Results 161 to 170 of about 407,505 (399)

Unraveling Plant Recombination Patterns: Insights From Genome k‐mers

Plant Direct
Crossover recombination is a pivotal event that takes place during meiosis of germinal cells, leading to the rearrangement of parental chromosomes and generating novel allele combinations, thereby enhancing genetic diversity.
Mauricio Peñuela, Camila Riccio‐Rengifo, Jorge Finke, Camilo Rocha   +3 more
doaj   +1 more source

Graph machine learning for integrated multi-omics analysis

British Journal of Cancer
Multi-omics experiments at bulk or single-cell resolution facilitate the discovery of hypothesis-generating biomarkers for predicting response to therapy, as well as aid in uncovering mechanistic insights into cellular and microenvironmental processes ...
N. Valous, Ferdinand Popp, I. Zörnig, D. Jäger, P. Charoentong   +4 more
semanticscholar   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR‐Dependent Translational Control of Synaptic Proteins

Advanced Science, EarlyView.
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren, Renhe Cao, Xiaoshan Ye, Wenbin Pang, Qingshang Bi, Meihui Huang, Qionglin Zhou, Dan Ye, Wei Xiang, Le Xiao   +9 more
wiley   +1 more source

The Space Omics and Medical Atlas (SOMA) and international astronaut biobank

Nature
Spaceflight induces molecular, cellular and physiological shifts in astronauts and poses myriad biomedical challenges to the human body, which are becoming increasingly relevant as more humans venture into space1–6.
Eliah G. Overbey, Jangkeun Kim, B. Tierney, Jiwoon Park, Nadia Houerbi, Alexander G Lucaci, Sebastian Garcia Medina, N. Damle, D. Najjar, K. Grigorev, Evan E. Afshin, K. Ryon, K. Sienkiewicz, L. Patras, Remi Klotz, Veronica Ortiz, M. Mackay, A. Schweickart, Christopher R. Chin, Maria A. Sierra, Matias F Valenzuela, E. Dantas, Theodore M. Nelson, Egle Cekanaviciute, Gabriel Deards, J. Foox, S. A. Narayanan, Caleb M. Schmidt, Michael A. Schmidt, Julian C. Schmidt, Sean Mullane, S. S. Tigchelaar, Steven Levitte, Craig D. Westover, Chandrima Bhattacharya, Serena Lucotti, J. Wain Hirschberg, J. Proszynski, Marissa Burke, Ashley S. Kleinman, D. Butler, C. Loy, Omary Mzava, J. Lenz, Doru Paul, C. Mozsary, Lauren M. Sanders, Lynn Taylor, Chintan O. Patel, Sharib A. Khan, Mir Suhail Mohamad, S. G. Byhaqui, Burhan Aslam, Aaron S Gajadhar, Lucy Williamson, Purvi Tandel, Qiu Yang, Jessica Chu, Ryan W Benz, Asim Siddiqui, Daniel Hornburg, Kelly Blease, Juan Moreno, Andrew M. Boddicker, Junhua Zhao, Bryan R. Lajoie, Ryan T. Scott, R. Gilbert, San-huei Lai Polo, Andrew Altomare, S. Kruglyak, Shawn Levy, Ishara S. Ariyapala, Joanne C. Beer, Bingqing Zhang, Briana M. Hudson, Aric Rininger, Sarah E. Church, Afshin Beheshti, George M. Church, Scott M. Smith, Brian E. Crucian, S. Zwart, Irina R Matei, D. Lyden, Francine E. Garrett-Bakelman, J. Krumsiek, Qiuying Chen, Dawson Miller, Joe Shuga, Stephen R. Williams, Corey M. Nemec, Guy Trudel, M. Pelchat, O. Laneuville, Iwijn De Vlaminck, Steven S. Gross, Kelly L. Bolton, Susan M Bailey, Richard D. Granstein, D. Furman, Ari M. Melnick, S. Costes, B. Shirah, Min Yu, Anil S. Menon, Jaime Mateus, Cem Meydan, Christopher E. Mason   +108 more
semanticscholar   +1 more source

A Unique Chimeric RNA: ERCC1‐iASPP Drives Benzo[a]pyrene‐Induced Lung Carcinogenesis via Dual Coding and Non‐Coding Mechanisms

Advanced Science, EarlyView.
The chimeric RNA ERCC1‐iASPP possesses dual coding and non‐coding functions, synergistically accelerating the process of cellular malignant transformation. Abstract Genetic variation at 19q13.3 critically modulates chemical carcinogen‐induced lung carcinogenesis, particularly in mediating the activity of benzo[a]pyrene (B[a]P), a major polycyclic ...
Mingming Shan, Mingyang Xiao, Liang Zhang, Shen Wang, Jiahang Wu, Kang Cao, Yujin Li, Guopei Zhang, Junwei Xie, Xiaobo Lu   +9 more
wiley   +1 more source

Berberine Mediates Exosomes Regulating the Lipid Metabolism Pathways to Promote Apoptosis of RA-FLS Cells

Pharmaceuticals
Objectives: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint damage and commonly linked to symptoms such as inflammation, swelling, and pain.
Si-Fan Guo, Zhi-Bo Wang, Dan-Dan Xie, Ying Cai, Yan Wang, Xian Wang, Qiang Yang, Ai-Hua Zhang, Shi Qiu   +8 more
doaj   +1 more source

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

Gut microbiome encoded purine and amino acid pathways present prospective biomarkers for predicting metformin therapy efficacy in newly diagnosed T2D patients

Gut Microbes
Metformin is widely used for treating type 2 diabetes mellitus (T2D). However, the efficacy of metformin monotherapy is highly variable within the human population.
Ilze Elbere, Zigmunds Orlovskis, Laura Ansone, Ivars Silamikelis, Lauma Jagare, Liga Birzniece, Kaspars Megnis, Kristaps Leskovskis, Annija Vaska, Maris Turks, Kristaps Klavins, Valdis Pirags, Monta Briviba, Janis Klovins   +13 more
doaj   +1 more source

Identifying potential therapeutic targets in lung adenocarcinoma: a multi-omics approach integrating bulk and single-cell RNA sequencing with Mendelian randomization [PDF]

Youpeng Chen, Enzhong Li, Zhenglin Chang, Tingting Zhang, Zhenfeng Song, Haojie Wu, Zhangkai J. Cheng, Baoqing Sun   +7 more
openalex   +1 more source