Results 111 to 120 of about 14,144 (239)

Hypoxia‐inducible factor‐1a (HIF1a) as a context‐dependent integrator of metabolic stress in skeletal muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia‐inducible factor‐1a (HIF1a) integrates physiological and pathological inputs in skeletal muscle, including exercise, circadian timing, cytotoxins and disease. These inputs alter mitochondrial oxidative function, redox state, reactive oxygen species, and local oxygen availability, leading to intermittent or sustained HIF1a
Nicole Welch, Pugazhendhi Kannan, Seshu Vardhan Pothabathula, Annette Bellar, Abhishek A. Chakraborty, Saurabh Mishra, Srinivasan Dasarathy   +6 more
wiley   +1 more source

Transcriptomic profiling reveals conserved stage‐associated programs across gastrointestinal adenocarcinomas

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Abstract Background Gastrointestinal (GI) adenocarcinomas exhibit substantial molecular heterogeneity despite their shared epithelial origin and anatomical continuity. Whether these anatomically distinct cancers share conserved transcriptomic programs associated with pathological stage remains unclear.
Wynston Jay Abenojar, Ron Jacob Avila, Po‐Wei Tsai, Lemmuel Tayo   +3 more
wiley   +1 more source

ITCH‐Mediated Ubiquitination and Degradation of THBS1: A Key Mechanism for Enhancing Mitochondrial Biogenesis and Alleviating Mouse Skeletal Muscle Atrophy

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim Skeletal muscle atrophy is tightly associated with maladaptive alterations in mitochondrial function and morphology. Itchy E3 ubiquitin‐protein ligase (ITCH) modulates mitochondria, and thrombospondin 1 (THBS1) positively regulates muscle atrophy, but their roles in muscle atrophy are unclear. Methods A muscle atrophy model was established
Wan Yu, Yanteng Wang, Na Li, Difei Wang
wiley   +1 more source

Phosphoproteomics data from Baudouin et al. (2022).

Phosphoproteomics dataset generated by Baudouin et al. (2022).
Blein-Nicolas, Melisande
core   +1 more source

Towards single-cell LC-MS phosphoproteomics

, 2015
Protein phosphorylation is a ubiquitous posttranslational modification, which is heavily involved in signal transduction. Misregulation of protein phosphorylation is often associated with a decrease in cell viability and complex diseases such as cancer ...
Polat, Ayşe Nur; Özlü, Nurhan
core   +1 more source

CRISPR/Cas9‐Mediated Editing of Four Ca2+‐Binding Receptor‐Like Cytoplasmic Kinases Improves Soybean Seed Size and Yield at Dense Planting

Plant Biotechnology Journal, EarlyView.
Wanhong Li, Jun Jin, Tianyue Gu, Xiaoxi Cai, Bowei Jia, Yan Wang, Dezhi Han, Xiaofei Yan, Xiping Hu, Xiaoli Sun, Sijia Lu, Mingzhe Sun   +11 more
wiley   +1 more source

Inhibition of leucine‐rich kinase 2 (LRRK2) promotes peripheral axon regeneration via phosphorylation‐network remodelling

British Journal of Pharmacology, Volume 183, Issue 20, Page 6199-6224, October 2026.
Background and Purpose In contrast to neurons in the central nervous system, neurons in the peripheral nervous system can regenerate axons after injury via activation of a pro‐regenerative transcriptional programme. Pathogenic mutations in leucine‐rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, and several small ...
Eun‐Hae Jang, Eun Mo Yang, Gil Song, Seung Min Park, Harryn Choi, Jaeyong Kim, Chanil Kim, Yunho Gim, Hyuk‐Joo Jeon, Yewon Cho, Jong Bae Park, Eun‐Mi Hur   +11 more
wiley   +1 more source

Phosphoproteomics

Analytical Chemistry, 2014
Yates, John R, Mohammed, Shabaz, Heck, Albert J R   +2 more
openaire   +5 more sources

The Role of Neuropeptide Y in Dental Pulp: Balancing Neurogenic Inflammation and Pain Modulation

International Endodontic Journal, Volume 59, Issue 10, Page 2028-2045, October 2026.
ABSTRACT Background Dental pulp is a densely innervated, low‐compliance tissue in which neurogenic inflammation can rapidly escalate into oedema, raised intrapulpal pressure, microvascular compromise, and pain. While Substance P (SP) and Calcitonin gene‐related peptide (CGRP) are well‐established drivers of pulp vasodilation, the Neuroopeptide Y (NPY ...
Javier Caviedes‐Bucheli, Esteban Ulate, Hugo‐Roberto Munoz, Nestor Ríos‐Osorio   +3 more
wiley   +1 more source

Global Screening of CK2 Kinase Substrates by an Integrated Phosphoproteomics Workflow

, 2013
Due to its constitutive activity and ubiquitous distribution, CK2 is the most pleiotropic kinase among the individual members of the protein kinase superfamily.
Song, Chunxia, Qin, Hongqiang, Bian, Yangyang, Pan, Yanbo, 叶明亮, Zou, Hanfa, 邹汉法, Ye, Mingliang, Wang, Chunli, Cheng, Kai, Dong, Mingming   +10 more
core   +1 more source