Results 151 to 160 of about 14,675 (189)
Some of the next articles are maybe not open access.
2015
Cereals are the most important crop plant supplying staple food throughout the world. The economic importance and continued breeding of crop plants such as rice, maize, wheat, or barley require a detailed scientific understanding of adaptive and developmental processes.
openaire +2 more sources
Cereals are the most important crop plant supplying staple food throughout the world. The economic importance and continued breeding of crop plants such as rice, maize, wheat, or barley require a detailed scientific understanding of adaptive and developmental processes.
openaire +2 more sources
Illuminating the dark phosphoproteome
Science Signaling, 2019Identifying the targets of “dark” kinases will provide new biological and disease insights.
Elise J. Needham +4 more
openaire +2 more sources
Phosphoproteomics takes it easy
Nature Biotechnology, 2015The EasyPhos pipeline simplifies analysis of phosphorylation-dependent signaling networks at high temporal resolution.
openaire +3 more sources
Phosphoproteomics and cancer research
Clinical and Translational Oncology, 2009Protein phosphorylation plays key roles in the regulation of normal and cancer cells. It is a highly dynamic process. Protein kinases are the targets of several new cancer drugs and drug candidates. However, some of the main issues related to new drugs are how they function and the selection of those patients that will likely respond best to a ...
Ashman, Keith, Lopez Villar, Elena
openaire +5 more sources
Analytical strategies for phosphoproteomics
PROTEOMICS, 2009AbstractProtein phosphorylation is a key regulator of cellular signaling pathways. It is involved in most cellular events in which the complex interplay between protein kinases and protein phosphatases strictly controls biological processes such as proliferation, differentiation, and apoptosis.
Thingholm, Tine E +2 more
openaire +2 more sources
Phosphoproteomics in drug discovery
Drug Discovery Today, 2014Several important aspects of the drug discovery process, including target identification, mechanism of action determination and biomarker identification as well as drug repositioning, require complete understanding of the effects of drugs on protein phosphorylation in relevant biological systems.
Melody K. Morris +3 more
openaire +2 more sources
2011
The identification of phosphorylation on proteins has become practicable for many laboratories in recent years, largely due to improvements in mass spectrometry (MS) and the development of methods to selectively enrich for phosphorylated peptides and proteins.
Alexandra M E, Jones, Thomas S, Nühse
openaire +2 more sources
The identification of phosphorylation on proteins has become practicable for many laboratories in recent years, largely due to improvements in mass spectrometry (MS) and the development of methods to selectively enrich for phosphorylated peptides and proteins.
Alexandra M E, Jones, Thomas S, Nühse
openaire +2 more sources
Phosphoproteomics in photosynthetic organisms
ELECTROPHORESIS, 2014As primarily sessile organisms, photosynthetic species survive in dynamic environments by using elegant signaling pathways to manifest molecular responses to extracellular cues. These pathways exploit phosphorylation of specific amino acids (e.g. serine, threonine, tyrosine), which impact protein structure, function, and localization.
William O, Slade +3 more
openaire +2 more sources
Plant Phosphoproteomics: A Long Road Ahead
Proteomics, 2006 Phosphoproteomics can be defined as the comprehensive study of protein phosphorylation by identification of the phosphoproteins, exact mapping of the phosphorylation sites, quantification of phosphorylation, and eventually, revealing their biological ...
Birgit Kersten +2 more
exaly +1 more source
Towards the Phosphoproteome of Trypanosomatids
2013The identification and localization of protein phosphorylation sites provide clues to what proteins or pathways might be activated in a given condition, helping to improve our understanding about signaling networks. Advances in strategies for enrichment of phosphorylated peptides/proteins, mass spectrometry (MS) instrumentation, and specific MS ...
Fabricio K, Marchini +4 more
openaire +2 more sources