Results 41 to 50 of about 14,675 (189)

Quantitative Phosphoproteomics Reveals the Requirement of DYRK1-Mediated Phosphorylation of Ion Transport- and Cell Junction-Related Proteins for Notochord Lumenogenesis in Ascidian

Cells, 2023
The dual-specificity tyrosine phosphorylation-regulated kinase (DYRK1) phosphorylates diverse substrates involved in various cellular processes. Here, we found that blocking the kinase activity of DYRK1 inhibited notochord development and lumenogenesis ...
Zhuqing Wang, Xiuke Ouyang, Zicheng Tan, Likun Yang, Bo Dong   +4 more
doaj   +1 more source

Proximal Phosphoproteomics Approaches revealed a FGFR-EGFR functional cross-talk

, 2021
We developed Proximal Phosphoproteomics Approaches (PPAs)to study RTK endocytosis-dependent proximal signaling in breast cancer ...
Francavilla, Chiara; id_orcid, Division of Molecular & Cellular Function (L5)   +1 more
core   +1 more source

Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors

Cell Reports, 2021
Summary: Macrophages undergoing M1- versus M2-type polarization differ significantly in their cell metabolism and cellular functions. Here, global quantitative time-course proteomics and phosphoproteomics paired with transcriptomics provide a ...
Lizhi He, Jhih-Hua Jhong, Qi Chen, Kai-Yao Huang, Karin Strittmatter, Johannes Kreuzer, Michael DeRan, Xu Wu, Tzong-Yi Lee, Nikolai Slavov, Wilhelm Haas, Alexander G. Marneros   +11 more
doaj   +1 more source

Quantitative phosphoproteomics to characterize signaling networks

, 2012
Reversible protein phosphorylation is involved in the regulation of most, if not all, major cellular processes via dynamic signal transduction pathways. During the last decade quantitative phosphoproteomics have evolved from a highly specialized area to ...
Blagoev, Blagoy; id_orcid, Blagoev, Blagoy, Rigbolt, Kristoffer T G, Rigbolt, Kristoffer T. G.   +3 more
core   +1 more source

Phosphoproteomics results of GntR in WT SS2 and Δstk.

, 2023
Phosphoproteomics results of GntR in WT SS2 and Δstk.
Huixing Lin (4033031), Hong Zhou (29614), Mingxing Liu (141843), Kai Niu (818117), Hongjie Fan (167764), Zhe Ma (167751), Yu Meng (152553)   +6 more
core   +1 more source

Computational Analysis of Phosphoproteomics: Progresses and Perspectives

, 2020
: Phosphorylation is one of the most essential post-translational modifications (PTMs) of proteins, regulates a variety of cellular signaling pathways, and at least partially determines the biological diversity.
Qian Ma, Zexian Liu, Jun Cao, Yu Xue, Jian Ren, Xinjiao Gao   +5 more
core   +1 more source

Metformin inhibits the proliferation of hepatocellular carcinoma cells through inducing ferroptosis analyzed by phosphoproteomics

Frontiers in Oncology
IntroductionThis study aims to investigate the effects of Metformin on hepatocellular carcinoma cell lines, cell lines and explores the molecular mechanisms underlying.MethodsBel-7402 and HepG2 cells were treated with varying concentrations of Metformin ...
Jihan Sun, Jihan Sun, Xi Yu, Yuying Shan, Manyun Dai, Andrea Gaucherot, Caide Lu, Shuqi Mao   +7 more
doaj   +1 more source

Personalized phosphoproteomics identifies functional signaling

, 2021
Protein phosphorylation dynamically integrates environmental and cellular information to control biological processes. Identifying functional phosphorylation amongst the thousands of phosphosites regulated by a perturbation at a global scale is a major ...
Petersen, Janni, Pehmøller, Christian, James, David E, Kristensen, Jonas Møller, Onslev, Johan, Ling, Naomi X Y, Hingst, Janne Rasmuss, Hingst, Janne R., Parker, Benjamin L, Onslev, Johan Dejgaard, Oakhill, Jonathan S, Needham, Elise J., Kristensen, Jonas M., Kiens, Bente, Morrison, Kaitlin R, Ling, Naomi X.Y., Humphrey, Sean J., Morrison, Kaitlin R., Needham, Elise J, Wojtaszewski, Jørgen F.P., Højlund, Kurt, James, David E., Wojtaszewski, Jørgen, Yang, Guang, Humphrey, Sean J, Richter, Erik A., Oakhill, Jonathan S., Parker, Benjamin L., Erik A. Richter, Naomi X. Y. Ling, Bente Kiens, Janne R. Hingst, Kurt Højlund, Jørgen F. P. Wojtaszewski, Jonathan S. Oakhill, Guang Yang, Sean J. Humphrey, Elise J. Needham, Benjamin L. Parker, Janni Petersen, Kaitlin R. Morrison, Jonas M. Kristensen, Johan Onslev, Christian Pehmøller, David E. James   +44 more
core   +1 more source

A Phosphoproteomics Study of the Soybean root necrosis 1 Mutant Revealed Type II Metacaspases Involved in Cell Death Pathway

Frontiers in Plant Science, 2022
The soybean root necrosis 1 (rn1) mutation causes progressive browning of the roots soon after germination and provides increased tolerance to the soil-borne oomycete pathogen Phytophthora sojae in soybean. Toward understanding the molecular basis of the
Feifei Wang, Priyanka Das, Narinder Pal, Ruchika Bhawal, Sheng Zhang, Madan K. Bhattacharyya   +5 more
doaj   +1 more source

Phosphoproteomics and interactomics reveal novel regulatory mechanisms of plant aquaporins

, 2016
Phosphoproteomics and interactomics reveal novel regulatory mechanisms of plant aquaporins.
Di Pietro, Magali, Maurel, Christophe, Prado, Karine, Santoni, Veronique, Hem, Sonia, Champeyroux, Chloé, Rofidal, Valerie, Bellati, Jorge   +7 more
core   +3 more sources