Results 111 to 120 of about 12,949 (236)

Decoding MAPK cascades in plant immunity: Activation, regulation, integration, and pathogen manipulation

Journal of Integrative Plant Biology, EarlyView.
This review focuses on mitogen‐activated protein kinase (MAPK) activation and summarizes how plants regulate and integrate MAPK signaling in modulating plant immune responses. It also examines the effectors pathogens have evolved to manipulate MAPK activation and thereby inhibit plant immunity.
Guitao Zhong, Zhanchun Wang, Dingzhong Tang, Wei Wang   +3 more
wiley   +1 more source

Toward a Systems-Level View of Dynamic Phosphorylation Networks

Frontiers in Genetics, 2014
To better understand how cells sense and respond to their environment, it is important to understand the organization and regulation of the phosphorylation networks that underlie most cellular signal transduction pathways.
Robert Howard Newman, Jin eZhang, Jin eZhang, Jin eZhang, Jin eZhang, Heng eZhu, Heng eZhu   +6 more
doaj   +1 more source

Tempol Protects Against Radiation Injury in the Submandibular Gland Through the β‐Catenin Signaling Pathway

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Background Radiation damage severely impacts salivary gland function and cell survival, especially in head and neck radiotherapy. Tempol (TPL), a free radical scavenger, has shown protective effects against radiation damage. This research aimed to investigate the protective effects of TPL on radiation‐induced damage in Hs917.T cells and the ...
Jinfeng Wang, Mingjun Xu, Jinghua Zhong, Kui Zhong, Zheng Chen, Chunyu Liu, Chao Liu   +6 more
wiley   +1 more source

Designing experiments to discriminate families of logic models

Frontiers in Bioengineering and Biotechnology, 2015
Logic models of signaling pathways are a promising way of building effective in silico functional models of a cell, in particular of signaling pathways.
Santiago eVidela, Santiago eVidela, Santiago eVidela, Santiago eVidela, Irina eKonokotina, Leonidas eAlexopoulos, Julio eSaez-Rodriguez, Torsten eSchaub, Anne eSiegel, Anne eSiegel, Carito eGuziolowski   +10 more
doaj   +1 more source

Full‐Spectrum Medicinal Cannabis Plant Extract 0.08% THC (NTI164) Improves Symptoms of Rett Syndrome: An Open‐Label Study

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aim The aim of this Phase I/II open‐label study was to assess the safety and efficacy of NTI164, a novel full‐spectrum medicinal cannabis plant extract 0.08% Δ‐9‐tetrahydrocannabinol (THC), in Rett syndrome (RTT). Methods Eleven female participants (5–16 years) with a pathogenic variant in the MECP2 gene were recruited to this study, receiving
B. A. Keating, Y. Ogru, T. G. Duthy, L. Douglas, K. Lichkus, E. Isikgel, M. C. Fahey, C. Ellaway   +7 more
wiley   +1 more source

Roles of PknB and CslA in Cell Wall Morphogenesis of Streptomyces

Molecular Microbiology, EarlyView.
Streptomyces grow by extending hyphal tips, a process regulated by polarisome complexes anchored by DivIVA. Using a genetic screen based on toxic DivIVA overproduction, we identified the kinase PknB as a key regulator of cell envelope construction.
Marta Derkacz, Andrew Watson, Akshada Gajbhiye, Michał Tracz, Dagmara Jakimowicz, Matthias Trost, Jeff Errington, Bernhard Kepplinger   +7 more
wiley   +1 more source

Mycorrhiza‐induced resistance against Botrytis cinerea in tomato operates through the systemin signalling cascade

New Phytologist, EarlyView.
Prosystemin expression in mycorrhizal plants and comparative analysis of prosystemin and mycorrhiza in induced resistance. Summary Arbuscular mycorrhizal fungi enhance plant resistance against necrotrophic fungi by priming jasmonic acid‐dependent defences.
Julia Pastor‐Fernandez, María Manresa‐Grao, Paloma Sánchez‐Bel, Silvia Andrés‐Moreno, María J. Pozo, Victoria Pastor, Víctor Flors   +6 more
wiley   +1 more source

Small Extracellular Vesicle‐Associated Polymeric Immunoglobulin Receptor in Primary Liver Cancer: From Immunological Mediator to Oncogenic Driver and Biomarker

Cell Proliferation, EarlyView.
Jeremy Ting Ruei Hsu, Samuel Wan Ki Wong, Judy Yam Wai Ping   +2 more
wiley   +1 more source

Molecular Chaperone Networks in Plants: Maintaining Proteostasis and Enhancing Stress Resilience for Crop Improvement

Plant, Cell &Environment, EarlyView.
ABSTRACT Molecular chaperones play a central role in the plant proteostasis machinery by aiding the folding of nascent proteins, preventing aggregation, and repairing or degrading damaged proteins. These functions are especially essential during abiotic and biotic stress, which can destabilise cellular proteins and disrupt metabolic homoeostasis.
Mingfang Yang, Anqin Gao, Tsz‐Yan Chan, Hafiz Mamoon Rehman, Sehar Nawaz, Sehrish Bashir, Noman Mahmood, Muhammad Wajid Ullah, Chunlin Long, Hon‐Ming Lam, Muhammad Arif   +10 more
wiley   +1 more source

Isoprene‐Emitting Transgenic Tobacco Shapes Root Microbiome and Enhances Growth of Co‐Cultivated Non‐Emitting Plants

Plant, Cell &Environment, EarlyView.
ABSTRACT Isoprene is the most abundant biogenic volatile organic compound emitted by terrestrial vegetation. Here we report the impact of isoprene on root‐associated microbiomes. Using isoprene‐emitting (IE) transgenic tobacco and isogenic non‐emitting (NE) controls, we performed co‐cultivation experiments in natural soil and analysed plant phenotypes ...
Manuel Bellucci, Mohammad Golam Mostofa, Gian Maria Niccolò Benucci, Ahmad Humayan Kabir, Imran Khan, Marco Lombardi, Vittoria Locato, Gregory Bonito, Francesco Loreto, Thomas D. Sharkey   +9 more
wiley   +1 more source