Results 21 to 30 of about 14,675 (189)
Phosphoproteomics profiling of mice with genetic deletions in Ku70
, 2023 Phosphoproteomics data for WT, Ku70 +/- and Ku70 ...
Kaakoush,Nadeem +2 more
core +1 more source
Identification of Arginine Phosphorylation in Mycolicibacterium smegmatis
Microbiology Spectrum, 2022 Tuberculosis is a leading cause of worldwide infectious mortality. The prevalence of multidrug-resistant Mycobacterium tuberculosis infections drives an urgent need to exploit new drug targets.
Emmanuel C. Ogbonna +2 more
doaj +1 more source
Phosphoproteomic Profiling of the Myocyte [PDF]
Circulation: Cardiovascular Genetics, 2011 Protein phosphorylation underpins major cellular processes including energy metabolism, signal transduction, excitation-contraction coupling, apoptosis, and cell survival mechanisms and is thus critical to the myocyte. Targeted approaches, whereby a handful of phosphoproteins are investigated, can suffer from a relatively narrow view of cellular ...
Alistair V G, Edwards +2 more
openaire +2 more sources
Cells, 2021 To investigate the biological role of protein phosphorylation in human nonfunctional pituitary neuroendocrine tumors (NF-PitNETs), proteins extracted from NF-PitNET and control tissues were analyzed with tandem mass tag (TMT)-based quantitative ...
Jiajia Li +4 more
doaj +1 more source
State‐of‐the‐art in phosphoproteomics [PDF]
PROTEOMICS, 2005 Abstract Presently, phosphorylation of proteins is the most studied and best understood PTM. However, the analysis of phosphoproteins and phosphopeptides is still one of the most challenging tasks in contemporary proteome research.
Joerg, Reinders, Albert, Sickmann
openaire +2 more sources
Impact of Phosphoproteomics in the Era of Precision Medicine for Prostate Cancer
Frontiers in Oncology, 2018 Prostate cancer is the most common malignancy in men in the United States. While androgen deprivation therapy results in tumor responses initially, there is relapse and progression to metastatic castration-resistant prostate cancer.
Johnny R. Ramroop +5 more
doaj +1 more source
Cells, 2022 Interleukin-33 (IL-33), a member of the IL-1 superfamily cytokines, is an endogenous danger signal and a nuclear-associated cytokine. It is one of the essential mediators of both innate and adaptive immune responses.
Devasahayam Arokia Balaya Rex +7 more
doaj +1 more source
Bioscience Reports, 2005 Protein phosphorylation is directly or indirectly involved in all important cellular events. The understanding of its regulatory role requires the discovery of the proteins involved in these processes and how, where and when protein phosphorylation takes place.
Roberto, Raggiaschi +2 more
openaire +2 more sources
Interrogating the hidden phosphoproteome [PDF]
PROTEOMICS, 2017 Postgenomic studies continue to highlight the potential clinical importance of protein phosphorylation signaling pathways in drug discovery. Unfortunately, the dynamic range and variable stoichiometry of protein phosphorylation continues to stymie efforts to achieve comprehensive characterization of the human phosphoproteome.
Un-Beom, Kang +2 more
openaire +2 more sources
Frontiers in Plant Science, 2017 Mass spectrometry (MS)-based large scale phosphoproteomics has facilitated the investigation of plant phosphorylation dynamics on a system-wide scale. However, generating large scale data sets for membrane phosphoproteins usually requires fractionation ...
Xu Na Wu +5 more
doaj +1 more source