxim V. Berezovski   +6 more
doaj   +1 more source

Knowledge-Based Analysis for Detecting Key Signaling Events from Time-Series Phosphoproteomics Data.

PLoS Computational Biology, 2015
Cell signaling underlies transcription/epigenetic control of a vast majority of cell-fate decisions. A key goal in cell signaling studies is to identify the set of kinases that underlie key signaling events.
Pengyi Yang, Xiaofeng Zheng, Vivek Jayaswal, Guang Hu, Jean Yee Hwa Yang, Raja Jothi   +5 more
doaj   +1 more source

Quantitative phosphoproteomic analysis reveals unique cAMP signaling pools emanating from AC2 and AC6 in human airway smooth muscle cells

Frontiers in Physiology, 2023
Human airway smooth muscle (HASM) is the primary target of ßAR agonists used to control airway hypercontractility in asthma and chronic obstructive pulmonary disease (COPD).
Isabella Cattani-Cavalieri, Yue Li, Jordyn Margolis, Amy Bogard, Moom R. Roosan, Rennolds S. Ostrom   +5 more
doaj   +1 more source

Applications and prospects of phosphoproteomics in renal disease research [PDF]

PeerJ
Introduction Phosphoproteomics, an advanced branch of molecular biology, utilizes specific techniques such as mass spectrometry, affinity chromatography, and bioinformatics analysis to explore protein phosphorylation, shedding light on the cellular ...
XueJia Zheng, LingLing Zhou, TianTian Xu, GuoYing Wang, YaLi Peng, ChunMei Wen, MengYao Wu, HuiHui Tao, Yong Dai   +8 more
doaj   +2 more sources

Trypanosomatid Phosphoproteomics

, 2014
The reversible phosphorylation of serine, threonine and tyrosine plays an important role in the biology of trypanosomatids. The identification and quantification of phosphorylation site dynamics will not only assist the elucidation of signaling pathways ...
Urbaniak, Mick
core   +4 more sources

Identification of Arginine Phosphorylation in Mycolicibacterium smegmatis

Microbiology Spectrum, 2022
Tuberculosis is a leading cause of worldwide infectious mortality. The prevalence of multidrug-resistant Mycobacterium tuberculosis infections drives an urgent need to exploit new drug targets.
Emmanuel C. Ogbonna, Henry R. Anderson, Karl R. Schmitz   +2 more
doaj   +1 more source