Results 121 to 130 of about 14,144 (239)

Relaxin‐2: Shaping the Proteomic Landscape of Skeletal Muscle Physiology, Glucose Trafficking, and Mitochondrial Function in Rat

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Cardioprotective hormone relaxin‐2 showed relevant effects on rat skeletal muscle by altering proteins linked to muscle function, regeneration, differentiation, mitochondrial function, glucose metabolism, and structural integrity and organization. Specifically, relaxin‐2 reduced the expression of 95 proteins, increased 32, and elicited unique proteins ...
Xocas Vázquez‐Abuín, Lucía Gómez‐Cibeira, Javier García‐Seara, Pablo de la Fuente‐López, Carlos Minguito‐Carazo, Susana B. Bravo, Manuel Otero‐Santiago, Oreste Gualillo, José Ramón González‐Juanatey, Francisca Lago, Sandra Feijóo‐Bandín, Alana Aragón‐Herrera   +11 more
wiley   +1 more source

An Integrated Proteomics and Genomics Approach to Identify Essential Protein Kinases During Human Trophoblast Development

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Integrated quantitative proteomic, phosphoproteomic, and transcriptomic analyses of human trophoblast stem cells identify stage‐specific kinase signaling networks that regulate trophoblast self‐renewal and differentiation into syncytiotrophoblasts and extravillous trophoblasts.
Rajnish Kumar, Purbasa Dasgupta, Soma Ray, Soumen Paul   +3 more
wiley   +1 more source

How Epitranscriptomic Machinery Senses Environmental Cues

Advanced Biology, Volume 10, Issue 9, September 2026.
Exogenous exposures, microenvironmental signals, and intracellular metabolic or redox states can alter RNA‐modification machinery through catalytic chemistry, signaling‐dependent PTMs, compartmental redistribution, or changes in abundance and composition.
Shayan Jalali, Ehsan Pashay Ahi
wiley   +1 more source

Parallel phosphoproteomics and metabolomics map the global metabolic tyrosine phosphoproteome

Proceedings of the National Academy of Sciences
Abstract Tyrosine phosphorylation of metabolic enzymes is an evolutionarily conserved post-translational modification that facilitates rapid and reversible modulation of enzyme activity, localization or function. Despite the high abundance of tyrosine phosphorylation events detected on metabolic enzymes in high-throughput mass ...
Alissandra L. Hillis, Tigist Tamir, Grace E. Perry, John M. Asara, Jared L. Johnson, Tomer M. Yaron, Lewis C. Cantley, Forest M. White, Alex Toker   +8 more
openaire   +2 more sources

Metal Ions in Longgu (Fossilized Bone) as a Natural Synergistic Network for Multi‐Target Therapy in Psychiatric Disorders

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Longgu (fossilized bone) delivers a natural synergistic network of metal ions, Ca2+, Mg2+, Zn2+, Fe, Cu, and Mn2+ that collectively targets the interconnected pathologies of anxiety, depression, and insomnia. This multi‐ion system operates through coordinated mechanisms including ionostatic balance, cross‐pathway synergy, and systemic integration ...
Sun Xiujia, Li Zhan Hua, Gao Yuanze, Liu Jing, Li Li, Zhang Chao, Kumar Ganesan, Jianping Chen   +7 more
wiley   +1 more source

Oligodendrocyte‐Targeted SGK1.1 Inhibition Alleviates White Matter Injury and Cognitive Impairment in Alzheimer's Disease via Modulation of HDAC2 Phosphorylation

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
We found an early Sgk1.1 mRNA upregulation within oligodendrocyte‐lineage cells of 5 × FAD mice, implicating SGK1.1 signaling as an early driver of myelin pathology. Mechanistically, SGK1.1 promotes HDAC2 phosphorylation at S422/S424, thereby impairing oligodendrocyte maturation.
Shiji Deng, Shenghan Gao, Chao Zhou, Zhen Lan, Huiya Li, Jiang Chen, Yuhao Xu, Jiashuo Li, Pinyi Liu, Siyuan Zhang, Xinyu Bao, Tingting Wang, Yun Xu, Xiaolei Zhu   +13 more
wiley   +1 more source

Phosphoester Bond Stabilization for Enhanced CID Phosphoproteomics

, 2013
Proteomics uses highly sensitive mass spectrometers to measure peptide fragment masses from enzymatically digested proteins. Measuring the mass of the peptide and fragments produced in the mass spectrometer allows for identification of its parent protein.
Morley, Stewart, Prince, Dr. John
core  

Understanding the Epigenetic Landscape of Barrett's Esophagus and Esophageal Cancer: A Review of Current Findings, Caveats and Future Directions

Genes, Chromosomes and Cancer, Volume 65, Issue 9, September 2026.
ABSTRACT Esophageal cancer (OC) is currently the eighth most common form of cancer worldwide with a 5‐year survival rate of 10%–20%, with the primary risk factor of esophageal adenocarcinoma (OAC) being the development of Barrett's Esophagus (BO).
Louise Lawless, Trevor Doherty, Carla Surlis, Niamh Gilmartin, Therese M. Murphy   +4 more
wiley   +1 more source

Pharmacological Inhibition of Small Extracellular Vesicle Secretion by ALK5i SD‐208 via Lysosomal Rerouting of CD63+ Compartments

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
ABSTRACT Pharmacological tools to selectively modulate extracellular vesicle (EV) secretion are scarce. Here, we identify the ALK5 (TGF‐β receptor I) inhibitor SD‐208 as a potent suppressor of small EV (sEV) secretion that acts independently of its canonical anti‐fibrotic activity.
Rahul Sanwlani, Georgina H. Thompson, Kyle Bramich, Ching‐Seng Ang, Millie L. Trowbridge, Chris E. Duringer, Vlad Stolojan, Sean M. Davidson, Konstantinos Savvatis, John H. McVey, Suresh Mathivanan, Aled Clayton, Patrizia Camelliti   +12 more
wiley   +1 more source

Bioinformatics of Phosphoproteomics [PDF]

, 2008
Gnad, Florian, Gnad, F.
core   +1 more source