Results 161 to 170 of about 27,576 (286)
A Network‐Based Approach to Understanding Key Signaling Pathways in Intervertebral Disc Biology
A literature‐based signaling network capturing the most relevant pathways in human nucleus pulposus cells was first constructed from curated biological evidence. The network was then translated into a system of ordinary differential equations to derive steady‐state solutions and define median baseline activity levels.
Sofia Tseranidou +11 more
wiley +1 more source
Abstract Wheat (Triticum aestivum L.), a foundation of global food security, faces persistent threats from stripe rust caused by Puccinia striiformis f. sp. tritici (Pst). The pathogen thrives in cool and humid environments and regularly causes epidemics that lead to severe yield losses.
Farkhandah Jan +11 more
wiley +1 more source
Phosphoproteomic Techniques and Applications
Phosphoproteomic analysis seeks to determine the overall level of protein phosphorylation, as a result of kinase and phosphatase activity, and determine the identity of proteins which are phosphorylated and the amino acid residues which hold the phosphate group.
Ed, Dudley, A Elizabeth, Bond
openaire +4 more sources
• XPO1 hyperactivation promotes leukaemogenesis by altering nucleocytoplasmic transport and transcriptional control in acute myeloid leukaemia (AML). • Selinexor and eltanexor show preferential activity in NPM1‐mutated, DEK::NUP214‐positive and SF3B1‐mutated myeloid neoplasms.
Yifan Liu +4 more
wiley +1 more source
Focus on Phosphoproteomics [PDF]
Carol, Nilsson +2 more
openaire +2 more sources
Fully Tunable Phosphorylation of RPS6A Ensures the Successful Development of Arabidopsis Seedlings
ABSTRACT Light enhances protein translation, enabling young seedlings to rapidly and timely acquire photosynthetic capacities. Sequential phosphorylation of ribosomal protein S6 (RPS6) was implicated in the light‐enhanced translation; however, the exact phosphorylation sites and the biological relevance of RPS6 multi‐phosphorylation in seedling ...
Yueh Cho +2 more
wiley +1 more source
PhosphoPep—a phosphoproteome resource for systems biology research in Drosophila Kc167 cells
The ability to analyze and understand the mechanisms by which cells process information is a key question of systems biology research. Such mechanisms critically depend on reversible phosphorylation of cellular proteins, a process that is catalyzed by ...
Bernd Bodenmiller +13 more
doaj +1 more source
A multi-purpose, regenerable, proteome-scale, human phosphoserine resource for phosphoproteomics
Brandon M. Gassaway +11 more
semanticscholar +1 more source
Parallel phosphoproteomics and metabolomics map the global metabolic tyrosine phosphoproteome
AbstractTyrosine phosphorylation of metabolic enzymes is an evolutionarily conserved post-translational modification that facilitates rapid and reversible modulation of enzyme activity, localization or function. Despite the high abundance of tyrosine phosphorylation events detected on metabolic enzymes in high-throughput mass spectrometry-based studies,
Alissandra L. Hillis +8 more
openaire +2 more sources

