Results 61 to 70 of about 14,675 (189)

Effect of Praziquantel on Schistosoma mekongi Proteome and Phosphoproteome

Pathogens, 2020
Schistosoma mekongi causes schistosomiasis in southeast Asia, against which praziquantel (PZQ) is the only treatment option. PZQ resistance has been reported, thus increasing the requirement to understand mechanism of PZQ.
Peerut Chienwichai, Sumate Ampawong, Poom Adisakwattana, Tipparat Thiangtrongjit, Yanin Limpanont, Phiraphol Chusongsang, Yupa Chusongsang, Onrapak Reamtong   +7 more
doaj   +1 more source

A Selective MAP3K1 Inhibitor Facilitates Discovery of NPM1 as a Member of the Network

Molecules
The quinoxaline core is found in several biologically active compounds, with Erdafitinib being the first FDA-approved quinoxaline derivative that targets a kinase and exhibits anti-cancer properties.
Lidia Boghean, Sarbjit Singh, Kiran K. Mangalaparthi, Smitha Kizhake, Lelisse Umeta, Donn Wishka, Paul Grothaus, Akhilesh Pandey, Amarnath Natarajan   +8 more
doaj   +1 more source

Phosphoproteomics-based systems analysis of signal transduction networks

Frontiers in Physiology, 2012
Signal transduction systems coordinate complex cellular information to regulate biological events such as cell proliferation and differentiation. Although the accumulating evidence on widespread association of signaling molecules has revealed essential ...
Hiroko eKozuka-Hata, Shinya eTasaki, Masaaki eOyama   +2 more
doaj   +1 more source

Goals and Challenges in Bacterial Phosphoproteomics [PDF]

International Journal of Molecular Sciences, 2019
Reversible protein phosphorylation at serine, threonine and tyrosine is a well-known dynamic post-translational modification with stunning regulatory and signalling functions in eukaryotes. Shotgun phosphoproteomic analyses revealed that this post-translational modification is dramatically lower in bacteria than in eukaryotes.
Paula Yagüe, Nathaly Gonzalez-Quiñonez, Gemma Fernández-García, Sergio Alonso-Fernández, Angel Manteca   +4 more
openaire   +3 more sources

Proteomics and phosphoproteomics to study Tuina reverses capsule fibrosis in frozen shoulder: a research report based on rats

Scientific Reports
Frozen shoulder (FS) is a common disorder often treated with Tuina, but the mechanisms involved remain unclear. We employed proteomics and phosphoproteomics to investigate the mechanisms associated with the treatment of capsule fibrosis in FS rats.
Yingjie Qiao, Jianmin Wang, Lijun Zheng, Yanhong Yang, Huadong Li, Muzhen Li, Shidong Zhang, Hongyi Wang, Tiantian Zhang   +8 more
doaj   +1 more source

iProteinDB: An Integrative Database of Drosophila Post-translational Modifications

G3: Genes, Genomes, Genetics, 2019
Post-translational modification (PTM) serves as a regulatory mechanism for protein function, influencing their stability, interactions, activity and localization, and is critical in many signaling pathways.
Yanhui Hu, Richelle Sopko, Verena Chung, Marianna Foos, Romain A. Studer, Sean D. Landry, Daniel Liu, Leonard Rabinow, Florian Gnad, Pedro Beltrao, Norbert Perrimon   +10 more
doaj   +1 more source

Comparative Ser/Thr/Tyr phosphoproteomics between two Mycobacterial species: The fast growing Mycobacterium smegmatis and the slow growing Mycobacterium bovis BCG.

Frontiers in Microbiology, 2015
Ser/Thr/Tyr protein phosphorylation plays a critical role in regulating mycobacterial growth and development. Understanding the mechanistic link between protein phosphorylation signaling network and mycobacterial growth rate requires a global view of the
Kehilwe Confidence Nakedi, Andrew JM Nel, Shaun eGarnett, Jonathan M Blackburn, Nelson Da Cruz Soares   +4 more
doaj   +1 more source

Coactosin Phosphorylation Controls Entamoeba histolytica Cell Membrane Protrusions and Cell Motility

mBio, 2020
Invasion of the colon wall by Entamoeba histolytica during amoebic dysentery entails migration of trophozoites through tissue layers that are rich in extracellular matrix. Transcriptional silencing of the E.
Muhammad M. Hasan, José E. Teixeira, Ying-Wai Lam, Christopher D. Huston   +3 more
doaj   +1 more source

Sustained mitogen-activated protein kinase activation reprograms defense metabolism and phosphoprotein profile in Arabidopsis thaliana.

Frontiers in Plant Science, 2014
Mitogen-activated protein kinases (MAPKs) target a variety of protein substrates to regulate cellular signaling processes in eukaryotes. In plants, the number of identified MAPK substrates that control plant defense responses is still limited.
Ines eLassowskat, Christoph eBoettcher, Christoph eBoettcher, Lennart eEschen-Lippold, Dierk eScheel, Justin eLee   +5 more
doaj   +1 more source

Why phosphoproteomics is still a challenge [PDF]

, 2015
Despite continuous improvements phosphoproteomics still faces challenges that are often neglected, e.g. partially poor recovery of phosphopeptide enrichment, assessment of phosphorylation stoichiometry, label-free quantification, poor behavior during ...
Solari, Fiorella A., Dell'Aica, Margherita, Sickmann, Albert, Zahedi, René P.   +3 more
core   +1 more source