Results 61 to 70 of about 27,576 (286)
Phosphoproteomics of ATR signaling in mouse testes
eLife, 2022 The phosphatidylinositol 3′ kinase (PI3K)‐related kinase ATR is crucial for mammalian meiosis. ATR promotes meiotic progression by coordinating key events in DNA repair, meiotic sex chromosome inactivation (MSCI), and checkpoint-dependent quality control
Jennie R. Sims +10 more
semanticscholar +1 more source
Phosphoproteomics‐based network medicine [PDF]
The FEBS Journal, 2013 One of the major tasks of phosphoproteomics is providing potential biomarkers for either diagnosis or drug targets in medical applications. Because most complex diseases are due to the actions of multiple genes/proteins, the identification of complex phospho‐signatures containing multiple phosphorylation events within phosphoproteomics‐based networks ...
Zexian, Liu, Yongbo, Wang, Yu, Xue
openaire +2 more sources
Animals, 2022 Salmonella enterica serovar Enteritidis (S. Enteritidis) is a foodborne pathogen, which can cause great threats to human health through the consumption of contaminated poultry products.
Xiuxiu Miao +7 more
doaj +1 more source
An evolutionary perspective on the kinome of malaria parasites [PDF]
, 2012 Malaria parasites belong to an ancient lineage that diverged very early from the main branch of eukaryotes. The approximately 90-member plasmodial kinome includes a majority of eukaryotic protein kinases that clearly cluster within the AGC, CMGC, TKL ...
Andrew B. Tobin +6 more
core +1 more source
bioRxiv, 2022 Acute myeloid leukaemia (AML) patients harbouring certain chromosome abnormalities have particularly adverse prognosis. For these patients, targeted therapies have not yet made a significant clinical impact.
P. Casado +16 more
semanticscholar +1 more source
Phosphoproteomics taken to heart [PDF]
Cell Cycle, 2013 The last decade has witnessed a tremendous advance in mass spectrometric instrumentation, sample preparation, and computational proteomics developments that now make it possible to analyze proteins1 or post-translational modifications (PTMs) of proteins2 on a global scale and compare their relative abundance between different cell states.
Lundby, A., Olsen, J.V.
openaire +3 more sources
Neuronal Signaling Involved in Neuronal Polarization and Growth: Lipid Rafts and Phosphorylation
Frontiers in Molecular Neuroscience, 2020 Neuronal polarization and growth are developmental processes that occur during neuronal cell differentiation. The molecular signaling mechanisms involved in these events in in vivo mammalian brain remain unclear.
Michihiro Igarashi +3 more
doaj +1 more source
Cells, 2023 The dual-specificity tyrosine phosphorylation-regulated kinase (DYRK1) phosphorylates diverse substrates involved in various cellular processes. Here, we found that blocking the kinase activity of DYRK1 inhibited notochord development and lumenogenesis ...
Zhuqing Wang +4 more
doaj +1 more source
µPhos: a scalable and sensitive platform for high-dimensional phosphoproteomics
Molecular Systems BiologyMass spectrometry has revolutionized cell signaling research by vastly simplifying the analysis of many thousands of phosphorylation sites in the human proteome.
D. Oliinyk +12 more
semanticscholar +1 more source
Molecular Oncology, 2010 AbstractReversible protein phosphorylation serves as a basis for regulating a number of cellular processes. Aberrant activation of kinase signaling pathways is commonly associated with several cancers. Recent developments in phosphoprotein/phosphopeptide enrichment strategies and quantitative mass spectrometry have resulted in robust pipelines for high‐
H C, Harsha, Akhilesh, Pandey
openaire +3 more sources