Results 41 to 50 of about 27,576 (286)
Impact of Phosphoproteomics in the Era of Precision Medicine for Prostate Cancer
Frontiers in Oncology, 2018 Prostate cancer is the most common malignancy in men in the United States. While androgen deprivation therapy results in tumor responses initially, there is relapse and progression to metastatic castration-resistant prostate cancer.
Johnny R. Ramroop +5 more
doaj +1 more source
A golden age for working with public proteomics data [PDF]
, 2017 Data sharing in mass spectrometry (MS)-based proteomics is becoming a common scientific practice, as is now common in the case of other, more mature 'omics' disciplines like genomics and transcriptomics.
Martens, Lennart +1 more
core +1 more source
Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases
eLife, 2016 Mutations in Park8, encoding for the multidomain Leucine-rich repeat kinase 2 (LRRK2) protein, comprise the predominant genetic cause of Parkinson's disease (PD).
Martin Steger +16 more
semanticscholar +1 more source
Bioscience Reports, 2005 Protein phosphorylation is directly or indirectly involved in all important cellular events. The understanding of its regulatory role requires the discovery of the proteins involved in these processes and how, where and when protein phosphorylation takes place.
Roberto, Raggiaschi +2 more
openaire +2 more sources
Estimating the total number of phosphoproteins and phosphorylation sites in eukaryotic proteomes [PDF]
, 2017 Background: Phosphorylation is the most frequent post-translational modification made to proteins and may regulate protein activity as either a molecular digital switch or a rheostat.
Amoutzias, Grigoris D +5 more
core +2 more sources
Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription. [PDF]
, 2020 Deregulated expression of MYC induces a dependence on the NUAK1 kinase, but the molecular mechanisms underlying this dependence have not been fully clarified.
Ade, C.P. +18 more
core +1 more source
Ion mobility-resolved phosphoproteomics with dia-PASEF and short gradients
bioRxiv, 2022 Mass spectrometry-based phosphoproteomics has identified >150,000 post-translational phosphorylation sites in the human proteome. To disentangle their functional relevance, complex experimental designs that require increased throughput are now coming ...
D. Oliinyk, F. Meier
semanticscholar +1 more source
Protein Phosphorylation Changes During Systemic Acquired Resistance in Arabidopsis thaliana
Frontiers in Plant Science, 2021 Systemic acquired resistance (SAR) in plants is a defense response that provides resistance against a wide range of pathogens at the whole-plant level following primary infection.
Qingfeng Zhou +7 more
doaj +1 more source
Frontiers in Plant Science, 2017 Mass spectrometry (MS)-based large scale phosphoproteomics has facilitated the investigation of plant phosphorylation dynamics on a system-wide scale. However, generating large scale data sets for membrane phosphoproteins usually requires fractionation ...
Xu Na Wu +5 more
doaj +1 more source
Proceedings of the EuBIC Winter School 2019 [PDF]
, 2019 The 2019 European Bioinformatics Community (EuBIC) Winter School was held from January 15th to January 18th 2019 in Zakopane, Poland. This year’s meeting was the third of its kind and gathered international researchers in the field of (computational ...
Bittremieux, Wout +9 more
core +4 more sources