Results 101 to 110 of about 14,144 (239)
Phosphoproteomics and Lung Cancer Research
, 2012 Massive evidence suggests that genetic abnormalities contribute to the development of lung cancer. These molecular abnormalities may serve as diagnostic, prognostic and predictive biomarkers for this deadly disease.
William C. S. Cho, Elena López
core +1 more source
Plant, Cell &Environment, EarlyView.ABSTRACT Molecular chaperones play a central role in the plant proteostasis machinery by aiding the folding of nascent proteins, preventing aggregation, and repairing or degrading damaged proteins. These functions are especially essential during abiotic and biotic stress, which can destabilise cellular proteins and disrupt metabolic homoeostasis.
Mingfang Yang +10 more
wiley +1 more source
Toward a Systems-Level View of Dynamic Phosphorylation Networks
Frontiers in Genetics, 2014 To better understand how cells sense and respond to their environment, it is important to understand the organization and regulation of the phosphorylation networks that underlie most cellular signal transduction pathways.
Robert Howard Newman +6 more
doaj +1 more source
Focus on Phosphoproteomics [PDF]
ELECTROPHORESIS, 2014 Carol, Nilsson +2 more
openaire +2 more sources
Plant, Cell &Environment, EarlyView.ABSTRACT Isoprene is the most abundant biogenic volatile organic compound emitted by terrestrial vegetation. Here we report the impact of isoprene on root‐associated microbiomes. Using isoprene‐emitting (IE) transgenic tobacco and isogenic non‐emitting (NE) controls, we performed co‐cultivation experiments in natural soil and analysed plant phenotypes ...
Manuel Bellucci +9 more
wiley +1 more source
Designing experiments to discriminate families of logic models
Frontiers in Bioengineering and Biotechnology, 2015 Logic models of signaling pathways are a promising way of building effective in silico functional models of a cell, in particular of signaling pathways.
Santiago eVidela +10 more
doaj +1 more source
Understanding extracellular vesicles in antiaging
Periodontology 2000, EarlyView.Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad +3 more
wiley +1 more source
Experimental Physiology, EarlyView.Abstract Ageing is associated with loss of skeletal muscle mass and strength (sarcopenia) and disrupted redox homeostasis. Redox signalling is essential for muscle adaptation, yet the mechanisms by which ageing disrupts cysteine‐based regulation are poorly defined. The drivers of site‐specific reactivity and signalling specificity in aged muscle remain
Ufuk Ersoy, Malcolm J. Jackson
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend In healthy young males, we found that skeletal muscle hypertrophy following a period of resistance exercise training (RET) was consistent within and between subjects, as assessed using a variety of established methods. The skeletal muscle hypertrophic response was independent of external load.
Matthew J. Lees +11 more
wiley +1 more source
Proximal Phosphoproteomics Approaches revealed a FGFR-EGFR functional cross-talk
, 2021 We developed Proximal Phosphoproteomics Approaches (PPAs)to study RTK endocytosis-dependent proximal signaling in breast cancer ...
Francavilla, Chiara; id_orcid +1 more
core +1 more source