Results 81 to 90 of about 14,675 (189)
Phosphoproteomics and Lung Cancer Research
, 2012 Massive evidence suggests that genetic abnormalities contribute to the development of lung cancer. These molecular abnormalities may serve as diagnostic, prognostic and predictive biomarkers for this deadly disease.
William C. S. Cho, Elena López
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Designing experiments to discriminate families of logic models
Frontiers in Bioengineering and Biotechnology, 2015 Logic models of signaling pathways are a promising way of building effective in silico functional models of a cell, in particular of signaling pathways.
Santiago eVidela +10 more
doaj +1 more source
Towards single-cell LC-MS phosphoproteomics
, 2014 Protein phosphorylation is a ubiquitous posttranslational modification, which is heavily involved in signal transduction. Misregulation of protein phosphorylation is often associated with a decrease in cell viability and complex diseases such as cancer ...
Polat, Ayşe Nur; Özlü, Nurhan +2 more
core +1 more source
Personalised phosphoproteomics of skeletal muscle metabolism
, 2022 Protein phosphorylation dynamically integrates environmental and intracellular information to control virtually all biological processes. Challenges in determining the upstream regulation and downstream effects of phosphorylation obscures our functional ...
Needham, Elise
core
Phosphoproteomics and ubiquitinomics data-independent acquisition (DIA) mass spectrometry (MS) data is typically analyzed by using a data-dependent acquisition (DDA) spectral library.
Xiang-Yu Chen (2226904) +10 more
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SPIKE-IN ENHANCED PHOSPHOPROTEOMICS UNCOVERS SYNERGISTIC SIGNALING RESPONSES TO MEK INHIBITION IN COLORECTAL CANCER CELLS Spike-in enhanced phosphoproteomics uncovers synergistic signaling responses to MEK inhibition in colorectal cancer cells / van ...
van Bentum, Mirjam
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Parallel phosphoproteomics and metabolomics map the global metabolic tyrosine phosphoproteome
Proceedings of the National Academy of SciencesAbstract Tyrosine phosphorylation of metabolic enzymes is an evolutionarily conserved post-translational modification that facilitates rapid and reversible modulation of enzyme activity, localization or function. Despite the high abundance of tyrosine phosphorylation events detected on metabolic enzymes in high-throughput mass ...
Alissandra L. Hillis +8 more
openaire +2 more sources
Impact of phosphoproteomics in the translation of kinase‐targeted therapies
, 2017 [EN]Signaling pathways driven by protein and lipid kinases are altered in most human diseases. Therefore, pharmacological inhibitors of cell signaling are one of the most intensively pursued therapeutic approaches for the treatment of diseases such as ...
David Britton +7 more
core +1 more source
Integrative Proteomics and Phosphoproteomics Profiling of Symptomatic Accessory Navicular Bone Based on Tandem Mass Tag Technology [PDF]
Bin Liu,* Ran Wei,* Yuqing Wang, Zishen Cheng, Liangliang Jiang, Xiaopeng Pu, Yaxing Zhang, Yantao Wang, Qiangjun Kang Department of Orthopaedics, Bethune International Peace Hospital, Shijiazhuang, 050082, China*These authors contributed ...
Jiang L +7 more
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