Results 31 to 40 of about 27,576 (286)

Knowledge-Based Analysis for Detecting Key Signaling Events from Time-Series Phosphoproteomics Data.

PLoS Computational Biology, 2015
Cell signaling underlies transcription/epigenetic control of a vast majority of cell-fate decisions. A key goal in cell signaling studies is to identify the set of kinases that underlie key signaling events.
Pengyi Yang, Xiaofeng Zheng, Vivek Jayaswal, Guang Hu, Jean Yee Hwa Yang, Raja Jothi   +5 more
doaj   +1 more source

Phosphoproteomics Screen Reveals Akt Isoform-Specific Signals Linking RNA Processing to Lung Cancer [PDF]

, 2014
The three Akt isoforms are functionally distinct. Here we show that their phosphoproteomes also differ, suggesting that their functional differences are due to differences in target specificity.
Ailan Guo, Bild, Cai, Carstens, Carvalho, Chen, Chen, Cho, Christos Polytarchou, Conrad, Cooper, Dimitrios Iliopoulos, Duina, Ezell, Filippos Kottakis, Franke, Gowher, Iliopoulos, Ioannis Sanidas, Jianxin Xie, Kalsotra, Kolasinska-Zwierz, Kottakis, Krogan, Kumar, Lan Hu, Luco, Luco, Manning, Maria Hatziapostolou, Maroulakou, Michael J. Comb, Miki, Moore, Moshkin, Orr-Urtreger, Peña, Philip N. Tsichlis, Polytarchou, Scott A. Ezell, Thiery, Tschopp, Wan, Wang, Warzecha, Xie, Yoh, Yoh, Zhang, Zhou   +49 more
core   +1 more source

Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance

bioRxiv, 2022
The failure of metabolic tissues to appropriately respond to insulin (“insulin resistance”) is an early marker in the pathogenesis of type 2 diabetes.
D. Fazakerley, Julian van Gerwen, Kristen C Cooke, Xiaowen Duan, E. Needham, Søren Madsen, Dougall M. Norris, A. S. Shun-Shion, J. Krycer, J. Burchfield, Pengyi Yang, M. Wade, J. Brozinick, David E. James, Sean J. Humphrey   +14 more
semanticscholar   +1 more source

Lighting Up T Lymphocyte Signaling with Quantitative Phosphoproteomics

Frontiers in Immunology, 2017
Phosphorylation is the most abundant post-translational modification, regulating several aspects of protein and cell function. Quantitative phosphoproteomics approaches have expanded the scope of phosphorylation analysis enabling the quantification of ...
Candelas Álvarez-Salamero, Candelas Álvarez-Salamero, Raquel Castillo-González, María N. Navarro, María N. Navarro, María N. Navarro   +5 more
doaj   +1 more source

Identification of Arginine Phosphorylation in Mycolicibacterium smegmatis

Microbiology Spectrum, 2022
Tuberculosis is a leading cause of worldwide infectious mortality. The prevalence of multidrug-resistant Mycobacterium tuberculosis infections drives an urgent need to exploit new drug targets.
Emmanuel C. Ogbonna, Henry R. Anderson, Karl R. Schmitz   +2 more
doaj   +1 more source

Applications and prospects of phosphoproteomics in renal disease research [PDF]

PeerJ
Introduction Phosphoproteomics, an advanced branch of molecular biology, utilizes specific techniques such as mass spectrometry, affinity chromatography, and bioinformatics analysis to explore protein phosphorylation, shedding light on the cellular ...
XueJia Zheng, LingLing Zhou, TianTian Xu, GuoYing Wang, YaLi Peng, ChunMei Wen, MengYao Wu, HuiHui Tao, Yong Dai   +8 more
doaj   +2 more sources

Phosphorylation-Mediated Molecular Pathway Changes in Human Pituitary Neuroendocrine Tumors Identified by Quantitative Phosphoproteomics

Cells, 2021
To investigate the biological role of protein phosphorylation in human nonfunctional pituitary neuroendocrine tumors (NF-PitNETs), proteins extracted from NF-PitNET and control tissues were analyzed with tandem mass tag (TMT)-based quantitative ...
Jiajia Li, Siqi Wen, Biao Li, Na Li, Xianquan Zhan   +4 more
doaj   +1 more source

Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment. [PDF]

, 2018
The myeloma bone marrow microenvironment promotes proliferation of malignant plasma cells and resistance to therapy. Activation of JAK/STAT signaling is thought to be a central component of these microenvironment-induced phenotypes.
Aftab, Blake T, Ferguson, Ian D, Hann, Byron C, Lam, Christine, Lin, Yu-Hsiu T, Liu, Hui, Liu, Jun O, Mariano, Margarette C, Mitsiades, Constantine S, Murnane, Megan, Smith, Geoffrey A, Taunton, Jack, Wiita, Arun P, Wong, Sandy W   +13 more
core   +2 more sources

Temporal Quantitative Phosphoproteomics Profiling of Interleukin-33 Signaling Network Reveals Unique Modulators of Monocyte Activation

Cells, 2022
Interleukin-33 (IL-33), a member of the IL-1 superfamily cytokines, is an endogenous danger signal and a nuclear-associated cytokine. It is one of the essential mediators of both innate and adaptive immune responses.
Devasahayam Arokia Balaya Rex, Yashwanth Subbannayya, Prashant Kumar Modi, Akhina Palollathil, Lathika Gopalakrishnan, Yashodhar P. Bhandary, Thottethodi Subrahmanya Keshava Prasad, Sneha M. Pinto   +7 more
doaj   +1 more source

Optimal analytical strategies for sensitive and quantitative phosphoproteomics using TMT‐based multiplexing

Proteomics, 2022
In large‐scale quantitative mass spectrometry (MS)‐based phosphoproteomics, isobaric labeling with tandem mass tags (TMTs) coupled with offline high‐pH reversed‐phase peptide chromatographic fractionation maximizes depth of coverage.
Claire Koenig, Ana Martínez-Val, G. Franciosa, J. Olsen   +3 more
semanticscholar   +1 more source