Results 141 to 150 of about 27,576 (286)

SARS‐CoV‐2 nucleocapsid protein variants have differential RNA chaperone activity

The FEBS Journal, EarlyView.
The SARS‐CoV‐2 nucleocapsid (N) protein facilitates RNA annealing through its RBD–IDR2–CTD region, identifying it as a functional RNA chaperone. The Omicron BA.5 variant shows reduced chaperone activity compared to the Wuhan wild‐type protein. Although phosphorylation has no effect on wild‐type N, phosphomimetic modification of BA.5 N restores its RNA ...
Sabrina Babl, Julia M. Seidel, Fabian Kugler, Elisabeth Silberhorn, Anna Ludwig, Jonas Abel, Sophia Winklbauer, Niklas Schaub, Silvia Materna‐Reichelt, Kamran Honarnejad, Nataša Stojanović Gužvić, Gernot Längst   +11 more
wiley   +1 more source

Integrated data management and validation platform for phosphorylated tandem mass spectrometry data [PDF]

, 2010
MS/MS is a widely used method for proteome-wide analysis of protein expression and PTMs. The thousands of MS/MS spectra produced from a single experiment pose a major challenge for downstream analysis.
Carlson, Scott M., Hautaniemi, Sampsa, Lahesmaa-Korpinen, Anna-Maria, White, Forest M.   +3 more
core   +1 more source

LAT1/SLC7A5‐mediated amino acid uptake is regulated by redox signals triggered by formyl‐peptide receptor 2

The FEBS Journal, EarlyView.
FPR2 activation mediates NOX‐dependent LAT1 expression and, in turn, promotes mTORC1 signaling. Upon stimulation with WKYMVm, the FPR2‐NOX2‐ROS axis upregulates LAT1 via increased c‐Myc phosphorylation and decreased miR‐126. Additionally, it promotes CD98 translocation to the plasma membrane.
Myrhiam Cassese, Chiara Brignola, Stefano Marrone, Gabriella Esposito, Rosario Ammendola, Fabio Cattaneo   +5 more
wiley   +1 more source

PiTRAQ, a strategy to simultaneously correlate protein expression and phosphorylation stoichiometry between different samples: evaluation on different mass spectrometers [PDF]

, 2013
C
Colaert, Niklaas, Deforce, Dieter, Dhaenens, Maarten, Glibert, Pieter, Martens, Lennart, Meert, Paulien, Van Nieuwerburgh, Filip   +6 more
core   +1 more source

Proteome Profiling of Wheat Shoots from Different Cultivars [PDF]

, 2017
Wheat is a cereal grain and one of the world's major food crops. Recent advances in wheat genome sequencing are by now facilitating its genomic and proteomic analyses.
Elisabeth Stes, Frederik Coppens, Inge Verstraeten, Ive De Smet, Kris Gevaert, Lam Dai Vu, Michiel Van Bel   +6 more
core   +1 more source

A Hanks‐type bacterial kinase, PknS, directly phosphorylates the alternative sigma factor EcfK to promote resistance to protist predation

The FEBS Journal, EarlyView.
The Xanthomonas citri Hanks‐type kinase PknS autophosphorylates and directly phosphorylates the alternative sigma factor EcfK at five residues. Besides the conserved residue T51 in the σ2 domain, phosphorylation of a residue in the linker between σ2 and σ4 is critical for EcfK activation by promoting its interaction with a positively charged pocket in ...
Lídia dos Passos Lima, Dev Sriranganadane, Daiane Laise da Silva, Natália C. Drebes Dörr, Enzo Breviglieri Sichi Mello, Caio Vinicius dos Reis, Rogério Ferreira Lourenço, José Felipe Teixeira da Silva Santos, Anita Salmazo, Brenno Wendler Miranda, Katlin B. Massirer, Rafael M. Couñago, Cristina E. Alvarez‐Martinez   +12 more
wiley   +1 more source

Plasmodium falciparum ligand binding to erythrocytes induce alterations in deformability essential for invasion [PDF]

, 2017
The most lethal form of malaria in humans is caused by Plasmodium falciparum. These parasites invade erythrocytes, a complex process involving multiple ligand-receptor interactions.
Cowman, Alan, Fleig, Andrea, Horgen, F. David, Malpede, Brian M, Nebl, Thomas, O\u27Neill, Joseph, Rogers, Kelly, Salinas, Nichole D, Sisquella, Xavier, Tham, Wai-Hong, Thompson, Jennifer K, Tolia, Niraj H, Whitehead, Lachlan   +12 more
core   +2 more sources

Strong anion exchange‐mediated phosphoproteomics reveals extensive human non‐canonical phosphorylation

EMBO Journal, 2019
Phosphorylation is a key regulator of protein function under (patho)physiological conditions, and defining site‐specific phosphorylation is essential to understand basic and disease biology.
Gemma E. Hardman, S. Perkins, Philip J. Brownridge, C. Clarke, D. Byrne, Amy E. Campbell, A. Kalyuzhnyy, A. Myall, P. Eyers, Andrew R. Jones, C. Eyers   +10 more
semanticscholar   +1 more source

Hybrid sorghum breeding in China: A historical review and perspectives

Journal of Integrative Plant Biology, EarlyView.
To commemorate the 60th anniversary of the promotion and application of three‐line hybrid sorghum in China, this review highlights pivotal scientific breakthroughs, systematically summarizes the progress in hybrid sorghum breeding and dwarf sorghum breeding in the country, and presents an outlook on the future of sorghum breeding.
Xiangxiang Meng, Lu Li, Qian Qian, Liang Jiang, Zhaosheng Kong   +4 more
wiley   +1 more source

A global view of substrate phosphorylation and dephosphorylation during budding yeast mitotic exit

Microbial Cell, 2018
The cell cycle is the process by which a cell duplicates its DNA during S-phase and divides its chromosomes during M-phase, creating two genetically identical daughter cells.
Sandra A. Touati, Frank Uhlmann
doaj   +1 more source