Results 71 to 80 of about 27,576 (286)

Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors

Cell Reports, 2021
Summary: Macrophages undergoing M1- versus M2-type polarization differ significantly in their cell metabolism and cellular functions. Here, global quantitative time-course proteomics and phosphoproteomics paired with transcriptomics provide a ...
Lizhi He, Jhih-Hua Jhong, Qi Chen, Kai-Yao Huang, Karin Strittmatter, Johannes Kreuzer, Michael DeRan, Xu Wu, Tzong-Yi Lee, Nikolai Slavov, Wilhelm Haas, Alexander G. Marneros   +11 more
doaj   +1 more source

Inferring the Sign of Kinase-Substrate Interactions by Combining Quantitative Phosphoproteomics with a Literature-Based Mammalian Kinome Network

, 2010
Protein phosphorylation is a reversible post-translational modification commonly used by cell signaling networks to transmit information about the extracellular environment into intracellular organelles for the regulation of the activity and sorting of ...
Hernandez, Marylens, Lachmann, Alexander, Ma'ayan, Avi, Xiao, Kunhong, Zhao, Shan   +4 more
core   +1 more source

Large-scale phosphoproteomics reveals activation of the MAPK/GADD45β/P38 axis and cell cycle inhibition in response to BMP9 and BMP10 stimulation in endothelial cells

Cell Communication and Signaling
BMP9 and BMP10 are two major regulators of vascular homeostasis. These two ligands bind with high affinity to the endothelial type I kinase receptor ALK1, together with a type II receptor, leading to the direct phosphorylation of the SMAD transcription ...
M. Al Tarrass, L. Belmudes, D. Koça, Valentin Azemard, Hequn Liu, T. Al Tabosh, Delphine Ciais, A. Desroches-Castan, C. Battail, Y. Couté, C. Bouvard, S. Bailly   +11 more
semanticscholar   +1 more source

Phosphoproteomics data classify hematological cancer cell lines according to tumor type and sensitivity to kinase inhibitors [PDF]

, 2013
This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ...
Alcolea, MP, Casado, P, Cutillas, PR, Iorio, F, Joel, S, Rodriguez-Prados, J-C, Saez-Rodriguez, J, Vanhaesebroeck, B   +7 more
core   +5 more sources

Comprehensive analysis of the membrane phosphoproteome regulated by oligogalacturonides in Arabidopsis thaliana [PDF]

, 2016
Early changes in the Arabidopsis thaliana membrane phosphoproteome in response to oligogalacturonides (OGs), a class of plant damage-associated molecular patterns (DAMPs), were analyzed by two complementary proteomic approaches.
DE LORENZO, Giulia, MATTEI, Maria Benedetta, PONTIGGIA, Daniela, SPINELLI, FRANCESCO   +3 more
core   +1 more source

A Rapid One-Pot Workflow for Sensitive Microscale Phosphoproteomics

Journal of Proteome Research
Compared to advancements in single-cell proteomics, phosphoproteomics sensitivity has lagged behind due to low abundance, complex sample preparation, and substantial sample input requirements.
G. Muneer, Ciao-Syuan Chen, Tzu-Tsung Lee, Bojin Chen, Yu‐Ju Chen   +4 more
semanticscholar   +1 more source

A Phosphoproteomics Study of the Soybean root necrosis 1 Mutant Revealed Type II Metacaspases Involved in Cell Death Pathway

Frontiers in Plant Science, 2022
The soybean root necrosis 1 (rn1) mutation causes progressive browning of the roots soon after germination and provides increased tolerance to the soil-borne oomycete pathogen Phytophthora sojae in soybean. Toward understanding the molecular basis of the
Feifei Wang, Priyanka Das, Narinder Pal, Ruchika Bhawal, Sheng Zhang, Madan K. Bhattacharyya   +5 more
doaj   +1 more source

Investigating the effect of target of rapamycin kinase inhibition on the Chlamydomonas reinhardtii phosphoproteome: from known homologs to new targets [PDF]

, 2019
Recuperado de: https://www.biorxiv.org/content/10.1101/310102v1Target of rapamycin (TOR) kinase is a conserved regulator of cell growth whose activity is modulated in response to nutrients, energy and stress.
Couso Liáñez, Inmaculada Concepción, Crespo González, José Luis, Hicks, Leslie, McConnell, Evan W., Perrine, Zoee, Umen, James G., Werth, Emily G.   +6 more
core   +1 more source

Advancements in Global Phosphoproteomics Profiling: Overcoming Challenges in Sensitivity and Quantification

Proteomics
Protein phosphorylation introduces post‐genomic diversity to proteins, which plays a crucial role in various cellular activities. Elucidation of system‐wide signaling cascades requires high‐performance tools for precise identification and quantification ...
G. Muneer, Ciao-Syuan Chen, Yu‐Ju Chen
semanticscholar   +1 more source

Multiple Layers of Phospho-Regulation Coordinate Metabolism and the Cell Cycle in Budding Yeast

Frontiers in Cell and Developmental Biology, 2019
The coordination of metabolism and growth with cell division is crucial for proliferation. While it has long been known that cell metabolism regulates the cell division cycle, it is becoming increasingly clear that the cell division cycle also regulates ...
Lichao Zhang, Sebastian Winkler, Fabian P. Schlottmann, Oliver Kohlbacher, Oliver Kohlbacher, Oliver Kohlbacher, Oliver Kohlbacher, Oliver Kohlbacher, Josh E. Elias, Jan M. Skotheim, Jennifer C. Ewald   +10 more
doaj   +1 more source