Results 71 to 80 of about 12,949 (236)
, 2012 The book provides an overview of state-of-art techniques for the purification, analysis and quantification of proteins in complex samples using different enrichment strategies.
F. Lonardoni, BOSSI, Alessandra Maria
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Advanced Science, EarlyView.Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai +9 more
wiley +1 more source
Quantitative comparative phosphoproteomics to decipher signal transduction [PDF]
, 2016 Adaptation to changing environmental conditions takes place rapidly in all living organisms: cells must respond to a wide variety of signals. Through successive protein phosphorylation and de-phosphorylation steps, signal transduction cascades mediate ...
Davanture, Marlène +3 more
core +4 more sources
Toxins, 2016 Deoxynivalenol (DON) is a widespread trichothecene mycotoxin that commonly contaminates cereal crops and has various toxic effects in animals and humans.
Zhi-Qi Zhang +5 more
doaj +1 more source
Effect of Praziquantel on Schistosoma mekongi Proteome and Phosphoproteome
Pathogens, 2020 Schistosoma mekongi causes schistosomiasis in southeast Asia, against which praziquantel (PZQ) is the only treatment option. PZQ resistance has been reported, thus increasing the requirement to understand mechanism of PZQ.
Peerut Chienwichai +7 more
doaj +1 more source
Advanced Science, EarlyView.A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo +18 more
wiley +1 more source
A Selective MAP3K1 Inhibitor Facilitates Discovery of NPM1 as a Member of the Network
MoleculesThe quinoxaline core is found in several biologically active compounds, with Erdafitinib being the first FDA-approved quinoxaline derivative that targets a kinase and exhibits anti-cancer properties.
Lidia Boghean +8 more
doaj +1 more source
Phosphoproteomics-based systems analysis of signal transduction networks
Frontiers in Physiology, 2012 Signal transduction systems coordinate complex cellular information to regulate biological events such as cell proliferation and differentiation. Although the accumulating evidence on widespread association of signaling molecules has revealed essential ...
Hiroko eKozuka-Hata +2 more
doaj +1 more source
Goals and Challenges in Bacterial Phosphoproteomics [PDF]
International Journal of Molecular Sciences, 2019 Reversible protein phosphorylation at serine, threonine and tyrosine is a well-known dynamic post-translational modification with stunning regulatory and signalling functions in eukaryotes. Shotgun phosphoproteomic analyses revealed that this post-translational modification is dramatically lower in bacteria than in eukaryotes.
Paula Yagüe +4 more
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Advanced Science, EarlyView.An in situ‐grown BP‐CaO2 nanoplatform supplies coordinated Ca2+, endogenous phosphate, and oxidative stress to convert tumor calcification from a passive endpoint into an active immune‐remodeling process. Widespread hydroxyapatite deposition is visualized by CT, while multi‐omics reveals MCOLN2 as a calcium‐responsive mediator linking biomineralization
Long Liu +11 more
wiley +1 more source