Results 101 to 110 of about 27,576 (286)

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

E. coli Toxin YjjJ (HipH) Is a Ser/Thr Protein Kinase That Impacts Cell Division, Carbon Metabolism, and Ribosome Assembly

mSystems, 2023
Protein Ser/Thr kinases are posttranslational regulators of key molecular processes in bacteria, such as cell division and antibiotic tolerance. Here, we characterize the E.
Fabio Lino Gratani, Till Englert, Payal Nashier, Peter Sass, Laura Czech, Niels Neumann, Sofia Doello, Petra Mann, Rudolf Blobelt, Siegfried Alberti, Karl Forchhammer, Gert Bange, Katharina Höfer, Boris Macek   +13 more
doaj   +1 more source

SILAC-based phosphoproteomics reveals an inhibitory role of KSR1 in p53 transcriptional activity via modulation of DBC1 [PDF]

, 2013
BACKGROUND We have previously identified kinase suppressor of ras-1 (KSR1) as a potential regulatory gene in breast cancer. KSR1, originally described as a novel protein kinase, has a role in activation of mitogen-activated protein kinases.
A Filipovic, AA Adjei, AJ Levine, B Vogelstein, C-Y Koo, CH Shen, CL Brooks, D Zhang, DP Xirodimas, DR Rhodes, F De Amicis, F Vikhanskaya, G Giamas, G Giamas, H Mi, H Vaziri, H Zhang, H Zhang, HR Xing, J Cox, J Cox, J Hu, J Lozano, J Stebbing, J Yuan, JA Goettel, JE Kim, JR Wisniewski, K Kornfeld, L C Lit, L Zannini, M Therrien, M Therrien, M Zafrullah, MN Laurent, R Brough, R Fujita, R Kolesnick, RL Kortum, S Matsuoka, T Rajakulendran, TE Thingholm, V Nin, W Zhao, WM Abida, Y Tang, Y Xu, Y Zhang   +47 more
core   +2 more sources

Sustainable Phosphorylated Cellulose Nanocrystals: A Dual‐Affinity Platform for High‐Efficiency Enrichment of Intact Glycopeptides and Phosphopeptides

Advanced Science, EarlyView.
AAA ABSTRACT Protein glycosylation and phosphorylation are critical post‐translational modifications (PTMs) governing nearly all cellular functions, yet their analysis remains challenging due to reliance on costly and unsustainable enrichment materials.
Jiaying Li, Wuming Fan, Xuyang Yue, Dongdong Wang, Xiangyu Tang, Zhuo Zhang, Yonggui Wang, Yanjun Xie, Mingliang Ye, Hongqiang Qin   +9 more
wiley   +1 more source

Phosphoproteome Analysis Reveals the Molecular Mechanisms Underlying Deoxynivalenol-Induced Intestinal Toxicity in IPEC-J2 Cells

Toxins, 2016
Deoxynivalenol (DON) is a widespread trichothecene mycotoxin that commonly contaminates cereal crops and has various toxic effects in animals and humans.
Zhi-Qi Zhang, Song-Bo Wang, Rui-Guo Wang, Wei Zhang, Pei-Long Wang, Xiao-Ou Su   +5 more
doaj   +1 more source

Effect of Praziquantel on Schistosoma mekongi Proteome and Phosphoproteome

Pathogens, 2020
Schistosoma mekongi causes schistosomiasis in southeast Asia, against which praziquantel (PZQ) is the only treatment option. PZQ resistance has been reported, thus increasing the requirement to understand mechanism of PZQ.
Peerut Chienwichai, Sumate Ampawong, Poom Adisakwattana, Tipparat Thiangtrongjit, Yanin Limpanont, Phiraphol Chusongsang, Yupa Chusongsang, Onrapak Reamtong   +7 more
doaj   +1 more source

Global Phosphoproteomics Reveal CDK Suppression as a Vulnerability to KRas Addiction in Pancreatic Cancer

Clinical Cancer Research, 2021
Purpose: Among human cancers that harbor mutant (mt) KRas, some, but not all, are dependent on mt KRas. However, little is known about what drives KRas dependency.
Aslamuzzaman Kazi, Liwei Chen, Shengyan Xiang, R. Vangipurapu, Huan Yang, F. Beato, B. Fang, T. Williams, K. Husain, Patrick W. Underwood, J. Fleming, M. Malafa, E. Welsh, J. Koomen, J. Trevino, S. Sebti   +15 more
semanticscholar   +1 more source

Complex Genetic Architecture in RASopathies: Constitutional PTPN11 and Mosaic RIT1 Pathogenic Variants Underlying Severe Noonan Syndrome With Adult‐Onset Acute Myeloid Leukemia

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Noonan syndrome (NS) is a genetically heterogeneous disorder characterized by a broad spectrum of clinical features resulting from dysregulation of the RAS/MAPK pathway. Although complex genotypes are increasingly recognized in NS, cases harboring two distinct pathogenic variants in different NS genes remain extremely rare.
Francesco Prevedello, Dario Seif Ali, Chiara Piccolo, Chiara Rigon, Monica Forzan, Elena Tacchetto, Roberta Palmitessa, Davide Calosci, Leonardo Salviati, Carmela Gurrieri, Eva Trevisson   +10 more
wiley   +1 more source

Proteomics and phosphoproteomics to study Tuina reverses capsule fibrosis in frozen shoulder: a research report based on rats

Scientific Reports
Frozen shoulder (FS) is a common disorder often treated with Tuina, but the mechanisms involved remain unclear. We employed proteomics and phosphoproteomics to investigate the mechanisms associated with the treatment of capsule fibrosis in FS rats.
Yingjie Qiao, Jianmin Wang, Lijun Zheng, Yanhong Yang, Huadong Li, Muzhen Li, Shidong Zhang, Hongyi Wang, Tiantian Zhang   +8 more
doaj   +1 more source

A Selective MAP3K1 Inhibitor Facilitates Discovery of NPM1 as a Member of the Network

Molecules
The quinoxaline core is found in several biologically active compounds, with Erdafitinib being the first FDA-approved quinoxaline derivative that targets a kinase and exhibits anti-cancer properties.
Lidia Boghean, Sarbjit Singh, Kiran K. Mangalaparthi, Smitha Kizhake, Lelisse Umeta, Donn Wishka, Paul Grothaus, Akhilesh Pandey, Amarnath Natarajan   +8 more
doaj   +1 more source