Results 51 to 60 of about 14,144 (239)

Phosphoproteomics Profile of Chicken Cecum in the Response to Salmonella enterica Serovar Enteritidis Inoculation

Animals, 2022
Salmonella enterica serovar Enteritidis (S. Enteritidis) is a foodborne pathogen, which can cause great threats to human health through the consumption of contaminated poultry products.
Xiuxiu Miao, Ya’nan Zhao, Huilong Li, Yanru Ren, Geng Hu, Jingchao Yang, Liying Liu, Xianyao Li   +7 more
doaj   +1 more source

Neuronal Signaling Involved in Neuronal Polarization and Growth: Lipid Rafts and Phosphorylation

Frontiers in Molecular Neuroscience, 2020
Neuronal polarization and growth are developmental processes that occur during neuronal cell differentiation. The molecular signaling mechanisms involved in these events in in vivo mammalian brain remain unclear.
Michihiro Igarashi, Atsuko Honda, Asami Kawasaki, Motohiro Nozumi   +3 more
doaj   +1 more source

Quantitative Phosphoproteomics Reveals the Requirement of DYRK1-Mediated Phosphorylation of Ion Transport- and Cell Junction-Related Proteins for Notochord Lumenogenesis in Ascidian

Cells, 2023
The dual-specificity tyrosine phosphorylation-regulated kinase (DYRK1) phosphorylates diverse substrates involved in various cellular processes. Here, we found that blocking the kinase activity of DYRK1 inhibited notochord development and lumenogenesis ...
Zhuqing Wang, Xiuke Ouyang, Zicheng Tan, Likun Yang, Bo Dong   +4 more
doaj   +1 more source

Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors

Cell Reports, 2021
Summary: Macrophages undergoing M1- versus M2-type polarization differ significantly in their cell metabolism and cellular functions. Here, global quantitative time-course proteomics and phosphoproteomics paired with transcriptomics provide a ...
Lizhi He, Jhih-Hua Jhong, Qi Chen, Kai-Yao Huang, Karin Strittmatter, Johannes Kreuzer, Michael DeRan, Xu Wu, Tzong-Yi Lee, Nikolai Slavov, Wilhelm Haas, Alexander G. Marneros   +11 more
doaj   +1 more source

Metformin inhibits the proliferation of hepatocellular carcinoma cells through inducing ferroptosis analyzed by phosphoproteomics

Frontiers in Oncology
IntroductionThis study aims to investigate the effects of Metformin on hepatocellular carcinoma cell lines, cell lines and explores the molecular mechanisms underlying.MethodsBel-7402 and HepG2 cells were treated with varying concentrations of Metformin ...
Jihan Sun, Jihan Sun, Xi Yu, Yuying Shan, Manyun Dai, Andrea Gaucherot, Caide Lu, Shuqi Mao   +7 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

A Phosphoproteomics Study of the Soybean root necrosis 1 Mutant Revealed Type II Metacaspases Involved in Cell Death Pathway

Frontiers in Plant Science, 2022
The soybean root necrosis 1 (rn1) mutation causes progressive browning of the roots soon after germination and provides increased tolerance to the soil-borne oomycete pathogen Phytophthora sojae in soybean. Toward understanding the molecular basis of the
Feifei Wang, Priyanka Das, Narinder Pal, Ruchika Bhawal, Sheng Zhang, Madan K. Bhattacharyya   +5 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes [Dataset]

, 2023
Acute myeloid leukemia (AML) is a disease with poor outcome but patients harbouring certain chromosomal rearrangements or complex karyotypes have particularly adverse prognosis.
Gribben, John G., Taussig, David C., Río-Machín, Ana, Cutillas, Pedro, Rouault-Pierre, Kevin, Bödör, Csaba, Casado, Pedro, Miettinen, Juho J., Parsons, Alun, Rajeeve, Vinothini, Bewicke-Copley, Findlay, Heckman, Caroline, Fitzgibbon, Jude, Miraki-Moud, Farideh, Krizsan, Szilvia   +14 more
core   +1 more source

Multiple Layers of Phospho-Regulation Coordinate Metabolism and the Cell Cycle in Budding Yeast

Frontiers in Cell and Developmental Biology, 2019
The coordination of metabolism and growth with cell division is crucial for proliferation. While it has long been known that cell metabolism regulates the cell division cycle, it is becoming increasingly clear that the cell division cycle also regulates ...
Lichao Zhang, Sebastian Winkler, Fabian P. Schlottmann, Oliver Kohlbacher, Oliver Kohlbacher, Oliver Kohlbacher, Oliver Kohlbacher, Oliver Kohlbacher, Josh E. Elias, Jan M. Skotheim, Jennifer C. Ewald   +10 more
doaj   +1 more source